Reactome | p-S621-RAF1 D486N [cytosol]

p-S621-RAF1 D486N [cytosol]

Stable Identifier

R-HSA-9656088

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf

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Literature References

PubMed ID	Title	Journal	Year
22826437	Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants Kim, KH, Araki, T, Gu, S, Yin, J, Simpson, J, Neel, BG, Hong, JH, Wu, X, Backx, PH, Bayliss, P	Mol. Cell. Biol.	2012
17603483	Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy Ackerman, MJ, Marino, B, Zampino, G, Pennacchio, LA, Bos, JM, Martinelli, S, Gelb, BD, Mazzanti, L, Lepri, F, Faul, C, Rossi, C, López Siguero, JP, Esposito, G, Carta, C, Selicorni, A, Tenconi, R, Oishi, K, Pogna, EA, Torrente, I, Pandit, B, Dallapiccola, B, Mundel, P, Ustaszewska, A, Schackwitz, W, Sarkozy, A, Digilio, MC, Landstrom, A, Ommen, SR, Tartaglia, M	Nat Genet	2007

External Reference Information

External Reference

UniProt:P04049 RAF1

Gene Names

RAF1, RAF

Chain

chain:1-648

Reference Genes

BioGPS Gene:5894 RAF1

COSMIC (genes):RAF1 RAF1

CTD Gene:5894 RAF1

dbSNP Gene:5894 RAF1

ENSEMBL:ENSG00000132155 RAF1

HGNC:9829 RAF1

KEGG Gene (Homo sapiens):5894 RAF1

Monarch:5894 RAF1

NCBI Gene:5894 RAF1

OMIM:164760 RAF1

UCSC:P04049 RAF1

Reference Transcript

Other Identifiers

11716472_a_at

11748273_a_at

16950848

1917_at

201244_s_at

2663243

2663245

2663246

2663247

2663248

2663251

2663253

2663258

2663261

2663263

2663270

2663271

2663272

2663273

2663274

2663275

2663278

2663279

2663280

2663281

2663282

2663283

2663284

2663292

38742_s_at

38743_f_at

5894

8085374

A_23_P40952

GE59649

GO:0000165

GO:0000166

GO:0000186

GO:0001666

GO:0001678

GO:0001934

GO:0002223

GO:0002250

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005794

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006810

GO:0006915

GO:0006950

GO:0007010

GO:0007165

GO:0007190

GO:0007267

GO:0007507

GO:0008150

GO:0008179

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0010856

GO:0015031

GO:0016020

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0019899

GO:0022607

GO:0030154

GO:0030168

GO:0030234

GO:0030878

GO:0031143

GO:0031267

GO:0031333

GO:0031434

GO:0033138

GO:0034220

GO:0034641

GO:0035019

GO:0035023

GO:0035556

GO:0035773

GO:0035994

GO:0040011

GO:0042060

GO:0042592

GO:0042802

GO:0042981

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0044877

GO:0045104

GO:0045595

GO:0045944

GO:0046872

GO:0048011

GO:0048538

GO:0048856

GO:0048870

GO:0055085

GO:0060324

GO:0065003

GO:0071550

GO:0106310

GO:0106311

GO:1902042

GO:2000145

HMNXSV003010706

HMNXSV003037375

ILMN_1813489

PH_hs_0039978

TC03001174.hg

X03484_at

g4506400_3p_a_at

Participates

as a member of

p-S621 RAF1 CR3 mutants [cytosol] (Homo sapiens)

Other forms of this molecule

p-S338,Y340,Y341-RAF1 [cytosol]

p-S338-RAF1 [cytosol]

