RRAGC,D exchanges GTP for GDP

Stable Identifier
R-HSA-9639286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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The Ragulator complex acts as an unconventional guanyl nucleotide exchange factor (GEF) that ejects GTP from RRAGC and, by inference, RRAGD (Shen and Sabatini 2018). (Other known GEFs cause ejection of GDP rather than GTP from their targets.) The GDP-bound form of RRAGC,D is the active form that recruits mTORC1 to the lysosomal membrane.

Literature References
PubMed ID Title Journal Year
30181260 Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Shen, K, Sabatini, DM

Proc. Natl. Acad. Sci. U.S.A. 2018
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created