v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine

Stable Identifier
R-HSA-9640168
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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RRAGA:GTP (RagA:GTP) binds poorly to SLC38A9, therefore SLC39A9 is believed to dissociate from RRAGA:GTP after RRAGA exchanges GDP for GTP (Shen and Sabatini 2018). In this way one molecule of SLC38A9 can enhance the exchange of GDP for GTP for many molecules of RRAGA (Shen and Sabatini 2018).

Literature References
PubMed ID Title Journal Year
30181260 Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Shen, K, Sabatini, DM

Proc. Natl. Acad. Sci. U.S.A. 2018
Participants
Participant Of
Orthologous Events
Authored
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Created