CpnT hydrolyses NAD+

Stable Identifier
R-HSA-9637699
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
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The C-terminal domain of CpnT, tuberculosis necrotizing toxin (TNT) has NAD+ hydrolase activity. Its secretion depletes NAD+ in the cytosol of the phagocyte which leads to necrosis (Sun et al. 2015).

Literature References
PubMed ID Title Journal Year
26237511 The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

Sun, J, Siroy, A, Lokareddy, RK, Speer, A, Doornbos, KS, Cingolani, G, Niederweis, M

Nat. Struct. Mol. Biol. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD glycohydrolase activity of cpnT [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Rhea
Authored
Reviewed
Created
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