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EML4 [cytosol]
Stable Identifier
R-HSA-9647741
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Echinoderm microtubule-associated protein-like 4, EMAL4_HUMAN, EMAP-4, Ropp 120, Restrictedly overexpressed proliferation-associated protein, C2orf2, EMAPL4
Locations in the PathwayBrowser for interactor UniProt:Q13885 TUBB2A
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 trimerizes (Homo sapiens)
EML4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HC35 EML4
Gene Names
EML4, C2orf2, EMAPL4
Chain
chain:1-981
Reference Genes
BioGPS Gene:27436 EML4
COSMIC (genes):EML4 EML4
CTD Gene:27436 EML4
dbSNP Gene:27436 EML4
ENSEMBL:ENSG00000143924 EML4
HGNC:1316 EML4
KEGG:hsa:27436 EML4
Monarch:27436 EML4
NCBI Gene:27436 EML4
OMIM:607442 EML4
UCSC:Q9HC35 EML4
Reference Transcript
RefSeq:NM_001145076.2 EML4
RefSeq:NM_019063.4 EML4
Other Identifiers
11716652_a_at
11716653_x_at
11716654_a_at
11747005_a_at
16879408
220386_PM_s_at
220386_s_at
223068_PM_at
223068_at
223069_PM_s_at
223069_s_at
228674_PM_s_at
228674_s_at
232587_PM_at
232587_at
2478749
2478750
2478751
2478763
2478771
2478772
2478776
2478777
2478778
2478780
2478781
2478787
2478789
2478791
2478792
2478793
2478794
2478797
2478798
2478799
2478801
2478802
2478805
2478806
2478807
2478808
2478810
2478816
2478818
2478820
2478821
2478822
2478826
2478829
2478830
2478833
2478834
2478835
2478836
2478837
2478838
2478839
2478840
2478841
2478842
2478843
2478844
2478862
27436
56562_at
62036_at
65041_at
66955_at
8041592
88181_at
A_14_P131775
A_23_P143127
A_24_P273413
GE55919
GE601267
GO:0000226
GO:0000278
GO:0003674
GO:0005515
GO:0005737
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007080
GO:0008017
GO:0008092
GO:0008608
GO:0015630
GO:0016020
GO:0030496
GO:0043014
GO:0043226
GO:0048487
GO:0051301
GO:0072686
HMNXSV003035398
HMNXSV003044133
Hs.12066.0.S1_3p_at
Hs.13472.1.A2_3p_at
Hs2.147135.1.S1_3p_s_at
ILMN_1718297
PH_hs_0024383
TC02000260.hg
g9506630_3p_a_at
g9957235_3p_a_at
Participates
as a component of
EML4 homotrimer [cytosol] (Homo sapiens)
as an input of
EML4 trimerizes (Homo sapiens)
Other forms of this molecule
p-S,T-EML4 [cytosol]
EML4(1-496)-ALK(1058-1620) fusion [cytosol]
EML4(1-223)-ALK(1059-1620) fusion [cytosol]
EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol]
EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol]
EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol]
EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol]
EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol]
EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol]
EML4(1-569)-ALK(1078-1620) fusion [cytosol]
EML4(1-780)-ALK(1058-1620) fusion [cytosol]
Inferred To
EML4 [cytosol]
(Bos taurus)
EML4 [cytosol]
(Canis familiaris)
EML4 [cytosol]
(Gallus gallus)
EML4 [cytosol]
(Sus scrofa)
eml4 [cytosol]
(Xenopus tropicalis)
elp-1 [cytosol]
(Caenorhabditis elegans)
Eml4 [cytosol]
(Mus musculus)
Eml4 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001138548.1
,
NP_061936.2
OpenTargets
ENSG00000143924
ENSEMBL
ENSP00000385059
,
ENST00000402711
,
ENSP00000320663
,
ENST00000318522
HPA
ENSG00000143924-EML4
PRO
Q9HC35
Pharos - Targets
Q9HC35
GlyGen
Q9HC35
PDB
4CGC
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q13885 TUBB2A
6
TUBB2A folding intermediate [cytosol]
(R-HSA-392802)
TUBB2A unfolded [cytosol]
(R-HSA-392776)
Polyglycyl-TUBB2A [cytosol]
(R-HSA-8867466)
Polyglutamyl-TUBB2A [cytosol]
(R-HSA-8867392)
TUBB2A [axonemal microtubule]
(R-HSA-5610431)
TUBB2A [cytosol]
(R-HSA-191699)
0.527
3
UniProt:Q9BVA1 TUBB2B
6
TUBB2B folding intermediate [cytosol]
(R-HSA-392796)
TUBB2B unfolded [cytosol]
(R-HSA-392768)
Polyglycyl-TUBB2B [cytosol]
(R-HSA-8867393)
Polyglutamyl-TUBB2B [cytosol]
(R-HSA-8867426)
TUBB2B [axonemal microtubule]
(R-HSA-5610432)
TUBB2B [cytosol]
(R-HSA-191705)
0.527
3
UniProt:Q9NVF7 FBX28
0.527
5
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.527
3
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.527
2
UniProt:Q13509 TUBB3
6
TUBB3 [cytosol]
(R-HSA-190532)
TUBB3 [axonemal microtubule]
(R-HSA-5610436)
Polyglutamyl-TUBB3 [cytosol]
(R-HSA-8867464)
Polyglycyl-TUBB3 [cytosol]
(R-HSA-8867372)
TUBB3 unfolded [cytosol]
(R-HSA-392770)
TUBB3 folding intermediate [cytosol]
(R-HSA-392806)
0.527
2
UniProt:Q8TDX7 NEK7
2
NEK7 [cytosol]
(R-HSA-2530599)
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
0.508
2
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