EML4 trimerizes

Stable Identifier
R-HSA-9647746
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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EML4 trimerizes
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EML4, a microtubule binding protein involved in mitotic spindle formation, forms homotrimers. Trimerization involves the trimerization domain (TD) and the basic region of EML4 and is necessary for its association with the microtubules (Richards et al. 2015). Heterotrimerization of EML4 with other EML family members has not been examined.
Literature References
PubMed ID Title Journal Year
25740311 Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

O'Regan, L, Richards, MW, Bayliss, R, Fry, AM, Straube, A, Montgomery, JM, Roth, D

Biochem. J. 2015
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Authored
Orlic-Milacic, M  (2019-06-25)
Reviewed
Fry, AM  (2019-09-30)
Bechstedt, S  (2019-10-03)
Lucken, KJ  (2019-09-30)
O'Regan, L  (2019-09-30)
Created
Orlic-Milacic, M  (2019-06-03)
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