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p-T-EIF2AK1:ferriheme dimer autophosphorylates
Stable Identifier
R-HSA-9648883
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)
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During heme deficiency, EIF2AK1 (HRI) autophosphorylates, notably on threonine residues in the activation loop (inferred from the mouse homolog). EIF2AK1 also has many phosphorylated residues prior to activation in response to heme deficiency (inferred from the mouse homolog). Autophosphorylation of threonine-488 (threonine-485 in the mouse homolog) is essential for kinase activity of EIF2AK1 acting on EIF2S1 (eIF2-alpha) in response to heme deficiency and oxidative stress by arsenite (inferred from the mouse homolog).
Participants
Input
x 4
ATP [cytosol]
p-T-EIF2AK1:ferriheme dimer [cytosol]
(Homo sapiens)
Output
x 4
ADP [cytosol]
p-T,T486,T488-EIF2AK1:ferriheme dimer [cytosol]
(Homo sapiens)
Participates
as an event of
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Catalyst Activity
protein serine/threonine kinase activity of p-T-EIF2AK1:ferriheme dimer [cytosol]
Physical Entity
p-T-EIF2AK1:ferriheme dimer [cytosol]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
p-T-Eif2ak1:ferriheme dimer autophosphorylates (Mus musculus)
Authored
May, B (2019-06-10)
Reviewed
Chen, JJ (2019-10-22)
Created
May, B (2019-06-10)
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