Reactome | S-Farn-proHRAS [endoplasmic reticulum membrane]

S-Farn-proHRAS [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9647918

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Ras, p21/H-RAS-1 , Transforming protein p21/H-Ras-1, c-H-ras

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01112 HRAS

Gene Names

HRAS, HRAS1

Chain

initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189

Reference Genes

BioGPS Gene:3265 HRAS

COSMIC (genes):HRAS HRAS

CTD Gene:3265 HRAS

dbSNP Gene:3265 HRAS

ENSEMBL:ENSG00000174775 HRAS

ENSEMBL:ENSG00000174775.18 HRAS

ENSEMBL:ENSG00000276536.4 HRAS

HGNC:5173 HRAS

KEGG Gene (Homo sapiens):3265 HRAS

Monarch:3265 HRAS

NCBI Gene:3265 HRAS

OMIM:190020 HRAS

UCSC:P01112 HRAS

Reference Transcript

Other Identifiers

0002640458

0006900092

11733320_a_at

11744709_a_at

1590_s_at

16733952

212983_PM_at

212983_at

3265

3358091

3358092

3358093

3358094

3358096

3358097

3358098

3358099

3358100

3358103

35701_at

7945436

A_23_P98183

GE57461

GO:0000139

GO:0000165

GO:0000166

GO:0001934

GO:0002376

GO:0003674

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006886

GO:0006897

GO:0006935

GO:0007010

GO:0007165

GO:0007166

GO:0007264

GO:0007265

GO:0007568

GO:0008022

GO:0008150

GO:0008284

GO:0008285

GO:0009887

GO:0010628

GO:0010629

GO:0010863

GO:0012501

GO:0016020

GO:0016192

GO:0016787

GO:0019003

GO:0023052

GO:0030335

GO:0032729

GO:0032991

GO:0034260

GO:0036211

GO:0042060

GO:0042088

GO:0042127

GO:0042832

GO:0043167

GO:0043226

GO:0043405

GO:0043406

GO:0043410

GO:0043524

GO:0043547

GO:0045944

GO:0046330

GO:0048144

GO:0048146

GO:0048169

GO:0048471

GO:0048856

GO:0048870

GO:0050679

GO:0050852

GO:0051402

GO:0051726

GO:0060612

GO:0070374

GO:0071480

GO:0090303

GO:0090314

GO:0090398

GO:0097193

GO:0098542

GO:0098696

GO:0098978

GO:1900029

GO:1905360

GO:2000251

GO:2000630

HMNXSV003016066

Hs.37003.0.S1_3p_at

Hs.37003.0.S1_3p_x_at

ILMN_1699798

ILMN_1773751

J00277_at

PH_hs_0031161

TC11001236.hg

V00574_s_at

Participates

as a member of

S-Farn-proRAS [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

HRAS Q61R [plasma membrane]

HRAS Q61L [plasma membrane]

HRAS Q61K [plasma membrane]

HRAS G13R [plasma membrane]

HRAS G12V [plasma membrane]

HRAS G12S [plasma membrane]

HRAS T58I [plasma membrane]

HRAS G13C [plasma membrane]

HRAS K117R [plasma membrane]

HRAS G13V [plasma membrane]

HRAS G13D [plasma membrane]

HRAS G13S [plasma membrane]

HRAS K117N [plasma membrane]

HRAS G12D [plasma membrane]

HRAS G12C [plasma membrane]

S-Farn-Me HRAS [plasma membrane]

HRAS [plasma membrane]

S-Farn-Me PalmS HRAS [Golgi membrane]

S-Farn-Me HRAS [endoplasmic reticulum membrane]

S-Farn-HRAS [endoplasmic reticulum membrane]

proHRAS [cytosol]

S-Farn-Me-2xPalmS HRAS [plasma membrane]

Inferred To

S-Farn-proNRAS [endoplasmic reticulum membrane] (Caenorhabditis elegans)

