Reactome | KRAS L19F [plasma membrane]

KRAS L19F [plasma membrane]

Stable Identifier

R-HSA-9653097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - RAS GTPase cycle mutants (Homo sapiens)
        
        RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
        
        RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
        
        RAS GAP mutants [plasma membrane] (Homo sapiens)
        
        KRAS L19F [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17150185	Characterization of a novel oncogenic K-ras mutation in colon cancer Akagi, K, Uchibori, R, Yamaguchi, K, Kurosawa, K, Tanaka, Y, Kozu, T	Biochem. Biophys. Res. Commun.	2007
20147967	Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine Smith, G, Bounds, R, Wolf, H, Steele, RJ, Carey, FA, Wolf, CR	Br. J. Cancer	2010

External Reference Information

External Reference

UniProt:P01116 KRAS

Gene Names

KRAS, KRAS2, RASK2

Chain

initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189

Reference Genes

BioGPS Gene:3845 KRAS

COSMIC (genes):KRAS KRAS

CTD Gene:3845 KRAS

dbSNP Gene:3845 KRAS

ENSEMBL:ENSG00000133703 KRAS

HGNC:6407 KRAS

KEGG Gene (Homo sapiens):3845 KRAS

Monarch:3845 KRAS

NCBI Gene:3845 KRAS

OMIM:190070 KRAS

UCSC:P01116 KRAS

Reference Transcript

Other Identifiers

0006110070

0007040129

11717962_x_at

11717963_a_at

11717964_a_at

11717965_s_at

16762399

1940_at

204009_s_at

204010_s_at

214352_s_at

231640_at

32159_at

3447860

3447862

3447864

3447865

3447866

3447867

3447868

3447869

3447870

3447871

3447872

3447873

3447874

3447879

3447880

3447884

3447886

3845

3958621

7961865

A_23_P306500

A_23_P306507

A_23_P45140

A_33_P3317815

GE61031

GO:0000003

GO:0000165

GO:0000166

GO:0001889

GO:0001934

GO:0002223

GO:0002376

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005925

GO:0006464

GO:0006950

GO:0007010

GO:0007165

GO:0007265

GO:0007267

GO:0007565

GO:0007568

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008542

GO:0009058

GO:0010628

GO:0016020

GO:0016787

GO:0019002

GO:0019003

GO:0019221

GO:0021897

GO:0030036

GO:0030154

GO:0030275

GO:0031234

GO:0031647

GO:0032228

GO:0034641

GO:0035022

GO:0035900

GO:0038002

GO:0042592

GO:0042802

GO:0043167

GO:0043226

GO:0043406

GO:0043524

GO:0044877

GO:0045121

GO:0045596

GO:0048169

GO:0048856

GO:0048873

GO:0050877

GO:0051000

GO:0051092

GO:0051146

GO:0051384

GO:0051385

GO:0060441

GO:2000774

HMNXSV003005517

HMNXSV003016084

Hs.184050.0.S1_3p_a_at

Hs.184050.1.A1_3p_a_at

Hs.184050.4.A1_3p_at

ILMN_1652104

ILMN_1728071

M54968_at

PH_hs_0028364

PH_hs_0030345

TC12001314.hg

g4826811_3p_a_at

Participates

as a member of

RAS GAP mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

S-Farn-Me-PalmS KRAS [plasma membrane]

p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]

KRAS A146T [plasma membrane]

KRAS K147E [plasma membrane]

KRAS K147T [plasma membrane]

KRAS V14G [plasma membrane]

KRAS K147N [plasma membrane]

KRAS A146V [plasma membrane]

KRAS A146S [plasma membrane]

KRAS A146P [plasma membrane]

KRAS P34R [plasma membrane]

KRAS P34L [plasma membrane]

KRAS G12A [plasma membrane]

KRAS G12R [plasma membrane]

KRAS G13V [plasma membrane]

KRAS G13S [plasma membrane]

KRAS G13C [plasma membrane]

KRAS G13R [plasma membrane]

KRAS G13A [plasma membrane]

KRAS K5N [plasma membrane]

KRAS G12S [plasma membrane]

KRAS Q61L [plasma membrane]

KRAS Q61K [plasma membrane]

KRAS Q61R [plasma membrane]

KRAS F156L [plasma membrane]

KRAS G12C [plasma membrane]

KRAS G12D [plasma membrane]

KRAS Q22E [plasma membrane]

KRAS K117N [plasma membrane]

KRAS Q22R [plasma membrane]

KRAS Q61H [plasma membrane]

KRAS V14I [plasma membrane]

KRAS G12V [plasma membrane]

KRAS D153V [plasma membrane]

