Reactome | p-6Y-ERBB2 H878Y [plasma membrane]

p-6Y-ERBB2 H878Y [plasma membrane]

Stable Identifier

R-HSA-9647215

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-6Y-HER2 H878Y, p-6Y-ERBB2 His878Tyr, p-6Y-HER2 His878Tyr

Icon

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
22046346	Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib Kancha, RK, von Bubnoff, N, Bartosch, N, Peschel, C, Engh, RA, Duyster, J	PLoS ONE	2011
26375550	Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor Hu, Z, Hu, Y, Liu, X, Xi, R, Zhang, A, Liu, D, Xie, Q, Chen, L	Oncotarget	2015
25853726	Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity Hu, Z, Wan, X, Hao, R, Zhang, H, Li, L, Li, L, Xie, Q, Wang, P, Gao, Y, Chen, S, Wei, M, Luan, Z, Zhang, A, Huang, N, Chen, L	PLoS ONE	2015

External Reference Information

External Reference

UniProt:P04626 ERBB2

Gene Names

ERBB2, HER2, MLN19, NEU, NGL

Chain

signal peptide:1-22, chain:23-1255

Reference Genes

BioGPS Gene:2064 ERBB2

COSMIC (genes):ERBB2 ERBB2

CTD Gene:2064 ERBB2

dbSNP Gene:2064 ERBB2

ENSEMBL:ENSG00000141736 ERBB2

HGNC:3430 ERBB2

KEGG Gene (Homo sapiens):2064 ERBB2

Monarch:2064 ERBB2

NCBI Gene:2064 ERBB2

OMIM:164870 ERBB2

UCSC:P04626 ERBB2

Reference Transcript

Other Identifiers

0106040504

1060

11736472_a_at

11750611_a_at

11751416_a_at

11755005_a_at

11762165_x_at

1338

1383

16833839

1802_s_at

1901_s_at

1MFG

1MFL

1MW4

1N8Z

1OVC

1QR1

1S78

20416

2064

210930_3p_s_at

210930_s_at

216836_s_at

2A91

2JWA

2KS1

2L4K

2N2A

33218_at

3720403

3720404

3720405

3720406

3720407

3720408

3720410

3720411

3720412

3720413

3720417

3720420

3720422

3720423

3720425

3720427

3720428

3720431

3720432

3720433

3720434

3720436

3720438

3720440

3720442

3720444

3720446

3720447

3720449

3720452

3720454

3720455

3720457

3720458

3720460

3720461

3720462

3720463

3720464

3720465

3720466

3720467

3720468

3720469

3720470

3720471

3BE1

3H3B

3MZW

3N85

3PP0

3RCD

3WLW

3WSQ

4GFU

4HRL

4HRM

4HRN

5K33

5KWG

5MY6

5O4G

5OB4

5TQS

62555

6ATT

6BGT

6J71

8006906

A_14_P101724

A_14_P126019

A_23_P89249

A_24_P284420

A_33_P3292596

AAA35808

AAA35809

AAA35978

AAA58637

AAA75493

AAC37531

AAI67147

AAO18082

AH001455

AHW56471

AHW56604

AK295195

AY208911

B4DTR1

BAG58195

BC167147

CAA27060

CAB000043

CAB020416

CAB062555

CCDS32642

CCDS45667

CCDS74052

CH471152

EAW60597

ENSG00000141736

ENSP00000269571

ENSP00000385185

ENSP00000446466

ENSP00000462438

ENSP00000463427

ENSP00000463714

ENST00000269571

ENST00000269571.9

ENST00000406381

ENST00000406381.6

ENST00000541774

ENST00000541774.5

ENST00000578373

ENST00000584450

ENST00000584601

ENST00000584601.5

EntrezGene:2064

EntrezGene:ERBB2

ERBB2

ERBB2-201

ERBB2-202

ERBB2-204

ERBB2-219

F5H1T4

g10181232_3p_a_at

GE57810

GO:0000165

GO:0000166

GO:0000902

GO:0001042

GO:0001934

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005887

GO:0006357

GO:0006412

GO:0006464

GO:0006468

GO:0006605

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0007399

GO:0007422

GO:0007507

GO:0007528

GO:0008022

GO:0008045

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0009925

GO:0010008

GO:0010628

GO:0014065

GO:0015031

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019838

GO:0019899

GO:0019903

GO:0030154

GO:0030182

GO:0030307

GO:0031410

GO:0032886

GO:0032991

GO:0033088

GO:0034641

GO:0035556

GO:0038128

GO:0040007

GO:0040011

GO:0042060

GO:0042552

GO:0042802

GO:0043125

GO:0043167

GO:0043209

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043547

