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About
What is Reactome ?
News
Team
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
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Table of Contents
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S-Farn-Me HRAS [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-9647796
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Ras, p21/H-RAS-1 , Transforming protein p21/H-Ras-1, c-H-ras
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
ICMT methylates S-Farn RAS proteins (Homo sapiens)
S-Farn-Me RAS [endoplasmic reticulum membrane] (Homo sapiens)
S-Farn-Me HRAS [endoplasmic reticulum membrane] (Homo sapiens)
S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)
S-Farn Me KRAS4A, HRAS, NRAS [endoplasmic reticulum membrane] (Homo sapiens)
S-Farn-Me HRAS [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01112 HRAS
Gene Names
HRAS, HRAS1
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3265 HRAS
COSMIC (genes):HRAS HRAS
CTD Gene:3265 HRAS
dbSNP Gene:3265 HRAS
ENSEMBL:ENSG00000174775 HRAS
ENSEMBL_homo_sapiens_GENE:ENSG00000174775.18 HRAS
ENSEMBL_homo_sapiens_GENE:ENSG00000276536.4 HRAS
HGNC:5173 HRAS
KEGG Gene (Homo sapiens):3265 HRAS
Monarch:3265 HRAS
NCBI Gene:3265 HRAS
OMIM:190020 HRAS
UCSC:P01112 HRAS
Reference Transcript
RefSeq:NM_001130442.2 HRAS
RefSeq:NM_176795.4 HRAS
RefSeq:NM_005343.3 HRAS
RefSeq:NM_001318054.1 HRAS
Other Identifiers
11733320_a_at
11744709_a_at
1590_s_at
16733952
212983_PM_at
212983_at
3265
3358091
3358092
3358093
3358094
3358096
3358097
3358098
3358099
3358100
3358103
35701_at
7945436
A_23_P98183
GE57461
GO:0000139
GO:0000165
GO:0000166
GO:0001934
GO:0002376
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006886
GO:0006897
GO:0006935
GO:0007010
GO:0007165
GO:0007166
GO:0007264
GO:0007265
GO:0008284
GO:0008285
GO:0008286
GO:0009887
GO:0010628
GO:0010629
GO:0010863
GO:0012501
GO:0014044
GO:0016020
GO:0016192
GO:0016787
GO:0019003
GO:0023052
GO:0030154
GO:0030335
GO:0032729
GO:0032956
GO:0034260
GO:0036211
GO:0042060
GO:0042088
GO:0042127
GO:0042552
GO:0042832
GO:0043226
GO:0043406
GO:0043410
GO:0043495
GO:0043524
GO:0043547
GO:0045944
GO:0046330
GO:0048144
GO:0048146
GO:0048169
GO:0048471
GO:0048856
GO:0048870
GO:0050679
GO:0050852
GO:0051402
GO:0051726
GO:0060090
GO:0060612
GO:0070374
GO:0071480
GO:0090303
GO:0090314
GO:0090398
GO:0090402
GO:0097193
GO:0098542
GO:0098696
GO:0098772
GO:0098978
GO:1900029
GO:1905360
GO:2000630
HMNXSV003016066
Hs.37003.0.S1_3p_at
Hs.37003.0.S1_3p_x_at
ILMN_1699798
ILMN_1773751
J00277_at
PH_hs_0031161
TC11001236.hg
V00574_s_at
Participates
as a member of
S-Farn Me KRAS4A, HRAS, NRAS [endoplasmic reticulum membrane] (Homo sapiens)
S-Farn-Me RAS [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
HRAS Q61R [plasma membrane]
HRAS Q61L [plasma membrane]
HRAS Q61K [plasma membrane]
HRAS G13R [plasma membrane]
HRAS G12V [plasma membrane]
HRAS G12S [plasma membrane]
HRAS T58I [plasma membrane]
HRAS G13C [plasma membrane]
HRAS K117R [plasma membrane]
HRAS G13V [plasma membrane]
HRAS G13D [plasma membrane]
HRAS G13S [plasma membrane]
HRAS K117N [plasma membrane]
HRAS G12D [plasma membrane]
HRAS G12C [plasma membrane]
HRAS [plasma membrane]
S-Farn-Me HRAS [plasma membrane]
S-Farn-Me PalmS HRAS [Golgi membrane]
S-Farn-HRAS [endoplasmic reticulum membrane]
S-Farn-proHRAS [endoplasmic reticulum membrane]
proHRAS [cytosol]
S-Farn-Me-2xPalmS HRAS [plasma membrane]
Inferred To
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(Bos taurus)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(Drosophila melanogaster)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(Gallus gallus)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(Mus musculus)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(Rattus norvegicus)
hrasb [endoplasmic reticulum membrane]
(Danio rerio)
HRAS [endoplasmic reticulum membrane]
(Canis familiaris)
HRAS [endoplasmic reticulum membrane]
(Sus scrofa)
Modified Residues
Name
S-farnesyl-L-cysteine methyl ester at 186
Coordinate
186
PsiMod Name
S-farnesyl-L-cysteine methyl ester
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester.
