Reactome | p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]

Stable Identifier

R-HSA-9656043

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf

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Literature References

PubMed ID	Title	Journal	Year
20052757	Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation Kobayashi, T, Aoki, Y, Niihori, T, Cavé, H, Verloes, A, Okamoto, N, Kawame, H, Fujiwara, I, Takada, F, Ohata, T, Sakazume, S, Ando, T, Nakagawa, N, Lapunzina, P, Meneses, AG, Gillessen-Kaesbach, G, Wieczorek, D, Kurosawa, K, Mizuno, S, Ohashi, H, David, A, Philip, N, Guliyeva, A, Narumi, Y, Kure, S, Tsuchiya, S, Matsubara, Y	Hum. Mutat.	2010
26214590	Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas Krauthammer, M, Kong, Y, Bacchiocchi, A, Evans, P, Pornputtapong, N, Wu, C, McCusker, JP, Ma, S, Cheng, E, Straub, R, Serin, M, Bosenberg, M, Ariyan, S, Narayan, D, Sznol, M, Kluger, HM, Mane, S, Schlessinger, J, Lifton, RP, Halaban, R	Nat. Genet.	2015
17603483	Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy Pandit, B, Sarkozy, A, Pennacchio, LA, Carta, C, Oishi, K, Martinelli, S, Pogna, EA, Schackwitz, W, Ustaszewska, A, Landstrom, A, Bos, JM, Ommen, SR, Esposito, G, Lepri, F, Faul, C, Mundel, P, López Siguero, JP, Tenconi, R, Selicorni, A, Rossi, C, Mazzanti, L, Torrente, I, Marino, B, Digilio, MC, Zampino, G, Ackerman, MJ, Dallapiccola, B, Tartaglia, M, Gelb, BD	Nat Genet	2007

External Reference Information

External Reference

UniProt:P04049 RAF1

Gene Names

RAF1, RAF

Chain

chain:1-648

Reference Genes

BioGPS Gene:5894 RAF1

COSMIC (genes):RAF1 RAF1

CTD Gene:5894 RAF1

dbSNP Gene:5894 RAF1

ENSEMBL:ENSG00000132155 RAF1

HGNC:9829 RAF1

KEGG Gene (Homo sapiens):5894 RAF1

Monarch:5894 RAF1

NCBI Gene:5894 RAF1

OMIM:164760 RAF1

UCSC:P04049 RAF1

Reference Transcript

Other Identifiers

11716472_a_at

11748273_a_at

16950848

1917_at

201244_s_at

2663243

2663245

2663246

2663247

2663248

2663251

2663253

2663258

2663261

2663263

2663270

2663271

2663272

2663273

2663274

2663275

2663278

2663279

2663280

2663281

2663282

2663283

2663284

2663292

38742_s_at

38743_f_at

5894

8085374

A_23_P40952

GE59649

GO:0000165

GO:0000166

GO:0000186

GO:0001666

GO:0001678

GO:0001934

GO:0002223

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005794

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006810

GO:0006915

GO:0006950

GO:0007010

GO:0007165

GO:0007190

GO:0007267

GO:0007507

GO:0008150

GO:0008179

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0010856

GO:0015031

GO:0016020

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0017016

GO:0019899

GO:0022607

GO:0030154

GO:0030168

GO:0030234

GO:0030878

GO:0031143

GO:0031333

GO:0031434

GO:0033138

GO:0034220

GO:0034641

GO:0035019

GO:0035023

GO:0035556

GO:0035773

GO:0035994

GO:0040011

GO:0042060

GO:0042592

GO:0042802

GO:0042981

GO:0043066

GO:0043085

GO:0043154

GO:0043167

GO:0043226

GO:0044877

GO:0045104

GO:0045595

GO:0045944

GO:0046872

GO:0048011

GO:0048538

GO:0048856

GO:0048870

GO:0055085

GO:0060324

GO:0065003

GO:0071550

GO:1902042

GO:2000145

ILMN_1813489

PH_hs_0039978

TC03001174.hg

X03484_at

g4506400_3p_a_at

Participant Of

hasMember

activated RAF1 CR2 mutants [cytosol]

