Misfolded proteins:HDAC6:Dynein motor binds microtubule

Stable Identifier
R-HSA-9646390
Type
Reaction [binding]
Species
Homo sapiens
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Histone deacetylase 6 (HDAC6) binds misfolded proteins destined to form aggresomes and subsequently delivers this to dynein motor proteins. HDAC6 can also bind to microtubules thereby anchoring the misfolded proteins and the dynein motor to the microtubule (Hubbert C et al. 2002). Following this, the dynein motors traverse the microtubule to reach the microtubule-organizing center (MTOC).

Literature References
PubMed ID Title Journal Year
12024216 HDAC6 is a microtubule-associated deacetylase

Hubbert, C, Guardiola, A, Shao, R, Kawaguchi, Y, Ito, A, Nixon, A, Yoshida, M, Wang, XF, Yao, TP

Nature 2002
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