Cross References
RefSeq
NP_001304983.1
,
NP_001123914.1
,
NP_005334.1
,
NP_789765.1
Guide to Pharmacology - Targets
2822
OpenTargets
ENSG00000174775
ZINC - Substances
RASH_HUMAN
ZINC target
P01112
PRO
P01112
PDB
1CTQ
,
6V9N
,
8BE8
,
3RSL
,
421P
,
4DLW
,
8CNN
,
7DPJ
,
4DLT
,
621P
,
6CUP
,
1AA9
,
3LBN
,
4DLS
,
4URX
,
2QUZ
,
1XCM
,
3RS7
,
4URW
,
1PLL
,
1IAQ
,
5E95
,
4L9W
,
5B2Z
,
2EVW
,
121P
,
7VV9
,
1AGP
,
5WFO
,
2CLC
,
4DLY
,
6BVK
,
1ZVQ
,
8ELU
,
5ZC6
,
3K8Y
,
6D5L
,
6V9F
,
1PLK
,
2RGC
,
6D5M
,
2RGD
,
6DZH
,
4Q21
,
6V9L
,
1JAI
,
2UZI
,
8EM0
,
3KKN
,
4DST
,
2CL7
,
1P2V
,
3RS5
,
8ELX
,
5WFR
,
7VVG
,
8FG3
,
5VBE
,
3K9L
,
7JHP
,
7OGD
,
6MQT
,
4RSG
,
5P21
,
7OGE
,
7OGA
,
3RRY
,
8BEA
,
1CRR
,
8ELW
,
7OGF
,
4URY
,
3OIW
,
221P
,
5WPL
,
1K8R
,
6D5H
,
3RS2
,
721P
,
7TAM
,
2LCF
,
3RSO
,
4G0N
,
1PLJ
,
821P
,
7JII
,
8ELT
,
7DPH
,
3L8Z
,
6ZJ0
,
1LF5
,
4URZ
,
6BVL
,
4DLV
,
8TBG
,
6NTD
,
4NYI
,
7JIF
,
7OG9
,
3L8Y
,
1LFD
,
1QRA
,
5WFQ
,
6AMB
,
3RRZ
,
6Q21
,
3I3S
,
1RVD
,
8ELZ
,
1P2U
,
6D55
,
2CLD
,
8CNJ
,
4DLX
,
6D56
,
5WDQ
,
6NTC
,
1HE8
,
1XD2
,
7L0F
,
2RGB
,
1CLU
,
6D59
,
1CRQ
,
4US1
,
6CUO
,
6ZL3
,
7OGB
,
8ELV
,
5WDO
,
3LBI
,
4DLU
,
7JIG
,
3TGP
,
6V94
,
2RGA
,
1NVX
,
8BOS
,
7VV8
,
4DLR
,
3DDC
,
5X9S
,
6CUR
,
1JAH
,
1GNR
,
6BVJ
,
3LBH
,
8ELS
,
4URU
,
6D5J
,
4XVQ
,
2RGG
,
6V9O
,
4NYM
,
4L9S
,
2X1V
,
4G3X
,
8ELK
,
8BWG
,
4K81
,
6AXG
,
4DSU
,
2LWI
,
2CE2
,
6V9J
,
4NYJ
,
1NVW
,
3K9N
,
6D5E
,
4US0
,
6BVM
,
2CL6
,
6D5G
,
3OIV
,
3OIU
,
3RS4
,
6V9M
,
1P2T
,
4DLZ
,
3KKM
,
3RS3
,
2CL0
,
8BE7
,
521P
,
1BKD
,
2Q21
,
2RGE
,
4US2
,
1P2S
,
8FG4
,
5WDP
,
8BE9
,
1LF0
,
2N42
,
5VBZ
,
3LO5
,
2N46
,
4EFN
,
4EFM
,
6D5V
,
7L0G
,
2C5L
,
6D5W
,
1CRP
,
1XJ0
,
7OGC
,
1ZW6
,
3KUD
,
4EFL
,
1IOZ
,
1GNQ
,
6BVI
,
8ELR
,
4URV
,
7JIH
,
5B30
,
5WFP
,
3RS0
,
4XVR
,
6E6C
,
1GNP
,
1WQ1
,
6E6P
,
8ELY
,
2VH5
,
1NVU
,
8BE6
,
1NVV
,
1Q21
ZINC - Investigational
RASH_HUMAN
IntEnz
3.6.5.2
GeneCards
P01112
HPA
ENSG00000174775-HRAS
Ensembl
ENSG00000174775
,
ENSP00000488225
,
ENST00000493230
,
ENSP00000488296
,
ENST00000311189
,
ENST00000451590
,
ENST00000417302
,
ENSP00000407586
,
ENSP00000388246
,
ENSP00000380723
,
ENST00000397596
,
ENSP00000434023
,
ENST00000615062
,
ENST00000610977
,
ENSP00000482366
,
ENSG00000276536
,
ENSP00000488757
,
ENSP00000480317
,
ENSP00000309845
,
ENST00000616241
,
ENSP00000480686
,
ENST00000631967
,
ENST00000631404
,
ENST00000634098
Pharos - Targets
P01112
ZINC - Predictions - Purchasable
RASH_HUMAN
Orphanet
16221
HMDB Protein
HMDBP01958
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.978
30
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.938
