KRAS G12A [plasma membrane]

Stable Identifier
R-HSA-9649088
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
29199977 Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras

Xu, S, Long, BN, Boris, GH, Chen, A, Ni, S, Kennedy, MA

Acta Crystallogr D Struct Biol 2017
26662311 G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab

Fiala, O, Buchler, T, Mohelnikova-Duchonova, B, Melichar, B, Matejka, VM, Holubec, L, Kulhankova, J, Bortlicek, Z, Bartouskova, M, Liska, V, Topolcan, O, Sedivcova, M, Finek, J

Tumour Biol. 2016
30738221 Efficacy of Immune Checkpoint Inhibitors in KRAS-Mutant Non-Small Cell Lung Cancer (NSCLC)

Jeanson, A, Tomasini, P, Souquet-Bressand, M, Brandone, N, Boucekine, M, Grangeon, M, Chaleat, S, Khobta, N, Milia, J, Mhanna, L, Greillier, L, Biemar, J, Nanni, I, Ouafik, L, Garcia, S, Mazieres, J, Barlesi, F, Mascaux, C

J Thorac Oncol 2019
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703 KRAS
HGNC:6407 KRAS
KEGG Gene (Homo sapiens):3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
Other Identifiers
0006110070
0007040129
11717962_x_at
11717963_a_at
11717964_a_at
11717965_s_at
16762399
1940_at
204009_s_at
204010_s_at
214352_s_at
231640_at
32159_at
3447860
3447862
3447864
3447865
3447866
3447867
3447868
3447869
3447870
3447871
3447872
3447873
3447874
3447879
3447880
3447884
3447886
3845
3958621
7961865
A_23_P306500
A_23_P306507
A_23_P45140
A_33_P3317815
GE61031
GO:0000003
GO:0000165
GO:0000166
GO:0001889
GO:0001934
GO:0002223
GO:0002376
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005925
GO:0006464
GO:0006950
GO:0007010
GO:0007165
GO:0007265
GO:0007267
GO:0007565
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008542
GO:0009058
GO:0010628
GO:0016020
GO:0016787
GO:0019002
GO:0019003
GO:0019221
GO:0021897
GO:0030036
GO:0030154
GO:0030275
GO:0031234
GO:0031647
GO:0032228
GO:0034641
GO:0035022
GO:0035900
GO:0038002
GO:0042592
GO:0042802
GO:0043167
GO:0043226
GO:0043406
GO:0043524
GO:0044877
GO:0045121
GO:0045596
GO:0048169
GO:0048856
GO:0048873
GO:0050877
GO:0051000
GO:0051092
GO:0051146
GO:0051384
GO:0051385
GO:0060441
GO:2000774
HMNXSV003005517
HMNXSV003016084
Hs.184050.0.S1_3p_a_at
Hs.184050.1.A1_3p_a_at
Hs.184050.4.A1_3p_at
ILMN_1652104
ILMN_1728071
M54968_at
PH_hs_0028364
PH_hs_0030345
TC12001314.hg
g4826811_3p_a_at
Participates
as a member of
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS A146T [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS G12C [plasma membrane]
KRAS L19F [plasma membrane]
KRAS G12D [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS V14I [plasma membrane]
KRAS G12V [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G13D [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G60R [plasma membrane]
KRAS D33E [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS G60V [plasma membrane]
KRAS G60D [plasma membrane]
KRAS E63K [plasma membrane]
KRAS A59T [plasma membrane]
proKRAS [cytosol]
S-Farn-proKRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
KRAS [plasma membrane]
Modified Residues
Name
glycine 12 replaced with L-alanine
Coordinate
12
PsiMod
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
L-alanine residue [MOD:00010]
A protein modification that effectively converts a source amino acid residue to an L-alanine.
Disease
Name Identifier Synonyms
lung cancer DOID:1324
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
colorectal cancer DOID:9256
pancreatic cancer DOID:1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
Cross References
RefSeq
COSMIC
OpenTargets
HPA
GeneCards
ZINC - Substances
ZINC target
Ensembl
PRO
Orphanet
PDB
5W22, 4M1Y, 1N4S, 5V9L, 5UFQ, 5VPZ, 5WHD, 4PZZ, 4LYF, 6FA1, 1D8D, 5KYK, 4TQ9, 5WHB, 6CCX, 6UT0, 6CCH, 5WPM, 5V6V, 1N4Q, 6O53, 6W4E, 6PGP, 6BP1, 6MBU, 6GJ6, 6GQT, 5UK9, 6BOF, 6OB2, 6H47, 3GFT, 4EPW, 6EPP, 6EPM, 6O4Z, 5O2T, 4PZY, 6GQY, 6P8Z, 6GOE, 4M1O, 5OCG, 6YR8, 6QUU, 4LYH, 5VQ2, 5WLB, 1N4P, 6P8W, 6CC9, 4M1W, 6GJ7, 6USX, 4M22, 6GQW, 4DSN, 6EPO, 6MBQ, 4EPX, 6MNX, 6EPL, 6O51, 4M1T, 4QL3, 5VQ0, 6F76, 6GOF, 4Q02, 5VPI, 1D8E, 4NMM, 4LYJ, 6V65, 6T5V, 6N2J, 4EPR, 5V6S, 4Q03, 5US4, 4M1S, 6FA4, 6JTO, 6T5U, 6N2K, 6H46, 4LV6, 6JTN, 6EPN, 4EPV, 5V71, 4LRW, 4EPY, 6QUX, 6GOD, 6PGO, 6FA3, 6GQX, 6MBT, 1KZO, 5OCT, 4Q01, 4DSO, 6ASA, 6GOG, 5VPY, 6CU6, 4EPT, 6M9W, 6OIM, 5VQ1, 5YY1, 6V5L, 6PQ3, 5VP7, 5V9U, 6ASE, 6B0V, 4M21, 6FA2, 5VBM, 6WGN, 6MQN, 4OBE, 1N4R, 6ARK, 6O4Y, 4LUC, 6PTS, 6E6G, 6MTA, 6TAN, 5YXZ, 6YXW, 5VQ6, 5UFE, 5F2E, 5WHA, 6O46, 4LPK, 4L8G, 6MS9, 6T5B, 5OCO, 6USZ, 6TAM, 6GOM, 6O36, 6W4F, 6V6F, 6ZLI, 6MQG, 6E6F, 6QUW, 6P8X, 1KZP, 5O2S, 4LDJ, 5TAR, 5VQ8, 4WA7, 4TQA, 6JTP, 6P0Z, 6QUV, 5UQW, 5V9O, 6P8Y, 5TB5, 6B0Y, 5USJ, 5MLA, 6GJ8, 5MLB, 5XCO, 6PTW, 6OB3, 5WHE, 6ZL5, 6GJ5
Interactors (4)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  54 0.623 5
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]  6 0.462 2
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