Reactome | MAP2K1 C121S [cytosol]

MAP2K1 C121S [cytosol]

Stable Identifier

R-HSA-9652013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MEK1, Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1), Dual specificity mitogen-activated protein kinase kinase 1 , MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by MAP2K mutants (Homo sapiens)
      - MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
        
        MAP2K1 and MAP2K2 mutants [cytosol] (Homo sapiens)
        
        MAP2K1 C121S dimer [cytosol] (Homo sapiens)
        
        MAP2K1 C121S [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21383288	Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling Wagle, N, Emery, C, Berger, MF, Davis, MJ, Sawyer, A, Pochanard, P, Kehoe, SM, Johannessen, CM, Macconaill, LE, Hahn, WC, Meyerson, M, Garraway, LA	J. Clin. Oncol.	2011

External Reference Information

External Reference

UniProt:Q02750 MAP2K1

Gene Names

MAP2K1, MEK1, PRKMK1

Chain

chain:1-393

Reference Genes

BioGPS Gene:5604 MAP2K1

COSMIC (genes):MAP2K1 MAP2K1

CTD Gene:5604 MAP2K1

dbSNP Gene:5604 MAP2K1

ENSEMBL:ENSG00000169032 MAP2K1

HGNC:6840 MAP2K1

KEGG Gene (Homo sapiens):5604 MAP2K1

Monarch:5604 MAP2K1

NCBI Gene:5604 MAP2K1

OMIM:176872 MAP2K1

UCSC:Q02750 MAP2K1

Reference Transcript

Other Identifiers

0001740347

1130_at

11717291_a_at

11749555_a_at

11757478_s_at

16802190

1844_s_at

202670_at

3092255

3092256

3092263

3092264

3598663

3598664

3598670

3598671

3598672

3598673

3598688

3598690

3598691

3598692

3598696

3598697

3598700

3598701

3598702

5604

7984319

A_23_P20248

GE57608

GO:0000003

GO:0000165

GO:0000166

GO:0000187

GO:0000278

GO:0000902

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004712

GO:0004713

GO:0005078

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005783

GO:0005794

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006935

GO:0006950

GO:0007049

GO:0007050

GO:0007165

GO:0007346

GO:0007507

GO:0007568

GO:0008022

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009790

GO:0010628

GO:0010629

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018107

GO:0018108

GO:0019899

GO:0021697

GO:0023014

GO:0030154

GO:0030182

GO:0030216

GO:0030234

GO:0030674

GO:0030878

GO:0031098

GO:0031410

GO:0032147

GO:0032872

GO:0034641

GO:0040011

GO:0043167

GO:0043226

GO:0043539

GO:0045597

GO:0045893

GO:0047485

GO:0048538

GO:0048646

GO:0048679

GO:0048856

GO:0048870

GO:0050772

GO:0060020

GO:0060324

GO:0060425

GO:0060440

GO:0060502

GO:0060674

GO:0060711

GO:0070371

GO:0070374

GO:0071902

GO:0090170

GO:0090398

GO:0097110

GO:1903800

GO:2000641

Hs.3446.0.A2_3p_at

ILMN_1694240

L05624_s_at

L11284_at

PH_hs_0022483

TC15000613.hg

Participant Of

hasComponent

MAP2K1 C121S dimer [cytosol]

Other forms of this molecule

MAP2K1(9-393) [cytosol]

MAP2K1(2-8) [cytosol]

MAP2K1 F53S [cytosol]

MAP2K1 D67N [cytosol]

MAP2K1 Q56P [cytosol]

MAP2K1 E203K [cytosol]

MAP2K1 V60E [cytosol]

MAP2K1 P124S [cytosol]

MAP2K1 Y130C [cytosol]

MAP2K1 G128V [cytosol]

MAP2K1 F53L [cytosol]

MAP2K1 K57N [cytosol]

MAP2K1 K57T [cytosol]

MAP2K1 F53V [cytosol]

MAP2K1 D67Y [cytosol]

MAP2K1 G128D [cytosol]

MAP2K1 P124L [cytosol]

MAP2K1 F53Y [cytosol]

MAP2K1 E44_E57del [cytosol]

MAP2K1 P124Q [cytosol]

MAP2K1 F53C [cytosol]

p-S,218, S222,T292 MAP2K1 [cytosol]

MAP2K1 [cytosol]

p-T286,T292-MAP2K1 [cytosol]

p-S218,S222,T286,T292-MAP2K1 [cytosol]

p-S218,S222-MAP2K1 [cytosol]

Modified Residues

Name

L-cysteine 121 replaced with L-serine

Coordinate

121

PsiMod

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

L-cysteine removal [MOD:01635]

A protein modification that effectively removes or replaces an L-cysteine.

Disease

Name	Identifier	Synonyms
hematologic cancer	2531	hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)

Cross References

RefSeq

NP_002746.1, XP_016877900.1

ZINC - World Drugs

MP2K1_HUMAN

OpenTargets

ENSG00000169032

ZINC - FDA approved

MP2K1_HUMAN

ZINC - Substances

MP2K1_HUMAN

ZINC - Biogenic

MP2K1_HUMAN

ZINC target

Q02750

PRO

Q02750

PDB

3V04, 4U7Z, 3EQG, 3WIG, 3OS3, 3VVH, 4U80, 5HZE, 2P55, 3EQB, 4AN3, 4ARK, 4LMN, 3ZLS, 3V01, 3ZM4, 3PP1, 3ORN, 6U2G, 6Q0T, 3ZLY, 3EQF, 3E8N, 3W8Q, 3DV3, 3EQD, 3EQI, 6NYB, 4ANB, 4AN2, 1S9J, 3MBL, 4MNE, 3SLS, 3ZLX, 5EYM, 5YT3, 3EQH, 6PP9, 3EQC, 6Q0J, 3DY7, 4U81, 5BX0, 4AN9, 3ZLW

ZINC - Investigational

MP2K1_HUMAN

ZINC - Metabolites

MP2K1_HUMAN

COSMIC

COSM555601, COSM1315829

IntEnz

2.7.12.2

GeneCards

Q02750

HPA

ENSG00000169032-MAP2K1

Ensembl

ENSG00000169032, ENSP00000302486, ENST00000307102

Orphanet

16377

ZINC - Predictions - Purchasable

MP2K1_HUMAN

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15056 BRAF	68	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.977	60
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.955	37
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.758	7
UniProt:Q8IVT5 KSR1	5	p-S311,Y552 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y552 KSR1 [cytosol] (R-HSA-5672656) p-S311 KSR1 [cytosol] (R-HSA-5672652) KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654)	0.725	9
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.643	4
UniProt:P28482 MAPK1	18	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.609	2
UniProt:Q8WWU5-7 TCP11			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.556	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
UniProt:Q86Y07 VRK2			0.524	2
UniProt:Q61097	5	Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672654) phospho-Ksr1 [cytosol] (R-MMU-5672652) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672656)	0.508	2
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.508	5
UniProt:P27361 MAPK3	6	p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724)	0.499	2
UniProt:Q86Y07-1 VRK2			0.499	2
UniProt:Q96S96 PEBP4			0.462	3
UniProt:O75832 PSMD10	2	PSMD10 [cytosol] (R-HSA-68788) PSMD10 [nucleoplasm] (R-HSA-174322)	0.462	2

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