PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1

Stable Identifier
R-HSA-9646347
Type
Reaction [binding]
Species
Homo sapiens
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When the proteasome machinery is deregulated, misfolded proteins are eliminated by forming aggresomes. To this end, poly-ubiquitinated misfolded proteins bind to a complex comprising of Transitional endoplasmic reticulum ATPase (VCP), Histone deacetylase 6 (HDAC6), Heat shock protein HSP 90 (HSP90) and Heat shock factor protein 1 (HSF1). HDAC6 in the complex interacts with the ubiquitin molecules in the misfolded proteins. Following this binding event, this complex starts dissociating (Boyault C et al. 2007).

Literature References
PubMed ID Title Journal Year
17785525 HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

Boyault, C, Zhang, Y, Fritah, S, Caron, C, Gilquin, B, Kwon, SH, Garrido, C, Yao, TP, Vourc'h, C, Matthias, P, Khochbin, S

Genes Dev. 2007
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