RAF1 [cytosol]

p-S621-RAF1 S259F [cytosol]

p-S621-RAF1 S257L [cytosol]

p-S621-RAF1 P261L [cytosol]

p-S621-RAF1 N262K [cytosol]

p-S621-RAF1 P261A [cytosol]

p-S621-RAF1 P261S [cytosol]

p-S621-RAF1 S259T [cytosol]

p-S621-RAF1 P261T [cytosol]

p-S621-RAF1 P261R [cytosol]

p-S621-RAF1 S259P [cytosol]

p-S621-RAF1 T260I [cytosol]

p-S621-RAF1 T260R [cytosol]

p-S621-RAF1 V263A [cytosol]

p-S621-RAF1 R256S [cytosol]

p-S621-RAF1 T491I [cytosol]

p-S621-RAF1 S427G [cytosol]

p-S621-RAF1 L613V [cytosol]

p-S621-RAF1 G361A [cytosol]

p-S621-RAF1 G370R [cytosol]

p-S621-RAF1 D486G [cytosol]

p-S621-RAF1 T491R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]

p-S338,Y341,S494,S621-RAF1 T491I [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]

p-S338,Y341,S494,S621 RAF1 T491R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]

hyperphosphorylated RAF1 [plasma membrane]

p-S621-RAF1 [plasma membrane]

p-Y341,T491,S494,S621 RAF1 [plasma membrane]

p-S259,S621-RAF1 [cytosol]

p-S621-RAF1 [cytosol]

p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]

p-S338,Y341,T491,S494,S621 RAF1 [cytosol]

Modified Residues

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

L-aspartic acid 486 replaced with L-asparagine

Coordinate

486

PsiMod

L-asparagine residue [MOD:00012]

A protein modification that effectively converts a source amino acid residue to an L-asparagine.

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

Disease

Name	Identifier	Synonyms
Noonan syndrome	DOID:3490	Turner's phenotype, karyotype normal (disorder)

Cross References

RefSeq

XP_011532276.1, NP_002871.1, XP_005265412.1

ZINC - World Drugs

RAF1_HUMAN

Guide to Pharmacology - Targets

2184

ClinGen

CA341928

OpenTargets

ENSG00000132155

ZINC - FDA approved

RAF1_HUMAN

ZINC - Substances

RAF1_HUMAN

ZINC target

P04049

ZINC - Biogenic

RAF1_HUMAN

PRO

P04049

GlyGen

P04049

PDB

3IQV, 3KUD, 1RFA, 3CU8, 1GUA, 4IHL, 6XHB, 6NTC, 6XHA, 6NTD, 7JHP, 6XGV, 3KUC, 3OMV, 4G3X, 6VJJ, 3IQU, 1C1Y, 3IQJ, 4IEA, 6PTW, 6XGU, 6XI7, 6PTS, 3NKX, 4G0N, 3O8I, 4FJ3, 1FAQ, 1FAR

