Reactome | S-Farn-proHRAS [endoplasmic reticulum membrane]

S-Farn-proHRAS [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9647918

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Ras, p21/H-RAS-1 , Transforming protein p21/H-Ras-1, c-H-ras

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01112 HRAS

Gene Names

HRAS, HRAS1

Chain

initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189

Reference Genes

BioGPS Gene:3265 HRAS

COSMIC (genes):HRAS HRAS

CTD Gene:3265 HRAS

dbSNP Gene:3265 HRAS

ENSEMBL:ENSG00000174775 HRAS

ENSEMBL:ENSG00000276536 HRAS

HGNC:5173 HRAS

KEGG Gene (Homo sapiens):3265 HRAS

Monarch:3265 HRAS

NCBI Gene:3265 HRAS

OMIM:190020 HRAS

UCSC:P01112 HRAS

Reference Transcript

Other Identifiers

0002640458

0006900092

11733320_a_at

11744709_a_at

1590_s_at

16733952

212983_at

3265

3358091

3358092

3358093

3358094

3358096

3358097

3358098

3358099

3358100

3358103

35701_at

7945436

A_23_P98183

GE57461

GO:0000139

GO:0000165

GO:0000166

GO:0000278

GO:0001889

GO:0001934

GO:0002223

GO:0002376

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006464

GO:0006605

GO:0006810

GO:0006897

GO:0006915

GO:0006935

GO:0006950

GO:0007010

GO:0007049

GO:0007050

GO:0007093

GO:0007165

GO:0007166

GO:0007264

GO:0007265

GO:0007267

GO:0007568

GO:0007569

GO:0008022

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009058

GO:0009887

GO:0010628

GO:0010629

GO:0010863

GO:0015031

GO:0016020

GO:0016192

GO:0019003

GO:0022607

GO:0030335

GO:0032729

GO:0034260

GO:0034641

GO:0035900

GO:0040011

GO:0042088

GO:0042832

GO:0043167

GO:0043226

GO:0043231

GO:0043406

GO:0043410

GO:0043524

GO:0043547

GO:0044877

GO:0045740

GO:0045944

GO:0046330

GO:0046579

GO:0048013

GO:0048169

GO:0048471

GO:0048856

GO:0048870

GO:0050679

GO:0050852

GO:0070374

GO:0071480

GO:0090303

GO:0090314

GO:0090398

GO:0097193

GO:0098696

GO:0098978

GO:1900029

GO:2000251

GO:2000630

Hs.37003.0.S1_3p_at

Hs.37003.0.S1_3p_x_at

ILMN_1699798

ILMN_1773751

J00277_at

PH_hs_0031161

TC11001236.hg

V00574_s_at

Participant Of

hasMember

S-Farn-proRAS [endoplasmic reticulum membrane]

Other forms of this molecule

HRAS Q61R [plasma membrane]

HRAS Q61L [plasma membrane]

HRAS Q61K [plasma membrane]

HRAS G13R [plasma membrane]

HRAS G12V [plasma membrane]

HRAS G12S [plasma membrane]

HRAS T58I [plasma membrane]

HRAS G13C [plasma membrane]

HRAS K117R [plasma membrane]

HRAS G13V [plasma membrane]

HRAS G13D [plasma membrane]

HRAS G13S [plasma membrane]

HRAS K117N [plasma membrane]

HRAS G12D [plasma membrane]

HRAS G12C [plasma membrane]

HRAS [plasma membrane]

S-Farn-Me PalmS HRAS [Golgi membrane]

S-Farn-Me HRAS [plasma membrane]

proHRAS [cytosol]

S-Farn-Me HRAS [endoplasmic reticulum membrane]

S-Farn-HRAS [endoplasmic reticulum membrane]

S-Farn-Me-2xPalmS HRAS [plasma membrane]

Inferred To

Ras85D [endoplasmic reticulum membrane] (Drosophila melanogaster)

hras [endoplasmic reticulum membrane] (Xenopus tropicalis)

