ROS positively regulates misfolding of cilia proteins

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R-HSA-9639698
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Homo sapiens
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Accumulation of excessive reactive oxygen species (ROS) within cells results in oxidative stress. This stress can trigger proteins misfolding and make them dysfunctional. Cilia proteins are damaged when subjected to oxidative stress and may be targeted to the autophagy machinery. This results in the shortening of the cilium (Lam HC et al. 2013, Kim JI et al. 2013). Experiments leading to this finding were performed in mice.

Literature References
PubMed ID Title Journal Year
24200693 Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

Lam, HC, Cloonan, SM, Bhashyam, AR, Haspel, JA, Singh, A, Sathirapongsasuti, JF, Cervo, M, Yao, H, Chung, AL, Mizumura, K, An, CH, Shan, B, Franks, JM, Haley, KJ, Owen, CA, Tesfaigzi, Y, Washko, GR, Quackenbush, J, Silverman, EK, Rahman, I, Kim, HP, Mahmood, A, Biswal, SS, Ryter, SW, Choi, AM

J. Clin. Invest. 2013
23515720 Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys

Kim, JI, Kim, J, Jang, HS, Noh, MR, Lipschutz, JH, Park, KM

Am. J. Physiol. Renal Physiol. 2013
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