Reactome | p-T185,Y187 MAPK1 D321N [cytosol]

p-T185,Y187 MAPK1 D321N [cytosol]

Stable Identifier

R-HSA-9652785

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ERK2, Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1), Mitogen-activated protein kinase 1 , Extracellular signal-regulated kinase 2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1, ERK-2

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Literature References

PubMed ID	Title	Journal	Year
27760319	Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants Pantel, S, Garraway, LA, Johannessen, CM, Cacchiarelli, D, Getz, G, Persky, NS, Brenan, L, Piccioni, F, Cohen, O, Root, DE, Goetz, EM, Zhu, C, Andreev, A, Burgin, AB, Mikkelsen, TS, Bagul, M, Kamburov, A	Cell Rep	2016
21798897	Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 Hruban, RH, Xie, TX, Myers, JN, Wood, LD, EL-Naggar, AK, Papadopoulos, N, Frederick, MJ, Wang, J, Chang, K, Treviño, L, Bettegowda, C, Zhang, N, Fakhry, C, Drummond, JA, Weinstein, JN, Kinzler, KW, Zhang, J, Wheeler, DA, Vogelstein, B, Wu, Y, Agrawal, N, Koch, WM, Li, RJ, Velculescu, VE, Westra, WH, Jasser, SA, Pickering, CR, Muzny, DM, Gibbs, RA, Sidransky, D, Califano, JA	Science	2011

External Reference Information

External Reference

UniProt:P28482 MAPK1

Gene Names

MAPK1, ERK2, PRKM1, PRKM2

Chain

initiator methionine:, chain:2-360

Reference Genes

BioGPS Gene:5594 MAPK1

COSMIC (genes):MAPK1 MAPK1

CTD Gene:5594 MAPK1

dbSNP Gene:5594 MAPK1

ENSEMBL:ENSG00000100030 MAPK1

ENSEMBL_homo_sapiens_GENE:ENSG00000100030.15 MAPK1

HGNC:6871 MAPK1

KEGG Gene (Homo sapiens):5594 MAPK1

Monarch:5594 MAPK1

NCBI Gene:5594 MAPK1

OMIM:176948 MAPK1

UCSC:P28482 MAPK1

Reference Transcript

Other Identifiers

11715841_at

11715842_a_at

11715843_at

11738871_a_at

11738872_x_at

11751223_a_at

11751224_x_at

11753379_a_at

1552263_PM_at

1552263_at

1552264_PM_a_at

1552264_a_at

16932831

208351_PM_s_at

208351_s_at

212271_PM_at

212271_at

224621_PM_at

224621_at

3954239

3954240

3954241

3954242

3954243

3954244

3954245

3954246

3954248

3954249

3954252

3954256

3954257

3954261

3954262

3954264

3954266

3954273

3954274

45715_at

55528_at

5594

8074791

976_s_at

A_23_P257895

A_24_P237265

GE476071

GE534117

GE56878

GE86009

GO:0000165

GO:0000166

GO:0001784

GO:0002376

GO:0003677

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005783

GO:0005788

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005901

GO:0005925

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0006915

GO:0006935

GO:0006974

GO:0007010

GO:0007049

GO:0007165

GO:0007166

GO:0007268

GO:0007507

GO:0007611

GO:0008286

GO:0008353

GO:0009887

GO:0010759

GO:0010800

GO:0012501

GO:0014032

GO:0014044

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019858

GO:0019902

GO:0023052

GO:0030154

GO:0030278

GO:0030521

GO:0030641

GO:0030878

GO:0031143

GO:0031410

GO:0031647

GO:0031663

GO:0032200

GO:0032212

GO:0032496

GO:0032872

GO:0033554

GO:0033598

GO:0034198

GO:0034614

GO:0035094

GO:0035556

GO:0035578

GO:0036211

GO:0038127

GO:0038133

GO:0042473

GO:0042552

GO:0042802

GO:0043226

GO:0043330

GO:0043401

GO:0045202

GO:0045596

GO:0048009

GO:0048538

GO:0048856

GO:0048870

GO:0050847

GO:0050852

GO:0050853

GO:0050877

GO:0051403

GO:0051493

GO:0051973

GO:0055086

GO:0060020

GO:0060291

GO:0060324

GO:0060425

GO:0060440

GO:0060716

GO:0061308

GO:0070161

GO:0070371

GO:0070849

GO:0071276

GO:0071356

GO:0072584

GO:0072686

GO:0090170

GO:0106310

GO:0120041

GO:0140096

GO:1904355

GO:1904813

GO:2000641

HMNXSV003015938

HMNXSV003030947

Hs.324473.2.S1_3p_at

Hs.66151.0.S1_3p_at

Hs2.324473.2.S1_3p_at

ILMN_1706677

ILMN_1767320

ILMN_2235283

PH_hs_0016141

PH_hs_0039033

TC22000547.hg

Z11695_at

g4506086_3p_a_at

Participates

as a member of

constitutively active MAPK1 mutants [cytosol] (Homo sapiens)

