Reactome | C1QBP [cytosol]

C1QBP [cytosol]

Stable Identifier

R-HSA-9645690

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

C1q binding protein, p32

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function (Homo sapiens)
      - p14ARF mutants do not bind C1QBP (Homo sapiens)
        
        C1QBP homotrimer [cytosol] (Homo sapiens)
        
        C1QBP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07021 C1QBP

Gene Names

C1QBP, GC1QBP, HABP1, SF2P32

Chain

transit peptide:1-73, chain:74-282

Reference Genes

BioGPS Gene:708 C1QBP

COSMIC (genes):C1QBP C1QBP

CTD Gene:708 C1QBP

dbSNP Gene:708 C1QBP

ENSEMBL:ENSG00000108561 C1QBP

HGNC:1243 C1QBP

KEGG:hsa:708 C1QBP

Monarch:708 C1QBP

NCBI Gene:708 C1QBP

OMIM:601269 C1QBP

UCSC:Q07021 C1QBP

Reference Transcript

RefSeq:NM_001212.3 C1QBP

Participates

as a candidate of

as a component of

C1QBP homotrimer [cytosol] (Homo sapiens)

Other forms of this molecule

C1QBP [mitochondrial matrix]

C1QBP [plasma membrane]

Inferred To

MAM33 [cytosol] (Saccharomyces cerevisiae)

P32 [cytosol] (Drosophila melanogaster)

c1qbp [cytosol] (Xenopus tropicalis)

C1qbp [cytosol] (Mus musculus)

C1qbp [cytosol] (Rattus norvegicus)

cri-3 [cytosol] (Caenorhabditis elegans)

C1QBP [cytosol] (Bos taurus)

C1QBP [cytosol] (Canis familiaris)

C1QBP [cytosol] (Gallus gallus)

C1QBP [cytosol] (Schizosaccharomyces pombe)

C1QBP [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000108561

ENSEMBL

ENSG00000108561, ENSP00000225698, ENST00000225698

HPA

ENSG00000108561-C1QBP

GeneCards

C1QBP

PRO

Q07021

Pharos - Targets

Q07021

GlyGen

Q07021

PDB

6SZW, 1P32, 7TE3, 3RPX

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.918	13
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.767	10
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.669	4
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.643	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.643	3
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.61	6
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.589	5
UniProt:Q14739 LBR	4	LBR [endosome membrane] (R-HSA-9715094) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [nuclear envelope] (R-HSA-194637)	0.564	2
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.564	2
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.556	3
UniProt:P01042 KNG1	8	Bradykinin [extracellular region] (R-HSA-158344) KNG1(19-644) [platelet alpha granule lumen] (R-HSA-139864) KNG1(19-644) [extracellular region] (R-HSA-158125) KNG1(19-644) [plasma membrane] (R-HSA-158269) KNG1(390-644) [plasma membrane] (R-HSA-158279) KNG1(19-380) [plasma membrane] (R-HSA-158245) KNG1 [endoplasmic reticulum lumen] (R-HSA-8956767) p-KNG1 [endoplasmic reticulum lumen] (R-HSA-8956939)	0.544	4
UniProt:P50281 MMP14	4	MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472) MMP14 [Golgi membrane] (R-HSA-9858808)	0.544	2
UniProt:Q9UBX2 DUX4	1	DUX4 [nucleoplasm] (R-HSA-9816412)	0.536	2
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:P13725 OSM	1	OSM [extracellular region] (R-HSA-5696440)	0.527	3
UniProt:Q86SE8 NPM2	1	NPM2 [nucleoplasm] (R-HSA-9821980)	0.527	2
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.527	2
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.527	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	3
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	13
UniProt:P01008 SERPINC1	8	SERPINC1(426-464) [extracellular region] (R-HSA-140817) SERPINC1(33-425) [extracellular region] (R-HSA-140814) SERPINC1 [endoplasmic reticulum lumen] (R-HSA-8956773) p-SERPINC1 [endoplasmic reticulum lumen] (R-HSA-8957069) SERPINC1 [extracellular region] (R-HSA-140807) SERPINC1 [plasma membrane] (R-HSA-140792) SERPINC1(426-464) [plasma membrane] (R-HSA-140816) SERPINC1(33-425) [plasma membrane] (R-HSA-140815)	0.462	3
UniProt:P00734 F2	11	thrombin light chain [extracellular region] (R-HSA-140598) thrombin heavy chain [extracellular region] (R-HSA-140589) 10xCbxE-F2(44-622) [extracellular region] (R-HSA-140674) 10xCbxE-F2(44-327) [extracellular region] (R-HSA-140786) thrombin light chain [plasma membrane] (R-HSA-140810) thrombin heavy chain [plasma membrane] (R-HSA-140809) F2(25-622) [endoplasmic reticulum lumen] (R-HSA-159739) 10xCbxE-F2(25-622) [endoplasmic reticulum lumen] (R-HSA-159800) 10xCbxE-F2(25-622) [Golgi lumen] (R-HSA-159841) 10xCbxE-F2(44-622) [Golgi lumen] (R-HSA-159845) prothrombin (factor II) propeptide [Golgi lumen] (R-HSA-159759)	0.462	3

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