Reactome | NMU [extracellular region]

NMU [extracellular region]

Stable Identifier

R-HSA-964817

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuromedin-U-25, NMU_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q6UXL0 IL20RB

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External Reference Information

External Reference

UniProt:P48645 NMU

Gene Names

NMU

Chain

signal peptide:1-34, propeptide:35-103, peptide:104-139, peptide:104-136, peptide:142-166, propeptide:170-174

Reference Genes

BioGPS Gene:10874 NMU

COSMIC (genes):NMU NMU

CTD Gene:10874 NMU

dbSNP Gene:10874 NMU

ENSEMBL:ENSG00000109255 NMU

ENSEMBL_homo_sapiens_GENE:ENSG00000109255.11 NMU

HGNC:7859 NMU

KEGG Gene (Homo sapiens):10874 NMU

Monarch:10874 NMU

NCBI Gene:10874 NMU

OMIM:605103 NMU

UCSC:P48645 NMU

Reference Transcript

Other Identifiers

10874

11728376_s_at

11728377_x_at

16976117

206023_PM_at

206023_at

2770040

2770041

2770043

2770044

2770045

2770046

2770048

2770050

2770051

2770052

2770053

33483_at

8100464

A_23_P69537

GO:0001659

GO:0003012

GO:0005102

GO:0005515

GO:0005576

GO:0006940

GO:0007186

GO:0007218

GO:0023052

GO:0031839

GO:0031840

GO:0042922

GO:0043195

GO:0045987

GO:0050806

GO:0060259

GO:0097009

GO:2000821

HMNXSV003044992

ILMN_2162253

TC04001216.hg

X76029_at

g5729946_3p_at

Participates

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as an input of

Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)

as a component of

NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)

Inferred To

Nmu [extracellular region] (Mus musculus)

Nmu [extracellular region] (Rattus norvegicus)

NMU [extracellular region] (Bos taurus)

NMU [extracellular region] (Canis familiaris)

NMU [extracellular region] (Gallus gallus)

NMU [extracellular region] (Sus scrofa)

nmu [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_006672.1, NP_001278974.1, NP_001278975.1

OpenTargets

ENSG00000109255

GeneCards

P48645

HPA

ENSG00000109255-NMU

Ensembl

ENSG00000109255, ENSP00000264218, ENST00000264218

PRO

P48645

Pharos - Targets

P48645

PDB

7XK8, 7W53, 7W55

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.718	6
UniProt:P23219 PTGS1	2	O-acetyl-L-serine-PTGS1 [endoplasmic reticulum membrane] (R-HSA-2314694) PTGS1 [endoplasmic reticulum membrane] (R-HSA-428931)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9UHG0 DCDC2			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q9BYP8 KRTAP17-1	1	KRTAP17-1 [cytosol] (R-HSA-6809980)	0.556	5
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q9BYS1 KRTAP1-5	1	KRTAP1-5 [cytosol] (R-HSA-6809867)	0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:P60371 KRTAP10-6	1	KRTAP10-6 [cytosol] (R-HSA-6810247)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q8N6Y1 PCD20			0.527	3
UniProt:Q9NU53 GINM1			0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:Q9UBM8 MGAT4C	1	MGAT4C [Golgi membrane] (R-HSA-975907)	0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586)	0.527	3
UniProt:O75752 B3GALNT1	1	B3GALNT1 [Golgi membrane] (R-HSA-8878918)	0.527	2
UniProt:Q6UXL0 IL20RB	1	IL20RB [plasma membrane] (R-HSA-448709)	0.527	3

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