Translation of ATF5

Stable Identifier
R-HSA-9653745
Type
Reaction [omitted]
Species
Homo sapiens
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The ATF5 mRNA is translated to yield ATF5 protein (Watatani et al. 2008, and inferred from the mouse homolog) which is then imported into the nucleus. The ATF5 mRNA contains 2 upstream ORFs (uORFs) which inhibit translation of the downstream ATF5 coding region (Watatani et al. 2008). Translation of uORF2 also targets the mRNA for nonsense-mediated decay (Hatano et al. 2013). During stresses such as amino acid limitation and arsenite-induced oxidative stress, EIF2S1 (eIF2-alpha) is phosphorylated, decreasing translation initiation at the uORFs and increasing translation of ATF5 (Watatani et al. 2008, and inferred from the mouse homolog).

Literature References
PubMed ID Title Journal Year
18055463 Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region

Watatani, Y, Ichikawa, K, Nakanishi, N, Fujimoto, M, Takeda, H, Kimura, N, Hirose, H, Takahashi, S, Takahashi, Y

J. Biol. Chem. 2008
23876217 The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress

Hatano, M, Umemura, M, Kimura, N, Yamazaki, T, Takeda, H, Nakano, H, Takahashi, S, Takahashi, Y

FEBS J. 2013
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