GO:0045727

GO:0045765

GO:0045785

GO:0045943

GO:0046777

GO:0046982

GO:0046983

GO:0048471

GO:0048646

GO:0048709

GO:0048856

GO:0048870

GO:0050679

GO:0051897

GO:0070372

GO:0071363

GO:0071364

GO:0090314

GO:1901185

GO:2000145

HGNC:3430

HPA001060

HPA001338

HPA001383

Hs.323910.2.A1_3p_a_at

ILMN_1694303

ILMN_1717902

ILMN_1728761

ILMN_2352131

ILMN_3268199

IPR000494

IPR000719

IPR001245

IPR006211

IPR006212

IPR008266

IPR009030

IPR011009

IPR016245

IPR017441

IPR020635

IPR032778

IPR036941

J3KRI9

J3QL83

J3QLU9

J3QLV2

KJ534831

KJ534964

L29395

LRG_724

LRG_724t1

LRG_724t2

LRG_724t4

M11730

M12036

M16789

M16790

M16791

M16792

M95667

MIM:137800

MIM:164870

MIM:211980

MIM:613659

NM_001005862

NM_001289936

NM_004448

NP_001005862

NP_001276865

NP_004439

PF00757

PF01030

PF07714

PF14843

PH_hs_0021933

PR00109

SM00219

SM00261

TC17000480.hg

UPI000003F55F

UPI0000200C04

UPI0001D322F0

X03363

X03363_s_at

X5DNK3

XM_024450641

XM_024450642

XM_024450643

XP_024306409

XP_024306410

XP_024306411

Participant Of

hasMember

Other forms of this molecule

p-Y-ERBB2 L755P [plasma membrane]

p-Y-ERBB2 I767M [plasma membrane]

p-Y-ERBB2 A775_G776insYVMA [plasma membrane]

p-Y-ERBB2 T798I [plasma membrane]

p-Y-ERBB2 T862A [plasma membrane]

p-Y-ERBB2 T798M [plasma membrane]

p-Y-ERBB2 H878Y [plasma membrane]

p-Y-ERBB2 V777L [plasma membrane]

p-Y-ERBB2 L755S [plasma membrane]

p-Y-ERBB2 V777E [plasma membrane]

p-Y-ERBB2 V777M [plasma membrane]

p-Y-ERBB2 L755M [plasma membrane]

p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]

p-Y-ERBB2 L755W [plasma membrane]

p-Y-ERBB2 T733I [plasma membrane]

p-Y-ERBB2 H878R [plasma membrane]

p-Y-ERBB2 L869R [plasma membrane]

p-Y-ERBB2 G776S [plasma membrane]

p-Y-ERBB2 L869Q [plasma membrane]

p-Y-ERBB2 G776L [plasma membrane]

p-Y-ERBB2 G776V [plasma membrane]

p-Y-ERBB2 G776C [plasma membrane]

ERBB2 D769Y [plasma membrane]

ERBB2 L755P [plasma membrane]

ERBB2 V842I [plasma membrane]

ERBB2 H878Y [plasma membrane]

ERBB2 T798M [plasma membrane]

ERBB2 D769H [plasma membrane]

ERBB2 T862A [plasma membrane]

ERBB2 A775_G776insYVMA [plasma membrane]

ERBB2 L755S [plasma membrane]

ERBB2 I767M [plasma membrane]

ERBB2 V777L [plasma membrane]

ERBB2 D769N [plasma membrane]

ERBB2 T733I [plasma membrane]

ERBB2 V777M [plasma membrane]

ERBB2 V777E [plasma membrane]

ERBB2 L755W [plasma membrane]

ERBB2 L755M [plasma membrane]

ERBB2 A771_Y772insYVMA [plasma membrane]

ERBB2 H878R [plasma membrane]

ERBB2 V842E [plasma membrane]

ERBB2 T798I [plasma membrane]

ERBB2 R896C [plasma membrane]

ERBB2 P780_Y781insGSP [plasma membrane]

ERBB2 R896H [plasma membrane]

ERBB2 G778_P780insGSP [plasma membrane]

ERBB2 G776S [plasma membrane]

ERBB2 L869R [plasma membrane]

ERBB2 L869Q [plasma membrane]

ERBB2 G776C [plasma membrane]

ERBB2 G776L [plasma membrane]

ERBB2 G776V [plasma membrane]

p-6Y-ERBB2 V777L [plasma membrane]

ERBB2 L755_T759del [plasma membrane]

p-6Y-ERBB2 R896C [plasma membrane]

p-6Y-ERBB2 V842I [plasma membrane]

p-6Y-ERBB2 I767M [plasma membrane]

p-6Y-ERBB2 T862A [plasma membrane]

p-6Y-ERBB2 D769H [plasma membrane]

p-6Y-ERBB2 T798I [plasma membrane]

p-6Y-ERBB2 L755P [plasma membrane]

p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]

p-6Y-ERBB2 L755S [plasma membrane]

p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]

p-6Y-ERBB2 T798M [plasma membrane]

p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]

p-6Y-ERBB2 D769Y [plasma membrane]

p-6Y-ERBB2 V777E [plasma membrane]

