esxA translocates from Mtb cytosol to the host's ER

Stable Identifier
R-HSA-9637651
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol, endoplasmic reticulum lumen
ReviewStatus
5/5
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esxA translocates from Mtb cytosol to the host's ER
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Mtb secreted 6 kDa early secretory antigenic target (esxA) succeeds in entering the endoplasmic reticulum of host macrophages by an unknown mechanism (Sreejit et al. 2014).
Literature References
PubMed ID Title Journal Year
25356553 The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage

Sreejit, G, Parveen, N, Ghosh, S, Mukhopadhyay, S, Jha, V, Valluri, VL, Ahmed, A

PLoS Pathog. 2014
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-19)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-19)
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