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Dynein motors transport misfolded proteins
Stable Identifier
R-HSA-9646383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
microtubule organizing center
,
cytosol
ReviewStatus
5/5
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Aggrephagy (Homo sapiens)
Dynein motors transport misfolded proteins (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Misfolded proteins are transported from the microtubule to the microtubule-organizing center (MTOC) in a dynein-mediated mechanism. Dynein motors carry the cargo along the microtubules from the plus end to the minus end (Garcia Mata R et al. 1999). Confirmatory experiments were performed in grivet cell lines.
Literature References
PubMed ID
Title
Journal
Year
10491388
Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera
Bebök, Z
,
Sztul, ES
,
García-Mata, R
,
Sorscher, EJ
J. Cell Biol.
1999
Participants
Input
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [cytosol]
(Homo sapiens)
Output
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center]
(Homo sapiens)
Participates
as an event of
Aggrephagy (Homo sapiens)
Inferred From
Dynein motors transport misfolded proteins (Cercopithecus aethiops)
Authored
Varusai, TM (2019-05-23)
Reviewed
Metzakopian, E (2019-05-24)
Created
Varusai, TM (2019-05-23)
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