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MAP2K1 F53C [cytosol]
Stable Identifier
R-HSA-9652028
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MEK1, Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1), Dual specificity mitogen-activated protein kinase kinase 1 , MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MAP2K mutants (Homo sapiens)
MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
MAP2K1 and MAP2K2 mutants [cytosol] (Homo sapiens)
MAP2K1 F53C dimer [cytosol] (Homo sapiens)
MAP2K1 F53C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02750 MAP2K1
Gene Names
MAP2K1, MEK1, PRKMK1
Chain
chain:1-393
Reference Genes
BioGPS Gene:5604 MAP2K1
COSMIC (genes):MAP2K1 MAP2K1
CTD Gene:5604 MAP2K1
dbSNP Gene:5604 MAP2K1
ENSEMBL:ENSG00000169032 MAP2K1
HGNC:6840 MAP2K1
KEGG Gene (Homo sapiens):5604 MAP2K1
Monarch:5604 MAP2K1
NCBI Gene:5604 MAP2K1
OMIM:176872 MAP2K1
UCSC:Q02750 MAP2K1
Reference Transcript
RefSeq:XM_017022411.1 MAP2K1
RefSeq:NM_002755.3 MAP2K1
Other Identifiers
0001740347
1130_at
11717291_a_at
11749555_a_at
11757478_s_at
16802190
1844_s_at
202670_at
3092255
3092256
3092263
3092264
3598663
3598664
3598670
3598671
3598672
3598673
3598688
3598690
3598691
3598692
3598696
3598697
3598700
3598701
3598702
5604
7984319
A_23_P20248
GE57608
GO:0000003
GO:0000165
GO:0000166
GO:0000187
GO:0000902
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0006935
GO:0006950
GO:0007049
GO:0007050
GO:0007165
GO:0007507
GO:0007568
GO:0008022
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018107
GO:0018108
GO:0019899
GO:0021697
GO:0030154
GO:0030182
GO:0030216
GO:0030234
GO:0030674
GO:0030878
GO:0031410
GO:0032872
GO:0034641
GO:0040011
GO:0043167
GO:0043226
GO:0043539
GO:0045597
GO:0045893
GO:0047485
GO:0048538
GO:0048646
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060020
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070371
GO:0070374
GO:0071902
GO:0090170
GO:0090398
GO:0097110
GO:1903800
GO:2000641
Hs.3446.0.A2_3p_at
ILMN_1694240
L05624_s_at
L11284_at
PH_hs_0022483
TC15000613.hg
Participant Of
hasComponent
MAP2K1 F53C dimer [cytosol]
Other forms of this molecule
MAP2K1(9-393) [cytosol]
MAP2K1(2-8) [cytosol]
MAP2K1 F53S [cytosol]
MAP2K1 D67N [cytosol]
MAP2K1 Q56P [cytosol]
MAP2K1 E203K [cytosol]
MAP2K1 V60E [cytosol]
MAP2K1 P124S [cytosol]
MAP2K1 Y130C [cytosol]
MAP2K1 C121S [cytosol]
MAP2K1 G128V [cytosol]
MAP2K1 F53L [cytosol]
MAP2K1 K57N [cytosol]
MAP2K1 K57T [cytosol]
MAP2K1 F53V [cytosol]
MAP2K1 D67Y [cytosol]
MAP2K1 G128D [cytosol]
MAP2K1 P124L [cytosol]
MAP2K1 F53Y [cytosol]
MAP2K1 E44_E57del [cytosol]
MAP2K1 P124Q [cytosol]
p-S,218, S222,T292 MAP2K1 [cytosol]
MAP2K1 [cytosol]
p-T286,T292-MAP2K1 [cytosol]
p-S218,S222,T286,T292-MAP2K1 [cytosol]
p-S218,S222-MAP2K1 [cytosol]
Modified Residues
Name
L-phenylalanine 53 replaced with L-cysteine
Coordinate
53
PsiMod
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
L-phenylalanine removal [MOD:01644]
A protein modification that effectively removes or replaces an L-phenylalanine.
Disease
Name
Identifier
Synonyms
hematologic cancer
2531
hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
lung cancer
1324
Cross References
RefSeq
NP_002746.1
,
XP_016877900.1
ZINC - World Drugs
MP2K1_HUMAN
OpenTargets
ENSG00000169032
ZINC - FDA approved
MP2K1_HUMAN
ZINC - Substances
MP2K1_HUMAN
ZINC target
Q02750
ZINC - Biogenic
MP2K1_HUMAN
PRO
Q02750
PDB
6Q0J
,
4MNE
,
3ZLW
,
6PP9
,
3ZLS
,
3EQB
,
6U2G
,
3DV3
,
6Q0T
,
3OS3
,
6X2P
,
3MBL
,
6X2X
,
6NYB
,
3ORN
,
4LMN
,
3DY7
,
3PP1
,
3V04
,
4AN9
,
4U7Z
,
3EQF
,
3V01
,
4AN3
,
3SLS
,
3EQD
,
3WIG
,
4AN2
,
3EQC
,
3E8N
,
3W8Q
,
5HZE
,
3EQI
,
5YT3
,
4ANB
,
6X2S
,
3EQH
,
4ARK
,
5BX0
,
2P55
,
5EYM
,
4U80
,
3ZM4
,
3ZLY
,
3EQG
,
4U81
,
3ZLX
,
3VVH
,
1S9J
ZINC - Investigational
MP2K1_HUMAN
ZINC - Metabolites
MP2K1_HUMAN
COSMIC
COSM1562837
GeneCards
Q02750
HPA
ENSG00000169032-MAP2K1
Ensembl
ENSP00000302486
,
ENST00000307102
,
ENSG00000169032
ZINC - Predictions - Purchasable
MP2K1_HUMAN
Orphanet
16377
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15056 BRAF
68
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF [cytosol]
(R-HSA-167224)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.977
60
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.955
37
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.758
7
UniProt:Q8IVT5 KSR1
5
p-S311,Y552 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y552 KSR1 [cytosol]
(R-HSA-5672656)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
0.725
9
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.643
4
UniProt:P28482 MAPK1
18
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.609
2
UniProt:Q8WWU5-7 TCP11
0.556
3
UniProt:Q8N9N5-2 BANP
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.556
3
UniProt:P46937 YAP1
7
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
0.556
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
4
UniProt:Q86Y07 VRK2
0.524
2
UniProt:Q61097
5
Ksr1 [cytosol]
(R-MMU-5672587)
phospho-Ksr1 [cytosol]
(R-MMU-5672654)
phospho-Ksr1 [cytosol]
(R-MMU-5672652)
phospho-Ksr1 [plasma membrane]
(R-MMU-5672659)
phospho-Ksr1 [cytosol]
(R-MMU-5672656)
0.508
2
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.508
5
UniProt:Q86Y07-1 VRK2
0.499
2
UniProt:P27361 MAPK3
6
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
0.499
2
UniProt:Q96S96 PEBP4
0.462
3
UniProt:O75832 PSMD10
2
PSMD10 [cytosol]
(R-HSA-68788)
PSMD10 [nucleoplasm]
(R-HSA-174322)
0.462
2
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