Hras [endoplasmic reticulum membrane] (Mus musculus)

Hras [endoplasmic reticulum membrane] (Rattus norvegicus)

hrasb [endoplasmic reticulum membrane] (Danio rerio)

S-Farn-proHRAS [endoplasmic reticulum membrane] (Bos taurus)

HRAS [endoplasmic reticulum membrane] (Canis familiaris)

HRAS [endoplasmic reticulum membrane] (Gallus gallus)

HRAS [endoplasmic reticulum membrane] (Sus scrofa)

let-60 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Modified Residues

Name

S-farnesyl-L-cysteine (farnesyl group) at 186

Coordinate

186

Modification

farnesyl group

PsiMod Name

S-farnesyl-L-cysteine [MOD:00111]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.

Cross References

RefSeq

NP_001123914.1, NP_005334.1, NP_001304983.1, NP_789765.1

OpenTargets

ENSG00000174775

ZINC - Substances

RASH_HUMAN

ZINC target

P01112

PRO

P01112

PDB

1XJ0, 1ZW6, 5VBE, 6D5J, 2UZI, 1LFD, 4URW, 1AA9, 1IOZ, 5B2Z, 4XVR, 4DLR, 1NVU, 4URV, 6AXG, 1CTQ, 2GDP, 6BVI, 2RGG, 3OIW, 2C5L, 3OIV, 5WDQ, 1GNP, 2LCF, 2RGD, 4US2, 3RSO, 1PLK, 6BVJ, 3LBI, 4DLW, 1HE8, 2CLC, 4Q21, 4DLV, 6CUP, 4DSU, 3RSL, 3K9L, 3KKM, 1PLL, 6D5W, 1NVW, 4EFL, 1P2S, 3RRY, 6CUR, 1JAI, 4DLT, 3RS7, 3DDC, 2CE2, 3KUD, 2Q21, 621P, 1NVX, 221P, 2RGB, 1RVD, 1CRR, 3RS5, 4DLY, 2QUZ, 4RSG, 3L8Z, 121P, 3K8Y, 6D59, 6D5M, 2CL6, 1Q21, 5WFO, 4XVQ, 2N42, 4K81, 5WDP, 1CLU, 1BKD, 4NYJ, 4EFN, 3RS2, 6AMB, 3RS0, 2RGC, 5WFQ, 6D5E, 1GNQ, 4URZ, 4US0, 1K8R, 5WFR, 6BVM, 6D5H, 4URX, 6D55, 3I3S, 5E95, 1P2T, 4L9W, 1ZVQ, 3TGP, 1PLJ, 5B30, 5ZC6, 4URU, 5P21, 821P, 2CLD, 1CRP, 4DLX, 1P2V, 2EVW, 1NVV, 1LF5, 3LBH, 6BVK, 1XCM, 1JAH, 1AGP, 3OIU, 2RGE, 6CUO, 5WPL, 4DST, 6D5V, 4DLU, 721P, 4NYI, 2VH5, 4EFM, 1QRA, 1GNR, 4DLS, 4DLZ, 6D56, 2N46, 2X1V, 1WQ1, 521P, 6D5L, 4G0N, 1P2U, 3LO5, 1IAQ, 1LF0, 3LBN, 3RS4, 6E6C, 1XD2, 2RGA, 2LWI, 3RS3, 3L8Y, 3K9N, 4L9S, 3KKN, 4NYM, 2CL0, 3RRZ, 6Q21, 5WDO, 5VBZ, 5WFP, 4G3X, 2CL7, 1CRQ, 4US1, 421P, 6E6P, 6D5G, 6DZH, 6BVL, 4URY, 5X9S