ZINC - Investigational

RAF1_HUMAN

GeneCards

P04049

HPA

ENSG00000132155-RAF1

Ensembl

ENST00000442415, ENSP00000401888, ENSP00000251849, ENSG00000132155, ENST00000251849

Pharos - Targets

P04049

ZINC - Predictions - Purchasable

RAF1_HUMAN

Orphanet

16828

HMDB Protein

HMDBP01153

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS [plasma membrane] (R-HSA-62717) HRAS Q61L [plasma membrane] (R-HSA-6802452) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) HRAS G12S [plasma membrane] (R-HSA-6802343) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS K117R [plasma membrane] (R-HSA-9656010)	0.976	26
UniProt:P15056 BRAF	20	BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF E501G [cytosol] (R-HSA-9651132) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF D594N [cytosol] (R-HSA-6802299) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L505H [cytosol] (R-HSA-9648845) BRAF D594G [cytosol] (R-HSA-6802295) BRAF E586K [cytosol] (R-HSA-6802308) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF N581D [cytosol] (R-HSA-9651152) BRAF G464E [cytosol] (R-HSA-6802369) BRAF L597V [cytosol] (R-HSA-6802397) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469V [cytosol] (R-HSA-9648620) BRAF D638E [cytosol] (R-HSA-9651125) BRAF A246P [cytosol] (R-HSA-9651123) BRAF V600K [cytosol] (R-HSA-6802502) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305)	0.959	57
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.957	18
UniProt:Q02750 MAP2K1	20	MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 P124S [cytosol] (R-HSA-9652062)	0.955	37
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.934	20
UniProt:P01111 NRAS	20	NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS [plasma membrane] (R-HSA-62725) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS Q61R [plasma membrane] (R-HSA-6802461) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS Q61L [plasma membrane] (R-HSA-6802455) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893)	0.895	9
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.864	9
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.848	7
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.811	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.802	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.773	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.758	5
UniProt:P30086 PEBP1	1	PEBP1 [cytosol] (R-HSA-61487)	0.758	10
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 [cytosol] (R-HSA-59504)	0.745	5
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.744	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.738	5
UniProt:P01116 KRAS	20	KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS K5N [plasma membrane] (R-HSA-9651361) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS A146S [plasma membrane] (R-HSA-9649621) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS G12A [plasma membrane] (R-HSA-9649088) S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS P34L [plasma membrane] (R-HSA-9651269)	0.695	6
UniProt:P01116-2 KRAS	8	S-Farn KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649698) S-Farn-Me KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649690) S-Farn proKRAS4B [endoplasmic reticulum membrane] (R-HSA-9649693) pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane] (R-HSA-9653578) S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9647815) pro-KRAS4B [cytosol] (R-HSA-9649686) S-Farn-Me KRAS4B [cytosol] (R-HSA-9654510) pS181-S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9653482)	0.676	3
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.659	6
UniProt:Q13188 STK3	4	p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280)	0.645	6
UniProt:O43852 CALU	3	CALU [extracellular region] (R-HSA-350739) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [endoplasmic reticulum lumen] (R-HSA-350695)	0.643	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P62834 RAP1A	4	RAP1A [specific granule membrane] (R-HSA-6806137) RAP1A [endosome membrane] (R-HSA-190053) RAP1A [cytosol] (R-HSA-169884) RAP1A [plasma membrane] (R-HSA-354118)	0.623	2
UniProt:Q96S96 PEBP4			0.597	4
UniProt:P11021 HSPA5	6	HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322)	0.576	5
UniProt:Q6TCH7 PAQR3	1	PAQR3 [Golgi membrane] (R-HSA-5674103)	0.576	3
UniProt:P32883 Kras	14	Kras [Golgi membrane] (R-MMU-9647903) Kras [plasma membrane] (R-MMU-1250483) Kras [plasma membrane] (R-MMU-9674814) phospho-Kras [mitochondrial outer membrane] (R-MMU-9653578) Kras [cytosol] (R-MMU-9649683) phospho-Kras [plasma membrane] (R-MMU-9674821) Kras [plasma membrane] (R-MMU-9647815) Kras [cytosol] (R-MMU-9654510) Kras [endoplasmic reticulum membrane] (R-MMU-9647925) Kras [plasma membrane] (R-MMU-9647915) Kras [endoplasmic reticulum membrane] (R-MMU-9647801) Kras [cytosol] (R-MMU-9647762) phospho-Kras [plasma membrane] (R-MMU-9653482) Kras [endoplasmic reticulum membrane] (R-MMU-9647790)	0.573	2
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.564	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [nucleoplasm] (R-HSA-5082401)	0.564	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.564	2
UniProt:Q13177 PAK2	11	p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2 [cytosol] (R-HSA-211604) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2(213-524) [cytosol] (R-HSA-211653) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705)	0.558	2
UniProt:O39474 O39474			0.556	4
UniProt:Q14790 CASP8	8	CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [cytosol] (R-HSA-76158)	0.556	3
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.553	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.547	5
UniProt:Q13362 PPP2R5C	3	p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954) PPP2R5C [nucleoplasm] (R-HSA-3008946)	0.544	2
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.544	2
UniProt:P31749 AKT1	13	AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252)	0.536	2
UniProt:P50990 CCT8	5	CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [cytosol] (R-HSA-390449) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [azurophil granule lumen] (R-HSA-6799369)	0.527	3
UniProt:P50402 EMD	4	EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endosome membrane] (R-HSA-9715092)	0.527	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646)	0.527	3
UniProt:P03495 NS1			0.508	2
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.508	2
UniProt:P43246 MSH2	3	MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.508	2
UniProt:P28301	3	Lox [extracellular region] (R-MMU-2022085) Lox [extracellular region] (R-MMU-2022071) Lox [extracellular region] (R-MMU-2022074)	0.499	2
UniProt:Q9ESN9-2 MAPK8IP3			0.499	2
UniProt:P01120	2	RAS2 [plasma membrane] (R-SCE-396959-2) RAS2 [plasma membrane] (R-SCE-9715189)	0.499	2
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.488	5

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