ACY3:Zn2+ dimer hydrolyses mercapturic acids

Stable Identifier
R-HSA-9638046
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic aminocyclases 1 and 3 (ACY1,3) can hydrolyse N-acylated amino acids and N-acylcysteine-S-conjugates (Lindner et al. 2003). They are functional as dimers and utilise zinc as a cofactor.

Literature References
PubMed ID Title Journal Year
12933810 Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family

Lindner, HA, Lunin, VV, Alary, A, Hecker, R, Cygler, M, Ménard, R

J. Biol. Chem. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aminoacylase activity of ACY3:Zn2+ dimer [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created