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KRAS K117N [plasma membrane]
Stable Identifier
R-HSA-9653095
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
RAS GTPase cycle mutants (Homo sapiens)
RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
RAS GAP mutants [plasma membrane] (Homo sapiens)
KRAS K117N [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20147967
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine
Smith, G
,
Bounds, R
,
Wolf, H
,
Steele, RJ
,
Carey, FA
,
Wolf, CR
Br. J. Cancer
2010
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703 KRAS
HGNC:6407 KRAS
KEGG Gene (Homo sapiens):3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
RefSeq:NM_004985.4 KRAS
RefSeq:XM_011520653.2 KRAS
RefSeq:XM_006719069.3 KRAS
RefSeq:NM_033360.3 KRAS
Other Identifiers
0006110070
0007040129
11717962_x_at
11717963_a_at
11717964_a_at
11717965_s_at
16762399
1940_at
204009_s_at
204010_s_at
214352_s_at
231640_at
32159_at
3447860
3447862
3447864
3447865
3447866
3447867
3447868
3447869
3447870
3447871
3447872
3447873
3447874
3447879
3447880
3447884
3447886
3845
3958621
7961865
A_23_P306500
A_23_P306507
A_23_P45140
A_33_P3317815
GE61031
GO:0000003
GO:0000165
GO:0000166
GO:0001889
GO:0001934
GO:0002223
GO:0002376
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005925
GO:0006464
GO:0006950
GO:0007010
GO:0007165
GO:0007265
GO:0007267
GO:0007565
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008542
GO:0009058
GO:0010628
GO:0016020
GO:0016787
GO:0019002
GO:0019003
GO:0019221
GO:0021897
GO:0030036
GO:0030154
GO:0030275
GO:0031234
GO:0031647
GO:0032228
GO:0034641
GO:0035022
GO:0035900
GO:0038002
GO:0042592
GO:0042802
GO:0043167
GO:0043226
GO:0043406
GO:0043524
GO:0044877
GO:0045121
GO:0045596
GO:0048169
GO:0048856
GO:0048873
GO:0050877
GO:0051000
GO:0051092
GO:0051146
GO:0051384
GO:0051385
GO:0060441
GO:2000774
HMNXSV003005517
HMNXSV003016084
Hs.184050.0.S1_3p_a_at
Hs.184050.1.A1_3p_a_at
Hs.184050.4.A1_3p_at
ILMN_1652104
ILMN_1728071
M54968_at
PH_hs_0028364
PH_hs_0030345
TC12001314.hg
g4826811_3p_a_at
Participates
as a member of
RAS GAP mutants [plasma membrane] (Homo sapiens)
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS A146T [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS G12C [plasma membrane]
KRAS L19F [plasma membrane]
KRAS G12D [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS V14I [plasma membrane]
KRAS G12V [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G13D [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G60R [plasma membrane]
KRAS D33E [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS G60V [plasma membrane]
KRAS G60D [plasma membrane]
KRAS E63K [plasma membrane]
KRAS A59T [plasma membrane]
proKRAS [cytosol]
S-Farn-proKRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
KRAS [plasma membrane]
Modified Residues
Name
L-lysine 117 replaced with L-asparagine
Coordinate
117
PsiMod
L-lysine removal [MOD:01642]
A protein modification that effectively removes or replaces an L-lysine.
L-asparagine residue [MOD:00012]
A protein modification that effectively converts a source amino acid residue to an L-asparagine.
