Transcription of PPP1R15A

Stable Identifier
R-HSA-9654774
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcription of PPP1R15A
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The PPP1R15A (GADD34) gene is transcribed to yield mRNA (Hollander et al. 1997, Hollander et al. 2001, Oh-Hashi et al. 2001, and inferred from the mouse homolog). Transcription of PPP1R15A is activated by ATF4, which binds the PPP1R15A promoter in response to certain stresses such as endoplasmic reticulum stress, traumatic brain injury, and heme deficiency (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
11241327 Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors

Iglesias, M, Zhan, Q, Yu, K, Fornace, AJ, Sheikh, MS, Woodworth, C, Hollander, MC

Int. J. Cancer 2001
9153226 Mammalian GADD34, an apoptosis- and DNA damage-inducible gene

Zhan, Q, Fornace, AJ, Bae, I, Hollander, MC

J. Biol. Chem. 1997
11163539 Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells

Oh-Hashi, K, Isobe, K, Maruyama, W

Free Radic. Biol. Med. 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ATF4:PPP1R15A gene [nucleoplasm] (Homo sapiens)
Inferred From
Transcription of Ppp1r15a (Mus musculus)
Authored
May, B  (2019-07-18)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-19)
Cite Us!