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p14ARF [cytosol]
Stable Identifier
R-HSA-9645669
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cyclin-dependent kinase inhibitor 2A, isoform 4, p19ARF
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
p14ARF translocates to the nucleus (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
p14ARF translocates to the nucleus (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)
p14ARF:C1QBP [cytosol] (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
p14ARF binds C1QBP (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
p14ARF:C1QBP [cytosol] (Homo sapiens)
p14ARF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N726 CDKN2A
Gene Names
CDKN2A, CDKN2, MLM, MTS1
Chain
chain:1-132
Reference Genes
BioGPS Gene:1029 CDKN2A
COSMIC (genes):CDKN2A CDKN2A
CTD Gene:1029 CDKN2A
dbSNP Gene:1029 CDKN2A
ENSEMBL:ENSG00000147889 CDKN2A
HGNC:1787 CDKN2A
Monarch:1029 CDKN2A
NCBI Gene:1029 CDKN2A
OMIM:600160 CDKN2A
UCSC:Q8N726 CDKN2A
Reference Transcript
RefSeq:NM_058195.3 CDKN2A
Other Identifiers
1029
11718293_a_at
11753744_a_at
11753745_x_at
1713_s_at
207039_PM_at
207039_at
209644_PM_x_at
209644_x_at
211156_PM_at
211156_at
3201444
3201445
3201446
3201447
3201448
3201450
3201451
3201452
3201453
3201454
3201455
3201456
3201457
3201458
3201459
3201460
3201461
3201464
3201465
3201466
3201467
3201472
3201473
3201474
3201477
3201478
3201480
3201481
3201483
3201485
49757_at
73130_s_at
73132_r_at
8160441
A_23_P43484
A_23_P43490
A_33_P3411628
GE59038
GE897374
GO:0000209
GO:0001953
GO:0002039
GO:0003677
GO:0003723
GO:0003824
GO:0004861
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006355
GO:0006364
GO:0006915
GO:0006919
GO:0007005
GO:0007265
GO:0008285
GO:0008637
GO:0010628
GO:0012501
GO:0016604
GO:0016740
GO:0016925
GO:0019789
GO:0019901
GO:0030308
GO:0030575
GO:0030889
GO:0031647
GO:0031648
GO:0032088
GO:0032991
GO:0033088
GO:0033235
GO:0034393
GO:0034504
GO:0035985
GO:0042326
GO:0043065
GO:0043226
GO:0043517
GO:0045736
GO:0045892
GO:0045893
GO:0045944
GO:0046825
GO:0048103
GO:0050821
GO:0051059
GO:0051444
GO:0051726
GO:0055105
GO:0061629
GO:0070534
GO:0090398
GO:0090399
GO:0097371
GO:0097718
GO:0098772
GO:0140096
GO:1900182
GO:1901798
GO:1902510
GO:1902570
GO:1904667
GO:1990000
GO:1990948
GO:2000045
GO:2000059
GO:2000111
GO:2000435
HMNXSV003019577
ILMN_1717714
ILMN_1744295
ILMN_1757255
PH_hs_0019731
PH_hs_0039700
U26727_at
g1353569_3p_a_at
g1353569_3p_x_at
g4206166_3p_a_at
g4502748_3p_at
Participates
as an input of
p14ARF translocates to the nucleus (Homo sapiens)
p14ARF binds C1QBP (Homo sapiens)
as an output of
Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)
as a component of
p14ARF:C1QBP [cytosol] (Homo sapiens)
Other forms of this molecule
p14ARF [nucleoplasm]
p14ARF [mitochondrial matrix]
p14ARF R98L;R99S [cytosol]
p14ARF R82C [cytosol]
p14ARF R90H [cytosol]
p14ARF R88Q [cytosol]
p14ARF R87C [cytosol]
p14ARF R81G [cytosol]
p14ARF R98Q [cytosol]
p14ARF R99C [cytosol]
p14ARF V22Pfs*46 [cytosol]
Cross References
RefSeq
NP_478102.2
OpenTargets
ENSG00000147889
ENSEMBL
ENST00000530628
,
ENSP00000432664
,
ENSP00000462950
PRO
Q8N726
Pharos - Targets
Q8N726
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.813
5
UniProt:Q7Z6Z7 HUWE1
4
HUWE1 [ficolin-1-rich granule lumen]
(R-HSA-6801467)
HUWE1 [extracellular region]
(R-HSA-6806466)
HUWE1 [secretory granule lumen]
(R-HSA-6801481)
HUWE1 [cytosol]
(R-HSA-975983)
0.677
5
IntAct:EBI-4399559 UBIQ
0.667
3
UniProt:Q8TAQ5 ZNF420
2
p-S68-ZNF420 [nucleoplasm]
(R-HSA-6799095)
ZNF420 [nucleoplasm]
(R-HSA-1247509)
0.644
8
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.623
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.611
8
UniProt:Q14669 TRIP12
1
TRIP12 [cytosol]
(R-HSA-976046)
0.602
4
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.564
2
UniProt:P04198 MYCN
1
MYCN [nucleoplasm]
(R-HSA-452357)
0.556
3
UniProt:Q07021 C1QBP
3
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [cytosol]
(R-HSA-9645690)
0.556
3
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.544
4
UniProt:Q8AZK7 EBNA5
0.543
5
UniProt:P18146 EGR1
1
EGR1 [nucleoplasm]
(R-HSA-1031703)
0.524
4
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