ZINC - Investigational

RASH_HUMAN

HPA

ENSG00000174775-HRAS

GeneCards

P01112

Ensembl

ENST00000397594, ENST00000631404, ENST00000631967, ENST00000397596, ENSP00000480317, ENSP00000434023, ENSP00000309845, ENST00000451590, ENST00000493230, ENST00000311189, ENST00000610977, ENSP00000407586, ENSP00000388246, ENST00000615062, ENSG00000276536, ENSP00000488757, ENSP00000380723, ENSP00000380722, ENSP00000488296, ENST00000634098, ENSG00000174775, ENSP00000482366, ENST00000616241, ENSP00000480686, ENSP00000488225, ENST00000417302

Orphanet

16221

ZINC - Predictions - Purchasable

RASH_HUMAN

HMDB Protein

HMDBP01958

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.975	25
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.938	11
UniProt:P15056 BRAF	68	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.783	5
UniProt:Q12967 RALGDS	1	RALGDS [cytosol] (R-HSA-171001)	0.704	3
UniProt:Q9NZL6 RGL1	1	RGL1 [cytosol] (R-HSA-561160)	0.667	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.602	9
UniProt:P42337 Pik3ca	1	Pik3ca [cytosol] (R-MMU-9027214)	0.589	3
UniProt:Q9EQZ6	1	Rapgef4 [plasma membrane] (R-MMU-3008666)	0.556	3
UniProt:Q7Z569 BRAP	2	BRAP [cytosol] (R-HSA-5672938) ub-BRAP [cytosol] (R-HSA-5674001)	0.524	3
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [Golgi membrane] (R-HSA-204504)	0.508	2
UniProt:P21359 NF1	37	NF1 F1464L [cytosol] (R-HSA-6802410) NF1 R816* [cytosol] (R-HSA-6802424) NF1 K1444E [cytosol] (R-HSA-6802414) NF1 L1187I [cytosol] (R-HSA-6802417) NF1 R1276P [cytosol] (R-HSA-6802420) NF1 R1412S [cytosol] (R-HSA-6802421) NF1 R2517* [cytosol] (R-HSA-9647532) NF1 Q616G fs4 [cytosol] (R-HSA-9647468) NF1 R2450 [cytosol] (R-HSA-9647535) NF1 R2637* [cytosol] (R-HSA-9647529) NF1 R2637Q [cytosol] (R-HSA-9647525) NF1 R304* [cytosol] (R-HSA-9647522) NF1 R1276* [cytosol] (R-HSA-9647550) NF1 C845V fs33 [cytosol] (R-HSA-9647486) NF1 A132L fs33 [cytosol] (R-HSA-9647480) NF1 R1276Q [cytosol] (R-HSA-9647545) NF1 R1276L [cytosol] (R-HSA-9647547) NF1 C324* [cytosol] (R-HSA-9647483) NF1 A131G fs18 [cytosol] (R-HSA-9647476) NF1 R1534 [cytosol] (R-HSA-9647542) NF1 R1241* [cytosol] (R-HSA-9647473) NF1 R1534Q [cytosol] (R-HSA-9647539) NF1 S1053* [cytosol] (R-HSA-9647502) NF1 E163D fs2 [cytosol] (R-HSA-9656584) NF1 S980 [cytosol] (R-HSA-9647499) NF1 I1009F fs3 [cytosol] (R-HSA-9647492) NF1 Y489C [cytosol] (R-HSA-9647494) NF1 E113D fs61 [cytosol] (R-HSA-9647489) NF1 R416* [cytosol] (R-HSA-9647516) NF1 R304Q [cytosol] (R-HSA-9647519) NF1 R416Q [cytosol] (R-HSA-9647513) NF1 G849E fs29 [cytosol] (R-HSA-9656596) NF1(2-2839) [cytosol] (R-HSA-947770) ub-NF1(2-2839) [cytosol] (R-HSA-5658418) NF1 R69N fs7 [cytosol] (R-HSA-9647505) NF1 R440* [cytosol] (R-HSA-9647511) NF1 R440Q [cytosol] (R-HSA-9647508)	0.499	2

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