Other forms of this molecule

MAPK1 [endoplasmic reticulum lumen]

MAPK1 [ficolin-1-rich granule lumen]

MAPK1 [extracellular region]

MAPK1 [azurophil granule lumen]

p-T185,Y187 MAPK1 E322V [cytosol]

p-T185,Y187 MAPK1 E322K [cytosol]

p-T185,Y187 MAPK1 E81K [cytosol]

p-T185,Y187 MAPK1 S142L [cytosol]

p-T185,Y187 MAPK1 P58L [cytosol]

p-T185,Y187 MAPK1 D321V [cytosol]

p-T185,Y187 MAPK1 E322A [cytosol]

p-T185,Y187 MAPK1 P58G [cytosol]

p-T185-MAPK1 [cytosol]

MAPK1 [nucleoplasm]

MAPK1 [cytosol]

p-T185,Y187-MAPK1 [cytosol]

p-T185,Y187-MAPK1 [nucleoplasm]

Modified Residues

Name

L-aspartic acid 321 replaced with L-asparagine

Coordinate

321

PsiMod

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

L-asparagine residue [MOD:00012]

A protein modification that effectively converts a source amino acid residue to an L-asparagine.

Name

O4'-phospho-L-tyrosine at 185

Coordinate

185

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 187

Coordinate

187

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
head and neck squamous cell carcinoma	DOID:5520	carcinoma of the head and neck, squamous cell carcinoma of the head and neck

Cross References

RefSeq

NP_002736.3, NP_620407.1

ZINC - World Drugs

MK01_HUMAN

Guide to Pharmacology - Targets

1495

OpenTargets

ENSG00000100030

ZINC - FDA approved

MK01_HUMAN

ZINC - Substances

MK01_HUMAN

ZINC target

P28482

ZINC - Biogenic

MK01_HUMAN

PRO

P28482

PDB

5AX3, 5WP1, 3TEI, 6G9M, 6QA4, 7NR9, 3I5Z, 4O6E, 6QA3, 3W55, 8AOH, 6G9A, 8AO6, 4FV7, 4NIF, 6DMG, 8AOG, 4ZZO, 2OJJ, 5V60, 2Y9Q, 5BVD, 4FV9, 5K4I, 7NR3, 4FMQ, 5NHH, 7W5O, 4FUY, 4QTE, 6G9D, 3SA0, 8AO7, 5LCJ, 3D44, 6G9J, 7NR5, 6G92, 4FV2, 5LCK, 8AOE, 6G9N, 6Q7K, 5NHO, 4FV4, 4IZ7, 5BUJ, 4QP8, 7XC1, 6QAW, 2OJI, 4H3Q, 7OPM, 6Q7S, 5V62, 8AO5, 8AOF, 6NBS, 8AO4, 1TVO, 6QAL, 4G6O, 6G9H, 6G91, 4FV1, 6GDM, 4QP2, 4QP3, 1PME, 5NHL, 6D5Y, 6GE0, 6GDQ, 6QAQ, 5BVF, 6OPI, 4ZZM, 4QP7, 8AO3, 3I60, 8AOD, 8AO2, 6G93, 4ZZN, 8AOC, 6OPH, 4FV6, 4IZA, 4QTA, 7X4U, 6GJD, 7NQW, 5NHF, 4QPA, 4FV8, 6QAH, 6QAG, 1WZY, 4XJ0, 6Q7T, 6GJB, 7NQQ, 6OPG, 8AOB, 3D42, 6QA1, 8AOA, 4IZ5, 4FV3, 7E73, 6G97, 7AUV, 5NHP, 4QP9, 4ZXT, 5BUI, 2OJG, 4FV5, 4N0S, 4H3P, 5V61, 5NHV, 6RQ4, 5NGU, 6SLG, 7E75, 4QP1, 4G6N, 8AO9, 8AOJ, 4FV0, 8AO8, 8U8J, 8AOI, 4FUX, 6G54, 8U8K, 7NR8, 5NHJ, 4QP4, 5BVE, 6G9K, 6G8X, 4QP6, 5BUE

