Reactome | v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

Stable Identifier

R-HSA-9640175

Type

Reaction [binding]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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General

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v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

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The N-terminal domain of SLC38A9 bound to L-arginine interacts indirectly with the Ragulator complex via the Rag GTPases RRAGA and RRAGC (Wang et al. 2015, Rebsamen et al. 2015, Wyant et al. 2017, Shen and Sabatini 2018).

Literature References

PubMed ID	Title	Journal	Year
30181260	Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms Sabatini, DM, Shen, K	Proc. Natl. Acad. Sci. U.S.A.	2018
25567906	Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 Sabatini, DM, Wang, T, Zoncu, R, Jones, TD, Comb, W, Park, J, Straub, C, Wang, S, Shen, K, Tsun, ZY, Bar-Peled, L, Plovanich, ME, Chantranupong, L, Sabatini, BL, Kim, C, Yuan, ED, Wyant, GA, Wolfson, RL	Science	2015
25561175	SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 Bigenzahn, JW, Huber, KV, Indiveri, C, Bennett, KL, Rebsamen, M, Superti-Furga, G, Kandasamy, RK, Rudashevskaya, EL, Snijder, B, Galluccio, M, Huber, LA, Heinz, LX, de Araújo, ME, Pochini, L, Fauster, A, Filipek, PA, Bruckner, M, Scorzoni, S, Kraft, C, Stasyk, T	Nature	2015
29053970	mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient Chen, WW, Sabatini, DM, Danai, LV, Abu-Remaileh, M, Wyant, GA, Vander Heiden, MG, Freinkman, E, Wolfson, RL	Cell	2017