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SESN1 [cytosol]
Stable Identifier
R-HSA-9638235
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="14"Sestrin-1 ecNumber evidence="3"1.11.1.15/ecNumber, SESN1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)
MAP1LC3B:SESN1,2:ub K420 p-S349 SQSTM1 oligomer:ub-KEAP1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
SESN1,2:L-Leu [cytosol] (Homo sapiens)
SESN1,2 [cytosol] (Homo sapiens)
SESN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6P5 SESN1
Gene Names
SESN1, PA26, SEST1
Chain
chain:1-492
Reference Genes
BioGPS Gene:27244 SESN1
COSMIC (genes):SESN1 SESN1
CTD Gene:27244 SESN1
dbSNP Gene:27244 SESN1
ENSEMBL:ENSG00000080546 SESN1
ENSEMBL_homo_sapiens_GENE:ENSG00000080546.14 SESN1
HGNC:21595 SESN1
KEGG Gene (Homo sapiens):27244 SESN1
Monarch:27244 SESN1
NCBI Gene:27244 SESN1
OMIM:606103 SESN1
UCSC:Q9Y6P5 SESN1
Reference Transcript
RefSeq:NM_001199933.1 SESN1
RefSeq:NM_014454.2 SESN1
RefSeq:NM_001199934.1 SESN1
Other Identifiers
11719062_a_at
11719063_a_at
17022362
218346_PM_s_at
218346_s_at
27244
2968653
2968654
2968655
2968656
2968659
2968660
2968662
2968665
2968668
2968669
2968670
2968671
2968672
2968674
2968675
2968677
2968678
2968694
2968695
2968704
2968706
2968708
73404_at
8128698
91425_at
A_23_P93562
A_24_P346339
GE54252
GO:0001650
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006914
GO:0016239
GO:0016491
GO:0016684
GO:0023052
GO:0034198
GO:0042149
GO:0043226
GO:0051716
GO:0061700
GO:0070728
GO:0071233
GO:0072593
GO:0098754
GO:0098869
GO:1901031
GO:1904262
GO:1990253
HMNXSV003040222
HMNXSV003052493
PH_hs_0001349
TC06001997.hg
g7657436_3p_a_at
Participates
as a member of
SESN1,2 [cytosol] (Homo sapiens)
Inferred To
SESN1 [cytosol]
(Bos taurus)
SESN1 [cytosol]
(Canis familiaris)
SESN1 [cytosol]
(Sus scrofa)
sesn-1 [cytosol]
(Caenorhabditis elegans)
sesn1 [cytosol]
(Xenopus tropicalis)
SESN1-1 [cytosol]
(Dictyostelium discoideum)
SESN1-1 [cytosol]
(Gallus gallus)
SESN1-1 [cytosol]
(Mus musculus)
Sesn1 [cytosol]
(Rattus norvegicus)
Sesn [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001186863.1
,
NP_055269.1
,
NP_001186862.1
OpenTargets
ENSG00000080546
HPA
ENSG00000080546-SESN1
GeneCards
Q9Y6P5
Ensembl
ENSG00000080546
,
ENSP00000393762
,
ENSP00000306734
,
ENST00000356644
,
ENSP00000349061
,
ENST00000302071
,
ENST00000436639
PRO
Q9Y6P5
Pharos - Targets
Q9Y6P5
Orphanet
24893
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