S-Farn-proNRAS [endoplasmic reticulum membrane] (Dictyostelium discoideum)

S-Farn-proNRAS [endoplasmic reticulum membrane] (Drosophila melanogaster)

hras [endoplasmic reticulum membrane] (Xenopus tropicalis)

hrasl [endoplasmic reticulum membrane] (Danio rerio)

S-Farn-proHRAS [endoplasmic reticulum membrane] (Canis familiaris)

S-Farn-proHRAS [endoplasmic reticulum membrane] (Gallus gallus)

S-Farn-proHRAS [endoplasmic reticulum membrane] (Mus musculus)

S-Farn-proHRAS [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of S-Farn-proHRAS [endoplasmic reticulum membrane] (Dictyostelium discoideum)

HRAS [endoplasmic reticulum membrane] (Bos taurus)

HRAS [endoplasmic reticulum membrane] (Sus scrofa)

Modified Residues

Name

S-farnesyl-L-cysteine (farnesyl group) at 186

Coordinate

186

Modification

farnesyl group

PsiMod Name

S-farnesyl-L-cysteine [MOD:00111]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.

Cross References

RefSeq

NP_005334.1, NP_789765.1, NP_001304983.1, NP_001123914.1

Guide to Pharmacology - Targets

2822

OpenTargets

ENSG00000174775

ZINC - Substances

RASH_HUMAN

ZINC target

P01112

PRO

P01112

PDB

4L9S, 1PLL, 7OG9, 1Q21, 1CRR, 3LBI, 3RS3, 6V9O, 1P2T, 4Q21, 5WDO, 4G3X, 3RSL, 1AGP, 4DLW, 1ZW6, 1XD2, 2RGA, 5WFR, 6CUR, 2X1V, 4G0N, 5E95, 3LO5, 1NVU, 6BVL, 1JAH, 2CL7, 3TGP, 1LF0, 6D59, 6D5L, 7JHP, 4DLY, 4US1, 3KKM, 2RGD, 4URY, 4DSU, 6ZL3, 1NVX, 3OIU, 6V9L, 7OGC, 3RS7, 1XJ0, 821P, 2VH5, 7DPH, 2C5L, 1P2S, 6D5W, 521P, 6BVJ, 121P, 3LBN, 1HE8, 7OGA, 6AXG, 3K9L, 3RS0, 6D5H, 7JIF, 2RGB, 2N42, 6BVM, 2LWI, 2CLC, 4DLR, 6V9F, 3RS4, 7L0F, 5WFP, 4XVR, 1JAI, 1WQ1, 5B2Z, 3L8Y, 6E6P, 1CTQ, 1NVV, 6D5M, 6NTC, 2CL0, 3KKN, 4URZ, 6V9M, 2LCF, 1P2U, 4DLT, 621P, 1IAQ, 4EFL, 4URW, 4NYI, 3KUD, 7OGF, 6DZH, 6CUO, 5B30, 3RS2, 1QRA, 5WDP, 3K9N, 3RRY, 4NYJ, 6D55, 1IOZ, 2QUZ, 1GNP, 6V9J, 7JIG, 6D5E, 4L9W, 3DDC, 1CRP, 6CUP, 7L0G, 6BVK, 5WFQ, 6AMB, 721P, 2RGE, 3OIV, 4US2, 2CE2, 2N46, 1XCM, 6NTD, 3LBH, 1LF5, 1P2V, 2Q21, 421P, 1BKD, 6D5J, 5VBE, 2UZI, 7OGD, 4DST, 4URX, 4DLU, 2CL6, 4DLZ, 7DPJ, 1PLJ, 4DLS, 6Q21, 3RS5, 4URU, 4RSG, 1K8R, 1GNR, 5P21, 6ZJ0, 2CLD, 4K81, 1ZVQ, 5VBZ, 5WFO, 3K8Y, 6BVI, 6V9N, 4XVQ, 4DLV, 6V94, 4EFN, 3RRZ, 4NYM, 7OGB, 221P, 1GNQ, 5X9S, 6D5G, 6MQT, 1AA9, 3L8Z, 7JII, 4DLX, 1RVD, 5WDQ, 1NVW, 2RGG, 1CLU, 3RSO, 3OIW, 6D56, 5ZC6, 2RGC, 2EVW, 6E6C, 4US0, 1LFD, 4EFM, 3I3S, 7OGE, 1PLK, 1CRQ, 7JIH, 6D5V, 4URV, 5WPL

