Parkin binds Ub:UBE2N:UBE2V1

Stable Identifier
R-HSA-9641089
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Ubiquitination is the covalent attachment of ubiquitin molecules to substrate proteins with three enzymatic steps - E1 ubiquitin activation, E2 ubiquitin conjugation and E3 ubiquitin protein ligase. UBE2V1 and UBE2N are E2 ubiquitin-conjugating enzymes that form a complex and bind ubiquitin molecules at K63. Consequently, the E3 ligase PRKN (Parkin) binds this complex and facilitates the addition of more ubiquitin molecules. (Olzmann JA et al. 2007).

Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Olzmann, JA, Li, L, Chudaev, MV, Chen, J, Perez, FA, Palmiter, RD, Chin, LS

J. Cell Biol. 2007
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