NEIL3 resolves abasic site-induced ICLs

Stable Identifier
R-HSA-9636008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL3 resolves abasic site-induced ICLs
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Based on studies in Xenopus, NEIL3 is able to resolve abasic site-induced interstrand crosslinks (AP-ICLs), that form when an aldehyde group of the AP site reacts with the amine of a nucleic acid base, usually adenine, on the opposite strand. NEIL3-mediated unhooking of AP-ICLs is independent of the Fanconi anemia (FA) pathway (Semlow et al. 2016).
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Catalyst Activity

DNA N-glycosylase activity of NEIL3 [nucleoplasm]

Physical Entity
NEIL3 [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Inferred From
neil3 resolves AP-ICLs (Xenopus laevis)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Zhou, J  (2019-02-11)
Created
Orlic-Milacic, M  (2019-02-12)
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