p-6Y-ERBB2 T733I [plasma membrane]

p-6Y-ERBB2 L755M [plasma membrane]

p-6Y-ERBB2 V777M [plasma membrane]

p-6Y-ERBB2 V842E [plasma membrane]

p-6Y-ERBB2 D769N [plasma membrane]

p-6Y-ERBB2 R896H [plasma membrane]

p-6Y-ERBB2 L755W [plasma membrane]

p-6Y-ERBB2 G778_P780insGSP [plasma membrane]

p-6Y-ERBB2 H878R [plasma membrane]

p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

ERBB2 [plasma membrane]

p-Y877-ERBB2 [plasma membrane]

p-6Y-ERBB2 [plasma membrane]

p-6Y,Y1112-ERBB2 [plasma membrane]

p-Y-ERBB2 [plasma membrane]

p-Y,Y877-ERBB2 [plasma membrane]

p-7Y,Y1112-ERBB2 [plasma membrane]

p-7Y-ERBB2 [plasma membrane]

Modified Residues

Name

L-histidine 878 replaced with L-tyrosine

Coordinate

878

PsiMod

L-histidine removal [MOD:01639]

A protein modification that effectively removes or replaces an L-histidine.

L-tyrosine residue

A protein modification that effectively converts a source amino acid residue to L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1023

Coordinate

1023

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1139

Coordinate

1139

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1196

Coordinate

1196

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1221

Coordinate

1221

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1222

Coordinate

1222

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1248

Coordinate

1248

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 878

Coordinate

878

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
hepatocellular carcinoma	684	adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
urinary system cancer	3996
cancer	162	malignant tumor, malignant neoplasm, primary cancer
breast cancer	1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor

Cross References

RefSeq

NP_001005862.1, NP_001276867.1, NP_001276865.1, NP_004439.2

ZINC - World Drugs

ERBB2_HUMAN

OpenTargets

ENSG00000141736

ZINC - FDA approved

ERBB2_HUMAN

ZINC - Substances

ERBB2_HUMAN

ZINC - Biogenic

ERBB2_HUMAN

ZINC target

P04626

PRO

P04626

PDB

5OB4, 5MY6, 4HRM, 1MFL, 1OVC, 1MW4, 3WSQ, 1S78, 5KWG, 5TQS, 4HRN, 2N2A, 2L4K, 4GFU, 2A91, 3H3B, 5K33, 6J71, 3PP0, 3WLW, 6BGT, 3BE1, 2JWA, 3RCD, 3MZW, 5O4G, 2KS1, 1N8Z, 3N85, 1MFG, 4HRL, 1QR1, 6OGE, 6ATT

ZINC - Investigational

ERBB2_HUMAN

ZINC - Metabolites

ERBB2_HUMAN

COSMIC

COSM21985

GeneCards

P04626

ZINC - Predictions - Purchasable

ERBB2_HUMAN

HMDB Protein

HMDBP01473

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21860 ERBB3			0.974	29
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.96	25
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.938	12
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.831	5
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.825	5
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.779	5
UniProt:Q15303 ERBB4			0.778	4
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) STAT3 [cytosol] (R-HSA-539044)	0.775	9
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.772	15
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.734	4
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.708	11
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.688	11
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937)	0.656	4
UniProt:P16885 PLCG2	10	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.609	3
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.609	7
UniProt:P42224 STAT1	7	p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.609	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.609	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.602	5
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.592	8
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.592	4
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563)	0.592	3
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.59	2
IntAct:EBI-4399559 UBIQ			0.589	2
UniProt:Q05397 PTK2	11	PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(1-772) [cytosol] (R-HSA-202827) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.589	2
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.567	16
UniProt:Q15075 EEA1	1	EEA1 [endosome membrane] (R-HSA-187893)	0.567	5
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.567	14
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.564	3
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.558	2
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.558	6
UniProt:O95980 RECK	2	GPI-RECK [plasma membrane] (R-HSA-8940687) cleaved GPI-RECK [extracellular region] (R-HSA-8941046)	0.556	4
UniProt:O75367 H2AY			0.556	6
UniProt:Q9UJM3 ERRFI			0.547	3
UniProt:P60709 ACTB	5	ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160)	0.537	10
UniProt:O95292 VAPB	1	VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.527	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	2
UniProt:P02786 TFRC	5	TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124)	0.527	2
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.525	2
UniProt:Q99952-1 PTPN18			0.524	5
IntAct:EBI-5590949 HAS			0.524	2
UniProt:Q15256 PTPRR			0.508	2
UniProt:P15309 ACPP	2	ACPP [azurophil granule membrane] (R-HSA-6799214) ACPP [plasma membrane] (R-HSA-3229238)	0.472	2
UniProt:P49792 RANBP2	4	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [cytosol] (R-HSA-157703) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.463	3
UniProt:P98172 EFNB1	2	EFNB1 [plasma membrane] (R-HSA-2682327) p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412)	0.463	11