Reactome | RNF213 [cytosol]

RNF213 [cytosol]

Stable Identifier

R-HSA-9635613

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="34"E3 ubiquitin-protein ligase RNF213 ecNumber evidence="16"2.3.2.27/ecNumber ecNumber evidence="16"3.6.4.-/ecNumber, RN213_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q86WC4 OSTM1

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of apoptosis (Homo sapiens)
        
        Rv3655c binds RNF213 (Homo sapiens)
        
        RNF213 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q63HN8 RNF213

Gene Names

RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR

Chain

chain:1-5207

Reference Genes

BioGPS Gene:57674 RNF213

COSMIC (genes):RNF213 RNF213

CTD Gene:57674 RNF213

dbSNP Gene:57674 RNF213

ENSEMBL:ENSG00000173821 RNF213

HGNC:14539 RNF213

KEGG:hsa:57674 RNF213

Monarch:57674 RNF213

NCBI Gene:57674 RNF213

OMIM:613768 RNF213

UCSC:Q63HN8 RNF213

Reference Transcript

Participates

as a component of

Rv3655c:RFN213 [cytosol] (Homo sapiens)

as an input of

Rv3655c binds RNF213 (Homo sapiens)

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Other forms of this molecule

RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]

RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]

Inferred To

Rnf213 [cytosol] (Mus musculus)

Rnf213 [cytosol] (Rattus norvegicus)

LOC100496402 [cytosol] (Xenopus tropicalis)

Homologues of RNF213 [cytosol] (Dictyostelium discoideum)

rnf213a [cytosol] (Danio rerio)

LOC509283 [cytosol] (Bos taurus)

RNF213 [cytosol] (Canis familiaris)

RNF213 [cytosol] (Dictyostelium discoideum)

RNF213 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001243000.2, NP_066005.2

ENSEMBL

ENSG00000173821, ENST00000319921, ENSP00000324392

OpenTargets

ENSG00000173821

IntEnz

2.3.2.27

GeneCards

RNF213

HPA

ENSG00000173821-RNF213

PRO

Q63HN8

Pharos - Targets

Q63HN8

GlyGen

Q63HN8

Orphanet

RNF213

PDB

8S24

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60939 SCN2B	1	SCN2B [plasma membrane] (R-HSA-197905)	0.643	3
UniProt:P10321 HLA-C	8	HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983044) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (R-HSA-199595) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane] (R-HSA-6803292) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane] (R-HSA-983387) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983354) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (R-HSA-1236799) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane] (R-HSA-8863915) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236760)	0.564	2
UniProt:Q86WC4 OSTM1	1	OSTM1 [lysosomal membrane] (R-HSA-2730944)	0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.527	2
UniProt:O00526 UPK2			0.527	3
UniProt:Q7LGA3 HS2ST1	1	HS2ST1 [Golgi membrane] (R-HSA-2076393)	0.527	2
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.527	2
UniProt:P21462 FPR1	4	FPR1 [plasma membrane] (R-HSA-375450) FPR1 [ficolin-1-rich granule membrane] (R-HSA-6800878) FPR1 [secretory granule membrane] (R-HSA-6800929) FPR1 [azurophil granule membrane] (R-HSA-6799143)	0.527	2
UniProt:Q9NQ34 TMM9B			0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q9Y279 VSIG4			0.527	2
UniProt:Q9UQV4 LAMP3			0.527	2
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.527	2
UniProt:Q13304 GPR17	1	GPR17 [plasma membrane] (R-HSA-416429)	0.527	2
UniProt:Q14978 NOLC1			0.483	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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