11
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.904
8
UniProt:Q9NZL6 RGL1
1
RGL1 [cytosol]
(R-HSA-561160)
0.744
4
UniProt:Q12967 RALGDS
1
RALGDS [cytosol]
(R-HSA-171001)
0.683
3
UniProt:Q8WUX9 CHMP7
2
CHMP7 [cytosol]
(R-HSA-917703)
CHMP7 [endosome membrane]
(R-HSA-9631168)
0.659
4
UniProt:P21359 NF1
20
NF1 R816* [cytosol]
(R-HSA-6802424)
NF1 F1464L [cytosol]
(R-HSA-6802410)
NF1 K1444E [cytosol]
(R-HSA-6802414)
NF1 L1187I [cytosol]
(R-HSA-6802417)
NF1 R1276P [cytosol]
(R-HSA-6802420)
NF1 R1412S [cytosol]
(R-HSA-6802421)
NF1 R2517* [cytosol]
(R-HSA-9647532)
NF1 Q616Gfs*4 [cytosol]
(R-HSA-9647468)
NF1 R2450* [cytosol]
(R-HSA-9647535)
NF1 R2637* [cytosol]
(R-HSA-9647529)
NF1 R2637Q [cytosol]
(R-HSA-9647525)
NF1 R304* [cytosol]
(R-HSA-9647522)
NF1 R1276* [cytosol]
(R-HSA-9647550)
NF1 C845Vfs*33 [cytosol]
(R-HSA-9647486)
NF1 E133Nfs*32 [cytosol]
(R-HSA-9647480)
NF1 R1276Q [cytosol]
(R-HSA-9647545)
NF1 R1276L [cytosol]
(R-HSA-9647547)
NF1 C324* [cytosol]
(R-HSA-9647483)
NF1 A131Vfs*19 [cytosol]
(R-HSA-9647476)
NF1 R1534* [cytosol]
(R-HSA-9647542)
0.604
3
UniProt:P42337 Pik3ca
1
Pik3ca [cytosol]
(R-MMU-9027214)
0.589
3
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.581
9
UniProt:P11233 RALA
2
RALA [cytosol]
(R-HSA-170988)
GGC-RALA [cytoplasmic vesicle membrane]
(R-HSA-1458479)
0.571
2
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.571
2
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.556
3
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.556
3
UniProt:O95674 CDS2
1
CDS2 [mitochondrial inner membrane]
(R-HSA-1498755)
0.556
3
UniProt:Q8N5V2 NGEF
2
NGEF [cytosol]
(R-HSA-3006800)
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [cytosol]
(R-HSA-3006405)
ITGB3BP [nucleoplasm]
(R-HSA-606325)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
0.556
3
UniProt:Q9EQZ6
1
RAPGEF4 [plasma membrane]
(R-MMU-3008666)
0.556
3
UniProt:A0AVK6 E2F8
1
E2F8 [nucleoplasm]
(R-HSA-8952990)
0.556
3
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.556
3
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.556
3
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.556
3
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
3
UniProt:Q7Z569 BRAP
2
ub-BRAP [cytosol]
(R-HSA-5674001)
BRAP [cytosol]
(R-HSA-5672938)
0.524
3
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.508
2
UniProt:Q16850 CYP51A1
1
CYP51A1 [endoplasmic reticulum membrane]
(R-HSA-194721)
0.483
2
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.462
2
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