ZINC - Investigational

MK01_HUMAN

ZINC - Metabolites

MK01_HUMAN

COSMIC

COSV53186174

IntEnz

2.7.11.24

GeneCards

P28482

HPA

ENSG00000100030-MAPK1

Ensembl

ENSP00000215832, ENSP00000440842, ENST00000398822, ENSP00000381803, ENSG00000100030, ENST00000215832, ENST00000544786

Pharos - Targets

P28482

Orphanet

17413

ZINC - Predictions - Purchasable

MK01_HUMAN

HMDB Protein

HMDBP01190

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15349 RPS6KA2	7	RPS6KA2 [nucleoplasm] (R-HSA-199861) p-4S,T356,T570-RPS6KA2 [nucleoplasm] (R-HSA-199871) RPS6KA2 [cytosol] (R-HSA-444252) p-T356,S360,T570-RPS6KA2 [cytosol] (R-HSA-9619955) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619869) p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619984) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (R-HSA-444290)	0.914	12
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.896	12
UniProt:P51812 RPS6KA3	7	RPS6KA3 [nucleoplasm] (R-HSA-199869) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [cytosol] (R-HSA-444250) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286)	0.878	12
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.818	11
UniProt:Q13115 DUSP4	1	DUSP4 [nucleoplasm] (R-HSA-203794)	0.806	6
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.774	8
UniProt:P35236 PTPN7	2	PTPN7 [nucleoplasm] (R-HSA-9008913) PTPN7 [cytosol] (R-HSA-9635737)	0.767	6
UniProt:Q16828 DUSP6	2	DUSP6 [cytosol] (R-HSA-5675343) DUSP6 [nucleoplasm] (R-HSA-2871619)	0.758	5
UniProt:Q15121 PEA15	1	PEA15 [cytosol] (R-HSA-5675204)	0.75	5
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.738	5
UniProt:P0A2M9 SPVC			0.683	3
UniProt:Q15256 PTPRR			0.682	4
UniProt:Q8VSP9 OSPF			0.672	5
UniProt:A2A3K4 PTPC1			0.666	4
UniProt:Q9BRK4 LZTS2			0.666	4
UniProt:P49366 DHPS	1	DHPS [cytosol] (R-HSA-204630)	0.643	10
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.643	5
UniProt:P54829 PTPN5	1	PTPN5 [nucleoplasm] (R-HSA-9008908)	0.643	3
UniProt:Q16539-3 MAPK14			0.628	5
UniProt:P02687 MBP			0.623	2
UniProt:P29353-2 SHC1	6	SHC1-2 [plasma membrane] (R-HSA-2404168) p-S29,3Y-SHC1-2 [cytosol] (R-HSA-8934453) SHC1-2 [cytosol] (R-HSA-1169488) p-Y317-SHC1-2 [cytosol] (R-HSA-8851895) p-Y239,Y240,Y317-SHC1-2 [cytosol] (R-HSA-1433505) p-Y239,Y240,Y317-SHC1-2 [plasma membrane] (R-HSA-1169507)	0.618	4
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.611	19
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.609	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.609	2
UniProt:Q16829 DUSP7	2	DUSP7 [cytosol] (R-HSA-5675346) DUSP7 [nucleoplasm] (R-HSA-203791)	0.59	2
UniProt:Q9Y296 TRAPPC4	2	TRAPPC4 [plasma membrane] (R-HSA-2682314) TRAPPC4 [cytosol] (R-HSA-5683764)	0.581	3
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.578	7
UniProt:Q05922	1	Dusp2 [nucleoplasm] (R-MMU-5675340)	0.558	2
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q15256-5 PTPRR			0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:P35548 MSX2	1	MSX2 [nucleoplasm] (R-HSA-9007760)	0.556	3
UniProt:A0A384NQ31 A0A384NQ31			0.556	3
UniProt:P15882 CHN1	1	CHN1 [cytosol] (R-HSA-2980571)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9UPG8 PLAL2			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.556	3
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.544	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.544	2
UniProt:Q16690 DUSP5	1	DUSP5 [nucleoplasm] (R-HSA-5675342)	0.543	3
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.528	3
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.527	2
UniProt:Q9HBH9 MKNK2			0.527	2
UniProt:Q8IWJ2 GCC2	3	GCC2 [cytosol] (R-HSA-6813880) GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9713455) GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] (R-HSA-9713458)	0.527	3
UniProt:Q92576 PHF3			0.527	2
UniProt:Q15256-3 PTPRR			0.527	2
UniProt:Q9U1H0 CIC			0.527	2
UniProt:Q9Y573 IPP			0.527	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.524	2
UniProt:P53004 BLVRA	1	BLVRA [cytosol] (R-HSA-189390)	0.499	2
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.488	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	3
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2

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