ZINC - Investigational

RASH_HUMAN

IntEnz

3.6.5.2

GeneCards

P01112

HPA

ENSG00000174775-HRAS

Ensembl

ENST00000634098, ENSP00000488296, ENSG00000174775, ENST00000610977, ENST00000311189, ENSP00000480686, ENSP00000388246, ENSP00000480317, ENSP00000309845, ENSP00000488757, ENST00000631967, ENST00000631404, ENSP00000407586, ENST00000616241, ENST00000397596, ENSP00000482366, ENST00000615062, ENST00000451590, ENST00000417302, ENSG00000276536, ENSP00000488225, ENSP00000434023, ENSP00000380723, ENST00000493230

Pharos - Targets

P01112

Orphanet

16221

ZINC - Predictions - Purchasable

RASH_HUMAN

HMDB Protein

HMDBP01958

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134)	0.977	28
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.938	11
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.831	6
UniProt:Q12967 RALGDS	1	RALGDS [cytosol] (R-HSA-171001)	0.683	3
UniProt:Q9NZL6 RGL1	1	RGL1 [cytosol] (R-HSA-561160)	0.667	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.659	4
UniProt:P21359 NF1	20	NF1 R816* [cytosol] (R-HSA-6802424) NF1 F1464L [cytosol] (R-HSA-6802410) NF1 K1444E [cytosol] (R-HSA-6802414) NF1 L1187I [cytosol] (R-HSA-6802417) NF1 R1276P [cytosol] (R-HSA-6802420) NF1 R1412S [cytosol] (R-HSA-6802421) NF1 R2517* [cytosol] (R-HSA-9647532) NF1 Q616G fs4 [cytosol] (R-HSA-9647468) NF1 R2450 [cytosol] (R-HSA-9647535) NF1 R2637* [cytosol] (R-HSA-9647529) NF1 R2637Q [cytosol] (R-HSA-9647525) NF1 R304* [cytosol] (R-HSA-9647522) NF1 R1276* [cytosol] (R-HSA-9647550) NF1 C845V fs33 [cytosol] (R-HSA-9647486) NF1 A132L fs33 [cytosol] (R-HSA-9647480) NF1 R1276Q [cytosol] (R-HSA-9647545) NF1 R1276L [cytosol] (R-HSA-9647547) NF1 C324* [cytosol] (R-HSA-9647483) NF1 A131G fs18 [cytosol] (R-HSA-9647476) NF1 R1534 [cytosol] (R-HSA-9647542)	0.604	3
UniProt:P42337 Pik3ca	1	Pik3ca [cytosol] (R-MMU-9027214)	0.589	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.581	9
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y416-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.571	2
UniProt:P11233 RALA	2	RALA [cytosol] (R-HSA-170988) GGC-RALA [cytoplasmic vesicle membrane] (R-HSA-1458479)	0.571	2
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) Active NIK [cytosol] (R-HSA-5607646) K48polyUb-NIK [cytosol] (R-HSA-5668525)	0.556	3
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.556	3
UniProt:Q9EQZ6	1	RAPGEF4 [plasma membrane] (R-MMU-3008666)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.556	3
UniProt:Q8N5V2 NGEF	2	p-Y179-NGEF [cytosol] (R-HSA-3928441) NGEF [cytosol] (R-HSA-3006800)	0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.524	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.508	2
UniProt:Q16850 CYP51A1	1	CYP51A1 [endoplasmic reticulum membrane] (R-HSA-194721)	0.483	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.462	2

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