Other forms of this molecule

RAF1 [cytosol]

p-S338,Y340,Y341-RAF1 [cytosol]

p-S338-RAF1 [cytosol]

p-S621-RAF1 S259F [cytosol]

p-S621-RAF1 S257L [cytosol]

p-S621-RAF1 P261L [cytosol]

p-S621-RAF1 N262K [cytosol]

p-S621-RAF1 P261A [cytosol]

p-S621-RAF1 P261S [cytosol]

p-S621-RAF1 S259T [cytosol]

p-S621-RAF1 P261T [cytosol]

p-S621-RAF1 P261R [cytosol]

p-S621-RAF1 S259P [cytosol]

p-S621-RAF1 T260I [cytosol]

p-S621-RAF1 T260R [cytosol]

p-S621-RAF1 V263A [cytosol]

p-S621-RAF1 R256S [cytosol]

p-S621-RAF1 T491I [cytosol]

p-S621-RAF1 D486N [cytosol]

p-S621-RAF1 S427G [cytosol]

p-S621-RAF1 L613V [cytosol]

p-S621-RAF1 G361A [cytosol]

p-S621-RAF1 G370R [cytosol]

p-S621-RAF1 D486G [cytosol]

p-S621-RAF1 T491R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]

p-S338,Y341,S494,S621-RAF1 T491I [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]

p-S338,Y341,S494,S621 RAF1 T491R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]

hyperphosphorylated RAF1 [plasma membrane]

p-S621-RAF1 [plasma membrane]

p-Y341,T491,S494,S621 RAF1 [plasma membrane]

p-S259,S621-RAF1 [cytosol]

p-S621-RAF1 [cytosol]

p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]

p-S338,Y341,T491,S494,S621 RAF1 [cytosol]

Modified Residues

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

L-proline 261 replaced with L-leucine

Coordinate

261

PsiMod

L-proline removal [MOD:01645]

A protein modification that effectively removes or replaces an L-proline.

L-leucine residue [MOD:00020]

A protein modification that effectively converts a source amino acid residue to an L-leucine.

Name

O-phospho-L-serine at 338

Coordinate

338

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 341

Coordinate

341

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 491

Coordinate

491

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 494

Coordinate

494

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
melanoma	1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Costello syndrome	0050469	Faciocutaneoskeletal Syndrome, FCS SYNDROME
Noonan syndrome	3490	Turner's phenotype, karyotype normal (disorder)
hypertrophic cardiomyopathy	11984	familial hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy

Cross References

RefSeq

XP_011532276.1, NP_002871.1, XP_005265412.1

ZINC - World Drugs

RAF1_HUMAN

ClinGen

CA267618

OpenTargets

ENSG00000132155

ZINC - FDA approved

RAF1_HUMAN

ZINC - Substances

RAF1_HUMAN

ZINC target

P04049

ZINC - Biogenic

RAF1_HUMAN

PRO

P04049

PDB

1FAQ, 4G0N, 3IQU, 3KUD, 3KUC, 4FJ3, 4G3X, 4IEA, 3O8I, 6PTS, 3OMV, 6NTC, 1C1Y, 1GUA, 1RFA, 3IQJ, 3CU8, 6PTW, 3NKX, 4IHL, 6NTD, 3IQV, 1FAR

