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GSDMD(276-484) [cytosol]
Stable Identifier
R-HSA-9647672
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Gasdermin-D(276-484), Gasdermin-D, C-terminal, GSDMD_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
CASP1 cleaves GSDMD (Homo sapiens)
GSDMD(276-484) [cytosol] (Homo sapiens)
CASP4, CASP5 cleave GSDMD (Homo sapiens)
GSDMD(276-484) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P57764 GSDMD
Gene Names
GSDMD, DFNA5L, GSDMDC1, FKSG10
Chain
chain:1-484, chain:1-290, chain:1-275, chain:1-87, chain:276-484
Reference Genes
BioGPS Gene:79792 GSDMD
COSMIC (genes):GSDMD GSDMD
CTD Gene:79792 GSDMD
dbSNP Gene:79792 GSDMD
ENSEMBL:ENSG00000104518 GSDMD
ENSEMBL_homo_sapiens_GENE:ENSG00000104518.11 GSDMD
ENSEMBL_homo_sapiens_GENE:ENSG00000278718.3 GSDMD
HGNC:25697 GSDMD
KEGG Gene (Homo sapiens):79792 GSDMD
Monarch:79792 GSDMD
NCBI Gene:79792 GSDMD
OMIM:617042 GSDMD
UCSC:P57764 GSDMD
Reference Transcript
RefSeq:NM_001166237.1 GSDMD
RefSeq:NM_024736.6 GSDMD
Other Identifiers
11741138_a_at
17073370
218154_PM_at
218154_at
3119657
3119660
3119661
3119666
3119667
3119669
3119670
3119672
3119674
3119677
3119678
3119680
3119682
3119684
3119685
3119686
65139_at
65140_at
79792
8148642
A_14_P131372
A_14_P132308
A_23_P112103
GE61932
GO:0001786
GO:0002376
GO:0005215
GO:0005515
GO:0005546
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006954
GO:0008289
GO:0009306
GO:0012501
GO:0016020
GO:0022829
GO:0031410
GO:0031668
GO:0031966
GO:0032731
GO:0035580
GO:0042742
GO:0043226
GO:0045087
GO:0046931
GO:0050729
GO:0050829
GO:0050830
GO:0051260
GO:0055085
GO:0061702
GO:0065003
GO:0070269
GO:0070273
GO:0070300
GO:0072559
GO:0098542
GO:1901612
GO:1904724
GO:1904813
HMNXSV003034638
HMNXSV003044886
ILMN_1665428
PH_hs_0006565
TC08000824.hg
g13376057_3p_at
Participates
as an output of
CASP4, CASP5 cleave GSDMD (Homo sapiens)
CASP1 cleaves GSDMD (Homo sapiens)
Other forms of this molecule
GSDMD [specific granule lumen]
GSDMD [ficolin-1-rich granule lumen]
GSDMD [extracellular region]
GSDMD [tertiary granule lumen]
dithiocarb-C191-GSDMD(1-275) [cytosol]
GSDMD(88-484) [cytosol]
GSDMD(1-87) [cytosol]
GSDMD(1-275) [cytosol]
GSDMD [cytosol]
S-(2-succinyl)-C191-GSDMD [cytosol]
GSDMD(269-484) [cytosol]
GSDMD(1-268) [cytosol]
Inferred To
GSDMD [cytosol]
(Bos taurus)
GSDMD [cytosol]
(Canis familiaris)
GSDMD [cytosol]
(Sus scrofa)
GSDMD(276-484) [cytosol]
(Gallus gallus)
Gsdmd [cytosol]
(Mus musculus)
Gsdmd [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001159709.1
,
NP_079012.3
Guide to Pharmacology - Targets
3278
OpenTargets
ENSG00000104518
HPA
ENSG00000104518-GSDMD
GeneCards
P57764
Ensembl
ENST00000526406
,
ENSP00000482096
,
ENST00000615119
,
ENSP00000488012
,
ENSP00000262580
,
ENSG00000278718
,
ENST00000262580
,
ENSP00000433209
,
ENST00000631751
,
ENSG00000104518
PRO
P57764
Pharos - Targets
P57764
PDB
7Z1X
,
5NH1
,
6VFE
,
6AO4
,
5WQT
,
6KN0
,
6N9O
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.781
7
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.659
13
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.591
4
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.556
3
UniProt:Q86T24 KAISO
0.556
3
UniProt:Q86U10 ASPG
1
ASPG [cytosol]
(R-HSA-6797634)
0.556
3
UniProt:Q9BUY5 ZNF426
1
ZNF426 [nucleoplasm]
(R-HSA-1247530)
0.556
3
UniProt:Q96NG5 ZNF558
1
ZNF558 [nucleoplasm]
(R-HSA-1973893)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
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