Reactome | Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency

Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency

Stable Identifier

R-HSA-9644926

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency

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The DDIT3 (CHOP) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Bartlett et al. 1992, Carlson et al. 1993, Bruhat et al. 1997, Yoshida et al. 2000, Lee et al. 2008, Sikalidis et al. 2011). In response to amino acid starvation, transcription of DDIT3 s enhanced by ATF4 and phosphorylated ATF2 (Bruhat et al. 2000, Averous et al. 2004, Bruhat et al. 2007). In mouse, expression of Ddit3 is activated by DNA damage and by NF-Y and Atf4 in response to endoplasmic reticulum stress.

Literature References

PubMed ID	Title	Journal	Year
18285520	HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway Dominy, JE, Sikalidis, AK, Lee, JI, Stipanuk, MH, Hirschberger, LL, Wang, W	Physiol. Genomics	2008
17267404	ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation Bruhat, A, Cherasse, Y, Fafournoux, P, Jousse, C, Jones, N, Maurin, AC, Parry, L, Breitwieser, W, Deval, C	Nucleic Acids Res.	2007
14630918	Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation Jousse, C, Carraro, V, Fafournoux, P, Averous, J, Thiel, G, Bruhat, A	J Biol Chem	2004
1400365	Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability Holbrook, NJ, Carlson, SG, Luethy, JD, Sollott, SJ, Bartlett, JD	J. Biol. Chem.	1992
20361218	Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium Sikalidis, AK, Lee, JI, Stipanuk, MH	Amino Acids	2011
8336711	Regulation of the C/EBP-related gene gadd153 by glucose deprivation Holbrook, NJ, Carlson, SG, Bernier, M, Bartlett, JD, Fawcett, TW	Mol. Cell. Biol.	1993
9211906	Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels Ferrara, M, Ron, D, Wang, XZ, Bruhat, A, Fafournoux, P, Jousse, C	J. Biol. Chem.	1997
10982836	Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter Ferrara, M, Carraro, V, Bruhat, A, Fafournoux, P, Jousse, C, Reimold, AM	Mol. Cell. Biol.	2000