Reactome | pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane

pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane

Stable Identifier

R-HSA-9653592

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, plasma membrane

ReviewStatus

5/5

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pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane

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PKC- or -PRKG2-dependent phosphorylation of KRAS4B at serine 181 promotes its trafficking to intracellular membranes, including the mitochondrial outer membrane where it interacts with BCL2L1 (also known as BCL-XL) to promote apoptosis (Bivona et al, 2006; Barcelo et al, 2013; Jang et al, 2015; reviewed in Ahearn et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
23943869	Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status Tebar, F, Beckett, AJ, Agell, N, Barceló, C, Prior, I, Paco, N, Jaumot, M, Alvarez-Moya, B, Garrido, E, Gelabert, M	J. Cell. Sci.	2013
29311131	Posttranslational Modifications of RAS Proteins Philips, MR, Zhou, M, Ahearn, I	Cold Spring Harb Perspect Med	2018
16483930	PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis Philips, MR, Bivona, TG, Thompson, CB, Ahearn, IM, Mor, A, Pérez De Castro, I, Saba, SG, Yim, D, Cox, AD, Bodemann, BO, Wiener, HH, Soskis, MJ, Fein, A, Miura, J, Quatela, SE, Li, C, Wright, L	Mol. Cell	2006
25713064	Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region Nussinov, R, Tarasova, NI, Khavrutskii, L, Jang, H, Abraham, SJ, Gaponenko, V, Hitchinson, B, Chavan, TS	J. Biol. Chem.	2015