Reactome | PTPN7 [cytosol]

PTPN7 [cytosol]

Stable Identifier

R-HSA-9635737

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 7, HEPTP, Hematopoietic protein-tyrosine phosphatase

Locations in the PathwayBrowser for interactor UniProt:P28482 MAPK1

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        PTPN7 binds p-T,Y-MAPK (Homo sapiens)
        
        PTPN7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35236 PTPN7

Gene Names

PTPN7

Chain

chain:1-360

Reference Genes

BioGPS Gene:5778 PTPN7

COSMIC (genes):PTPN7 PTPN7

CTD Gene:5778 PTPN7

dbSNP Gene:5778 PTPN7

ENSEMBL:ENSG00000143851 PTPN7

HGNC:9659 PTPN7

KEGG Gene (Homo sapiens):5778 PTPN7

Monarch:5778 PTPN7

NCBI Gene:5778 PTPN7

OMIM:176889 PTPN7

UCSC:P35236 PTPN7

Reference Transcript

Other Identifiers

0003190133

0004780020

11732169_a_at

11748520_a_at

11748867_a_at

11749268_a_at

11749269_x_at

11750505_a_at

11750506_x_at

11760014_x_at

16697995

1760_s_at

204852_s_at

2451156

2451157

2451158

2451159

2451160

2451161

2451162

2451163

2451166

2451167

2451169

2451171

2451173

2451175

2451176

2451177

2451180

2451181

2451182

2451183

2451184

2451185

39672_at

5778

7923406

A_23_P201778

A_24_P276808

D11327_s_at

GE81200

GO:0003674

GO:0004721

GO:0004725

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006464

GO:0006470

GO:0008150

GO:0009898

GO:0016311

GO:0016787

GO:0016791

GO:0035335

GO:0043226

GO:0071345

ILMN_1715214

ILMN_1749998

ILMN_2257223

PH_hs_0024615

TC01003700.hg

TC01006042.hg

g4506298_3p_a_at

Participant Of

input

PTPN7 binds p-T,Y-MAPK

hasComponent

Other forms of this molecule

PTPN7 [nucleoplasm]

Inferred To

PTPN7 [cytosol] (Bos taurus)

PTPN7 [cytosol] (Canis familiaris)

ptpA1-2 [cytosol] (Dictyostelium discoideum)

ptpn5 [cytosol] (Danio rerio)

Ptpn7 [cytosol] (Mus musculus)

Ptpn7 [cytosol] (Rattus norvegicus)

Homologues of PTPN7 [cytosol] (Dictyostelium discoideum)

PTP-ER [cytosol] (Drosophila melanogaster)

ptpB [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002823.3, NP_542155.1

OpenTargets

ENSG00000143851

GeneCards

P35236

HPA

ENSG00000143851-PTPN7

ZINC - Substances

PTN7_HUMAN

ZINC target

P35236

Ensembl

ENST00000495688, ENSP00000356248, ENSP00000420506, ENSP00000309116, ENST00000309017, ENSG00000143851, ENST00000367279

PRO

P35236

ZINC - Predictions - Purchasable

PTN7_HUMAN

HMDB Protein

HMDBP08161

PDB

1ZC0, 2A3K, 3O4U, 2QDM, 3D44, 2QDC, 3D42, 2HVL, 2GPH, 3O4T, 2GP0, 3O4S, 2QDP

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.775	6
UniProt:P47811 Mapk14	7	Mapk14 [extracellular region] (R-MMU-6806453) Mapk14 [ficolin-1-rich granule lumen] (R-MMU-6803280) Mapk14 [secretory granule lumen] (R-MMU-6803300) Mapk14 [nucleoplasm] (R-MMU-446223) MAP kinase p38 alpha [cytosol] (R-MMU-448843) phospho-MAP kinase p38 alpha [cytosol] (R-MMU-448842) p-T180,Y182-Mapk14 [nucleoplasm] (R-MMU-1605486)	0.589	2
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3

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