ZINC - Investigational

RAF1_HUMAN

COSMIC

COSM5398076

GeneCards

P04049

HPA

ENSG00000132155-RAF1

Ensembl

ENST00000442415, ENSP00000401888, ENSG00000132155, ENSP00000251849, ENST00000251849

Orphanet

16828

ZINC - Predictions - Purchasable

RAF1_HUMAN

HMDB Protein

HMDBP01153

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	23	HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912)	0.975	25
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF [cytosol] (R-HSA-167224) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.959	57
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.957	18
UniProt:Q02750 MAP2K1	27	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 F53C [cytosol] (R-HSA-9652028) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 [cytosol] (R-HSA-59502) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.955	37
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.934	20
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.864	9
UniProt:P01111 NRAS	25	NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS Q60E [plasma membrane] (R-HSA-9656589) S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) proNRAS [cytosol] (R-HSA-9647758) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS [plasma membrane] (R-HSA-62725)	0.861	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.848	7
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.811	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.802	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.773	6
UniProt:P30086 PEBP1	1	PEBP1 [cytosol] (R-HSA-61487)	0.758	10
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.758	5
UniProt:P36507 MAP2K2	12	MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089)	0.745	5
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.744	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.738	5
UniProt:P01116-2 KRAS	8	pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane] (R-HSA-9653578) S-Farn-Me KRAS4B [cytosol] (R-HSA-9654510) pro-KRAS4B [cytosol] (R-HSA-9649686) S-Farn proKRAS4B [endoplasmic reticulum membrane] (R-HSA-9649693) S-Farn KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649698) S-Farn-Me KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649690) pS181-S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9653482) S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9647815)	0.676	3
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.659	6
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(1-491) [cytosol] (R-HSA-2028280)	0.645	6
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:O43852 CALU	3	p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [endoplasmic reticulum lumen] (R-HSA-350695) CALU [extracellular region] (R-HSA-350739)	0.643	4
UniProt:P01116 KRAS	47	KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361) KRAS G12S [plasma membrane] (R-HSA-9649629) KRAS Q61L [plasma membrane] (R-HSA-9649653) KRAS Q61K [plasma membrane] (R-HSA-9649648) KRAS Q61R [plasma membrane] (R-HSA-9649650) KRAS F156L [plasma membrane] (R-HSA-9651372) KRAS G12C [plasma membrane] (R-HSA-6802331) KRAS L19F [plasma membrane] (R-HSA-9653097) KRAS G12D [plasma membrane] (R-HSA-6802333) KRAS Q22E [plasma membrane] (R-HSA-9651364) KRAS K117N [plasma membrane] (R-HSA-9653095) KRAS Q22R [plasma membrane] (R-HSA-9651367) KRAS Q61H [plasma membrane] (R-HSA-6802434) KRAS V14I [plasma membrane] (R-HSA-6802480) KRAS G12V [plasma membrane] (R-HSA-6802354) KRAS D153V [plasma membrane] (R-HSA-6802292) KRAS G13D [plasma membrane] (R-HSA-6802359) KRAS T58I [plasma membrane] (R-HSA-6802472) KRAS G60R [plasma membrane] (R-HSA-9651359) KRAS D33E [plasma membrane] (R-HSA-9653083) KRAS Q22K [plasma membrane] (R-HSA-9653100) KRAS G60V [plasma membrane] (R-HSA-9653092) KRAS G60D [plasma membrane] (R-HSA-9653088) KRAS E63K [plasma membrane] (R-HSA-9653085) KRAS A59T [plasma membrane] (R-HSA-9653079) KRAS [plasma membrane] (R-HSA-62719) proKRAS [cytosol] (R-HSA-9647762) S-Farn-proKRAS [endoplasmic reticulum membrane] (R-HSA-9647925) S-Farn-Me KRAS [endoplasmic reticulum membrane] (R-HSA-9647801) S-Farn-KRAS [endoplasmic reticulum membrane] (R-HSA-9647790)	0.623	5
UniProt:P62834 RAP1A	4	RAP1A [cytosol] (R-HSA-169884) RAP1A [specific granule membrane] (R-HSA-6806137) RAP1A [plasma membrane] (R-HSA-354118) RAP1A [endosome membrane] (R-HSA-190053)	0.623	2
UniProt:Q96S96 PEBP4			0.597	4
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297)	0.589	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.589	2
UniProt:Q6TCH7 PAQR3	1	PAQR3 [Golgi membrane] (R-HSA-5674103)	0.576	3
UniProt:P11021 HSPA5	6	HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.576	5
UniProt:P32883 Kras	12	Kras [cytosol] (R-MMU-9654510) Kras [Golgi membrane] (R-MMU-9647903) phospho-Kras [mitochondrial outer membrane] (R-MMU-9653578) Kras [cytosol] (R-MMU-9647762) Kras [cytosol] (R-MMU-9649683) Kras [endoplasmic reticulum membrane] (R-MMU-9647925) Kras [endoplasmic reticulum membrane] (R-MMU-9647790) Kras [endoplasmic reticulum membrane] (R-MMU-9647801) phospho-Kras [plasma membrane] (R-MMU-9653482) Kras [plasma membrane] (R-MMU-1250483) Kras [plasma membrane] (R-MMU-9647815) Kras [plasma membrane] (R-MMU-9647915)	0.573	2
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.564	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.564	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.564	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709)	0.558	2
UniProt:O39474 O39474			0.556	4
UniProt:Q14790 CASP8	8	CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(217-374) [cytosol] (R-HSA-75975)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.547	5
UniProt:Q13362 PPP2R5C	3	PPP2R5C [nucleoplasm] (R-HSA-3008946) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954)	0.544	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.544	2
UniProt:P50990 CCT8	5	CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.527	3
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.527	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.527	3
UniProt:P03495 NS1			0.508	2
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.508	2
UniProt:P43246 MSH2	3	MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.508	2
UniProt:P28301	3	Lox [extracellular region] (R-MMU-2022071) Lox [extracellular region] (R-MMU-2022074) Lox [extracellular region] (R-MMU-2022085)	0.499	2
UniProt:Q9ESN9-2 MAPK8IP3			0.499	2
UniProt:P01120	3	RAS2 [cytosol] (R-SCE-8873705-2) RAS2 [cytosol] (R-SCE-8874032-2) RAS2 [plasma membrane] (R-SCE-396959-2)	0.499	2
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.488	5

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