Reactome | TLR2 [plasma membrane]

TLR2 [plasma membrane]

Stable Identifier

R-HSA-9637646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Toll-like receptor 2, TLR2_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60603 TLR2

Gene Names

TLR2, TIL4

Chain

signal peptide:1-20, chain:21-784

Reference Genes

BioGPS Gene:7097 TLR2

COSMIC (genes):TLR2 TLR2

CTD Gene:7097 TLR2

dbSNP Gene:7097 TLR2

ENSEMBL:ENSG00000137462 TLR2

ENSEMBL_homo_sapiens_GENE:ENSG00000137462.9 TLR2

HGNC:11848 TLR2

KEGG Gene (Homo sapiens):7097 TLR2

Monarch:7097 TLR2

NCBI Gene:7097 TLR2

OMIM:603028 TLR2

UCSC:O60603 TLR2

Reference Transcript

Other Identifiers

11736273_a_at

11736274_at

11754833_a_at

16971631

204924_PM_at

204924_at

2748348

2748352

2748353

2748355

2748356

2748357

2748358

2748372

2748374

2748375

2748376

2748377

2748379

2748389

40310_at

67317_r_at

7097

8097903

A_14_P200129

A_23_P92499

GE54434

GE835871

GO:0001530

GO:0001540

GO:0001666

GO:0001774

GO:0001875

GO:0002224

GO:0002376

GO:0003824

GO:0004888

GO:0005515

GO:0005737

GO:0005794

GO:0005886

GO:0006351

GO:0006355

GO:0006691

GO:0006915

GO:0006954

GO:0006955

GO:0007165

GO:0007252

GO:0007612

GO:0008285

GO:0008289

GO:0009636

GO:0009986

GO:0010628

GO:0012501

GO:0014005

GO:0016020

GO:0016192

GO:0016787

GO:0023052

GO:0030154

GO:0030177

GO:0030667

GO:0030670

GO:0031410

GO:0031663

GO:0032289

GO:0032493

GO:0032496

GO:0032570

GO:0032722

GO:0032728

GO:0032733

GO:0032735

GO:0032741

GO:0032755

GO:0032757

GO:0032760

GO:0032868

GO:0034134

GO:0034330

GO:0035325

GO:0035354

GO:0035355

GO:0036211

GO:0038023

GO:0038124

GO:0038187

GO:0042495

GO:0042496

GO:0042497

GO:0042802

GO:0042834

GO:0042995

GO:0043226

GO:0043235

GO:0044297

GO:0044877

GO:0045087

GO:0045121

GO:0045944

GO:0046209

GO:0048714

GO:0048856

GO:0050135

GO:0050729

GO:0050765

GO:0050830

GO:0050877

GO:0051092

GO:0051607

GO:0051770

GO:0051964

GO:0060089

GO:0061809

GO:0070542

GO:0071221

GO:0071223

GO:0071346

GO:0071723

GO:0071726

GO:0071727

GO:0098542

GO:1901224

GO:1903974

GO:1904466

HMNXSV003000262

ILMN_1772387

PH_hs_0030266

TC04000775.hg

TC04002279.hg

g4507528_3p_at

p26819

p33883

Participates

as a component of

as an input of

Other forms of this molecule

TLR2 [secretory granule membrane]

TLR2 [plasma membrane]

Cross References

RefSeq

XP_016864062.1, NP_001305719.1, XP_011530518.1, NP_001305718.1, NP_001305724.1, XP_016864063.1, NP_001305716.1, NP_001305725.1, XP_016864064.1, NP_003255.2, NP_001305720.1, XP_011530517.1, NP_001305722.1, XP_016864065.1

ZINC - World Drugs

TLR2_HUMAN

Guide to Pharmacology - Targets

1752

OpenTargets

ENSG00000137462

ZINC - Substances

TLR2_HUMAN

ZINC - Biogenic

TLR2_HUMAN

ZINC target

O60603

PRO

O60603

PDB

6NIG, 1FYW, 1FYX, 2Z7X, 2Z80, 8AR0, 1O77

ZINC - Metabolites

TLR2_HUMAN

HPA

ENSG00000137462-TLR2

GeneCards

O60603

Ensembl

ENST00000642700, ENSP00000494425, ENST00000642580, ENSP00000495339, ENSP00000260010, ENST00000260010, ENSG00000137462

Pharos - Targets

O60603

ZINC - Predictions - Purchasable

TLR2_HUMAN

HMDB Protein

HMDBP12412

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.737	4
UniProt:Q9Y2C9 TLR6	1	TLR6 [plasma membrane] (R-HSA-168061)	0.681	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.681	3
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.59	3
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-167992)	0.581	4
UniProt:Q96DA0 PAUF			0.576	3
UniProt:Q9BXR5 TLR10	1	TLR10 [plasma membrane] (R-HSA-167926)	0.573	3
UniProt:P36894 BMPR1A	2	BMPR1A [plasma membrane] (R-HSA-201480) p-4S-BMPR1A [plasma membrane] (R-HSA-201448)	0.527	2
UniProt:P42229 STAT5A	4	STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.527	2
UniProt:Q6NUQ4 TM214			0.527	2
UniProt:Q15399 TLR1	1	TLR1 [plasma membrane] (R-HSA-6787702)	0.508	3

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