Aggresome dissociates from dynein and microtubule

Stable Identifier
R-HSA-9646685
Type
Reaction [dissociation]
Species
Homo sapiens
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Misfolded proteins are transformed into aggresomes at the microtubule organizing center. Dynein motor proteins facilitate the transport of misfolded proteins along the microtubule. Subsequently, the system disassembles to release the aggresome. The aggresome then recruits chaperone to be degraded by the autophagy machinery (Garcia Mata R et al. 1999).

Literature References
PubMed ID Title Journal Year
10491388 Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

García-Mata, R, Bebök, Z, Sorscher, EJ, Sztul, ES

J. Cell Biol. 1999
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