KRAS G13C [plasma membrane]

Stable Identifier
R-HSA-9649636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17504988 KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

Massarelli, E, Herbst, RS, Xavier, AC, Tang, X, Liu, DD, Ozburn, NC, Varella-Garcia, M, Bekele, BN, Wistuba, II

Clin. Cancer Res. 2007
18621636 Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone

Amado, RG, Radinsky, R, Sarosi, I, Hecht, JR, Berlin, J, Juan, T, Meropol, NJ, Freeman, DJ, Mitchell, E, Reiner, M

Clin Colorectal Cancer 2008
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703 KRAS
HGNC:6407 KRAS
KEGG:hsa:3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
Participates
as a candidate of
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS A146T [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS G12C [plasma membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
S-Farn-proKRAS [endoplasmic reticulum membrane]
proKRAS [cytosol]
KRAS [plasma membrane]
KRAS A59T [plasma membrane]
KRAS E63K [plasma membrane]
KRAS G60D [plasma membrane]
KRAS G60V [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS D33E [plasma membrane]
KRAS G60R [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G13D [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G12V [plasma membrane]
KRAS V14I [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS G12D [plasma membrane]
KRAS L19F [plasma membrane]
Modified Residues
Name
glycine 13 replaced with L-cysteine
Coordinate
13
PsiMod
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
Disease
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC target
PRO
PDB
6VC8, 6O4Y, 8FMK, 5MLB, 8I5E, 4Q02, 5US4, 8TXE, 4NMM, 8V39, 6OB2, 4LDJ, 6CU6, 1KZO, 8BLR, 6WS4, 7W5R, 6BP1, 6O36, 6ZLI, 6V5L, 8AQ5, 6PTW, 6CC9, 8TBJ, 4M1S, 9BHP, 7SCW, 4WA7, 6GQW, 5XCO, 5YY1, 3GFT, 7LGI, 7U8H, 8G9P, 8B69, 8DNI, 4EPT, 8G47, 7R0M, 5UFE, 4Q01, 5MLA, 5WHD, 8I5D, 6O51, 6MQG, 8F0M, 6EPL, 8ONV, 8T74, 6EPO, 5WLB, 6FA3, 5UK9, 8DGS, 7A47, 7LC2, 8JHL, 7RP2, 7ACH, 5V6V, 8STN, 4PZZ, 6GJ7, 8AFB, 5W22, 5VPY, 4LPK, 7RT1, 7C41, 6CCH, 6GQT, 6GOE, 8T4V, 1D8D, 4EPY, 8CPR, 6ZL5, 6M9W, 2MSE, 8I5C, 8CX5, 6XHB, 8BE4, 7NY8, 8UN4, 7TLK, 8TXG, 6W4E, 8G42, 8AZX, 8T73, 6E6F, 4LYJ, 8TXH, 4DSO, 6FA4, 8V3A, 6USZ, 4PZY, 6T5U, 8AQ7, 4Q03, 9BFY, 8STM, 5VQ2, 7A1Y, 5O2S, 8TBN, 1N4P, 6V65, 8VGQ, 5VPI, 6P8Z, 6B0V, 6QUW, 8TBM, 8G4H, 4EPR, 4EPX, 5OCG, 6JTN, 8VRA, 7F0W, 6MS9, 7EW9, 6WS2, 8UN3, 8EIE, 8BE3, 6O4Z, 8FMJ, 5TB5, 8VRB, 8T75, 8QU8, 9AX6, 8YIV, 6EPP, 8JJS, 8TY2, 6H46, 5VBM, 4LYH, 7ACQ, 6T5V, 8UN5, 7KMR, 5V9O, 6GJ8, 5VPZ, 6QUU, 8JGD, 7RT4, 9BHO, 8TBL, 7C40, 6E6G, 5VQ0, 7A1W, 6JTP, 8EER, 6P8X, 6XGU, 7RPZ, 8DNK, 8VJZ, 4M1W, 6ASA, 6JTO, 8FMI, 6XHA, 5WHE, 6O46, 4DSN, 8AZR, 8YJ2, 8RRO, 6W4F, 6FA1, 4L8G, 8EZG, 8TXK, 8ECR, 7KYZ, 4OBE, 8R7X, 7ACF, 6H47, 5V9L, 6GJ5, 6TAM, 6PTS, 8TBF, 6GOF, 5OCO, 5YXZ, 8AFD, 9BI2, 4M22, 7VVB, 6GQX, 5VQ1, 7RSC, 1N4Q, 6MBU, 7A1X, 7RT5, 8PIY, 4EPW, 6UT0, 8DNJ, 6XGV, 6ARK, 6N2J, 5V71, 8EBZ, 7R0Q, 8TY8, 6EPM, 8AZZ, 7YCC, 5WHB, 6CCX, 4LUC, 4LYF, 6O53, 5USJ, 5WPM, 8R7W, 5F2E, 6OIM, 8TVK, 6USX, 6TAN, 6OB3, 8T72, 8PI0, 5VQ8, 8QW7, 7Q9U, 4M1Y, 5VP7, 9BHQ, 4TQA, 6GQY, 8TBH, 7RT3, 8QUG, 1N4R, 7RSE, 5VQ6, 7OK4, 6P8Y, 5KYK, 5O2T, 2MSC, 6VJJ, 6PQ3, 5TAR, 7TLG, 8WUL, 6MQN, 8BE5, 7YUZ, 7LC1, 8B6I, 7EWB, 6MNX, 8AZY, 8T71, 7YV1, 5UQW, 8EPW, 8DGT, 6BOF, 8TXJ, 7MQU, 4QL3, 7RP4, 6GJ6, 7KFZ, 7LZ5, 6MTA, 5UFQ, 8B78, 9BG1, 6GOG, 8EDY, 4M21, 8QW6, 8G4F, 7T1F, 6P8W, 6MBQ, 8B00, 5OCT, 1N4S, 8G9Q, 7T47, 6QUX, 4M1T, 6YR8, 6PGO, 7EYX, 8TBK, 7ROV, 6B0Y, 7O70, 5WHA, 6YXW, 6ASE, 6N2K, 7EWA, 6EPN, 6FA2, 7STF, 6T5B, 5V6S, 7MDP, 6V6F, 8TY9, 7YCE, 7ACA, 7OO7, 6WGN, 1KZP, 8AZV, 7TLE, 6F76, 7RP3, 5V9U, 8UDR, 4LRW, 8AFC, 6MBT, 4TQ9, 8QVU, 1D8E, 7SCX, 8VR9, 8DVG, 7RT2, 9BI1, 8S8C, 6PGP, 6P0Z, 6GOD, 7OK3, 6QUV, 6GOM, 4M1O, 7R0N, 2MSD, 8WTE, 4EPV, 8X6R, 4LV6
COSMIC
GeneCards
HPA
Pharos - Targets
Orphanet
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:P15056 BRAF  20 0.68 5
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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