Disease
Name
Identifier
Synonyms
hematologic cancer
DOID:2531
hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
colorectal cancer
DOID:9256
Cross References
RefSeq
XP_011518955.1
,
NP_203524.1
,
XP_006719132.1
,
NP_004976.2
COSMIC
COSV55504752
,
COSV55545304
,
COSM30612
OpenTargets
ENSG00000133703
HPA
ENSG00000133703-KRAS
GeneCards
P01116
ZINC - Substances
RASK_HUMAN
ZINC target
P01116
Ensembl
ENSP00000256078
,
ENSP00000308495
,
ENSG00000133703
,
ENST00000311936
,
ENST00000256078
PRO
P01116
Orphanet
16312
PDB
5W22
,
4M1Y
,
1N4S
,
5V9L
,
5UFQ
,
5VPZ
,
5WHD
,
4PZZ
,
4LYF
,
6FA1
,
1D8D
,
5KYK
,
4TQ9
,
5WHB
,
6CCX
,
6UT0
,
6CCH
,
5WPM
,
5V6V
,
1N4Q
,
6O53
,
6W4E
,
6PGP
,
6BP1
,
6MBU
,
6GJ6
,
6GQT
,
5UK9
,
6BOF
,
6OB2
,
6H47
,
3GFT
,
4EPW
,
6EPP
,
6EPM
,
6O4Z
,
5O2T
,
4PZY
,
6GQY
,
6P8Z
,
6GOE
,
4M1O
,
5OCG
,
6YR8
,
6QUU
,
4LYH
,
5VQ2
,
5WLB
,
1N4P
,
6P8W
,
6CC9
,
4M1W
,
6GJ7
,
6USX
,
4M22
,
6GQW
,
4DSN
,
6EPO
,
6MBQ
,
4EPX
,
6MNX
,
6EPL
,
6O51
,
4M1T
,
4QL3
,
5VQ0
,
6F76
,
6GOF
,
4Q02
,
5VPI
,
1D8E
,
4NMM
,
4LYJ
,
6V65
,
6T5V
,
6N2J
,
4EPR
,
5V6S
,
4Q03
,
5US4
,
4M1S
,
6FA4
,
6JTO
,
6T5U
,
6N2K
,
6H46
,
4LV6
,
6JTN
,
6EPN
,
4EPV
,
5V71
,
4LRW
,
4EPY
,
6QUX
,
6GOD
,
6PGO
,
6FA3
,
6GQX
,
6MBT
,
1KZO
,
5OCT
,
4Q01
,
4DSO
,
6ASA
,
6GOG
,
5VPY
,
6CU6
,
4EPT
,
6M9W
,
6OIM
,
5VQ1
,
5YY1
,
6V5L
,
6PQ3
,
5VP7
,
5V9U
,
6ASE
,
6B0V
,
4M21
,
6FA2
,
5VBM
,
6WGN
,
6MQN
,
4OBE
,
1N4R
,
6ARK
,
6O4Y
,
4LUC
,
6PTS
,
6E6G
,
6MTA
,
6TAN
,
5YXZ
,
6YXW
,
5VQ6
,
5UFE
,
5F2E
,
5WHA
,
6O46
,
4LPK
,
4L8G
,
6MS9
,
6T5B
,
5OCO
,
6USZ
,
6TAM
,
6GOM
,
6O36
,
6W4F
,
6V6F
,
6ZLI
,
6MQG
,
6E6F
,
6QUW
,
6P8X
,
1KZP
,
5O2S
,
4LDJ
,
5TAR
,
5VQ8
,
4WA7
,
4TQA
,
6JTP
,
6P0Z
,
6QUV
,
5UQW
,
5V9O
,
6P8Y
,
5TB5
,
6B0Y
,
5USJ
,
5MLA
,
6GJ8
,
5MLB
,
5XCO
,
6PTW
,
6OB3
,
5WHE
,
6ZL5
,
6GJ5
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
54
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
RAF1 [cytosol]
(R-HSA-167205)
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.623
5
UniProt:Q96II5 Q96II5
0.556
3
UniProt:P50749 RASF2
0.544
2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
6
PI(3,4,5)P3 [endocytic vesicle membrane]
(R-ALL-917725)
PIP3 [plasma membrane]
(R-ALL-38117)
PI(3,4,5)P3 [endosome membrane]
(R-ALL-917716)
PI(3,4,5)P3 [early endosome membrane]
(R-ALL-8849955)
PI(3,4,5)P3 [cytoplasmic vesicle membrane]
(R-ALL-8874468)
PI(3,4,5)P3 [plasma membrane]
(R-ALL-179838)
0.462
2
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