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RNF213 [cytosol]
Stable Identifier
R-HSA-9635613
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="34"E3 ubiquitin-protein ligase RNF213 ecNumber evidence="16"2.3.2.27/ecNumber ecNumber evidence="16"3.6.4.-/ecNumber, RN213_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of apoptosis (Homo sapiens)
Rv3655c binds RNF213 (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Rv3655c:RFN213 [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q63HN8 RNF213
Gene Names
RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR
Chain
chain:1-5207
Reference Genes
COSMIC (genes):RNF213 RNF213
dbSNP Gene:57674 RNF213
ENSEMBL:ENSG00000173821 RNF213
Participates
as a component of
Rv3655c:RFN213 [cytosol] (Homo sapiens)
as an input of
Rv3655c binds RNF213 (Homo sapiens)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
Inferred To
Rnf213 [cytosol]
(Rattus norvegicus)
LOC100496402 [cytosol]
(Xenopus tropicalis)
Homologues of RNF213 [cytosol]
(Dictyostelium discoideum)
RNF213 [cytosol]
(Bos taurus)
RNF213 [cytosol]
(Canis familiaris)
RNF213 [cytosol]
(Danio rerio)
RNF213 [cytosol]
(Dictyostelium discoideum)
RNF213 [cytosol]
(Gallus gallus)
RNF213 [cytosol]
(Mus musculus)
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10321 HLA-C
8
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236760)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863915)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]
(R-HSA-1236799)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983354)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]
(R-HSA-983387)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane]
(R-HSA-199595)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane]
(R-HSA-6803292)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983044)
0.564
2
UniProt:Q8N7X8 SIGL1
0.527
2
UniProt:Q9UQV4 LAMP3
0.527
2
UniProt:O60939 SCN2B
1
SCN2B [plasma membrane]
(R-HSA-197905)
0.527
2
UniProt:P18031 PTPN1
2
PTPN1 [endosome membrane]
(R-HSA-9815895)
PTPN1 [cytosol]
(R-HSA-210625)
0.527
2
UniProt:P34741 SDC2
20
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
HS(3)-SDC2 [plasma membrane]
(R-HSA-2076631)
HS(5)-SDC2 [plasma membrane]
(R-HSA-2076665)
SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956741)
p-SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956945)
XylS-SDC2 [Golgi lumen]
(R-HSA-2064109)
Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2064132)
SDC2 [Golgi lumen]
(R-HSA-2054101)
Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063988)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
0.527
2
UniProt:Q14978 NOLC1
0.483
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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