KRAS G13D [plasma membrane]

KRAS T58I [plasma membrane]

KRAS G60R [plasma membrane]

KRAS D33E [plasma membrane]

KRAS Q22K [plasma membrane]

KRAS G60V [plasma membrane]

KRAS G60D [plasma membrane]

KRAS E63K [plasma membrane]

KRAS A59T [plasma membrane]

proKRAS [cytosol]

S-Farn-proKRAS [endoplasmic reticulum membrane]

S-Farn-Me KRAS [endoplasmic reticulum membrane]

S-Farn-KRAS [endoplasmic reticulum membrane]

KRAS [plasma membrane]

Modified Residues

Name

L-leucine 19 replaced with L-phenylalanine

Coordinate

PsiMod

L-leucine removal [MOD:01641]

A protein modification that effectively removes or replaces an L-leucine.

L-phenylalanine residue [MOD:00023]

A protein modification that effectively converts a source amino acid residue to L-phenylalanine.

Disease

Name	Identifier	Synonyms
colorectal cancer	DOID:9256
urinary system cancer	DOID:3996
hematologic cancer	DOID:2531	hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)

Cross References

RefSeq

XP_011518955.1, NP_203524.1, XP_006719132.1, NP_004976.2

COSMIC

COSV55502103, COSV55521217

OpenTargets

ENSG00000133703

HPA

ENSG00000133703-KRAS

GeneCards

P01116

ZINC - Substances

RASK_HUMAN

ZINC target

P01116

Ensembl

ENSP00000256078, ENSP00000308495, ENSG00000133703, ENST00000311936, ENST00000256078

PRO

P01116

Orphanet

16312

PDB

5W22, 4M1Y, 1N4S, 5V9L, 5UFQ, 5VPZ, 5WHD, 4PZZ, 4LYF, 6FA1, 1D8D, 5KYK, 4TQ9, 5WHB, 6CCX, 6UT0, 6CCH, 5WPM, 5V6V, 1N4Q, 6O53, 6W4E, 6PGP, 6BP1, 6MBU, 6GJ6, 6GQT, 5UK9, 6BOF, 6OB2, 6H47, 3GFT, 4EPW, 6EPP, 6EPM, 6O4Z, 5O2T, 4PZY, 6GQY, 6P8Z, 6GOE, 4M1O, 5OCG, 6YR8, 6QUU, 4LYH, 5VQ2, 5WLB, 1N4P, 6P8W, 6CC9, 4M1W, 6GJ7, 6USX, 4M22, 6GQW, 4DSN, 6EPO, 6MBQ, 4EPX, 6MNX, 6EPL, 6O51, 4M1T, 4QL3, 5VQ0, 6F76, 6GOF, 4Q02, 5VPI, 1D8E, 4NMM, 4LYJ, 6V65, 6T5V, 6N2J, 4EPR, 5V6S, 4Q03, 5US4, 4M1S, 6FA4, 6JTO, 6T5U, 6N2K, 6H46, 4LV6, 6JTN, 6EPN, 4EPV, 5V71, 4LRW, 4EPY, 6QUX, 6GOD, 6PGO, 6FA3, 6GQX, 6MBT, 1KZO, 5OCT, 4Q01, 4DSO, 6ASA, 6GOG, 5VPY, 6CU6, 4EPT, 6M9W, 6OIM, 5VQ1, 5YY1, 6V5L, 6PQ3, 5VP7, 5V9U, 6ASE, 6B0V, 4M21, 6FA2, 5VBM, 6WGN, 6MQN, 4OBE, 1N4R, 6ARK, 6O4Y, 4LUC, 6PTS, 6E6G, 6MTA, 6TAN, 5YXZ, 6YXW, 5VQ6, 5UFE, 5F2E, 5WHA, 6O46, 4LPK, 4L8G, 6MS9, 6T5B, 5OCO, 6USZ, 6TAM, 6GOM, 6O36, 6W4F, 6V6F, 6ZLI, 6MQG, 6E6F, 6QUW, 6P8X, 1KZP, 5O2S, 4LDJ, 5TAR, 5VQ8, 4WA7, 4TQA, 6JTP, 6P0Z, 6QUV, 5UQW, 5V9O, 6P8Y, 5TB5, 6B0Y, 5USJ, 5MLA, 6GJ8, 5MLB, 5XCO, 6PTW, 6OB3, 5WHE, 6ZL5, 6GJ5

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	54	p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) RAF1 [cytosol] (R-HSA-167205) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.623	5
UniProt:Q96II5 Q96II5			0.556	3
UniProt:P50749 RASF2			0.544	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2

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