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p-S621-RAF1 S259T [cytosol]
Stable Identifier
R-HSA-9656130
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)
p-S621 RAF1 CR2 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 S259T [cytosol] (Homo sapiens)
Phosphorylation of RAF1 mutants (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
RAF1 mutants [cytosol] (Homo sapiens)
p-S621 RAF1 CR2 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 S259T [cytosol] (Homo sapiens)
RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)
RAF1 mutants [cytosol] (Homo sapiens)
p-S621 RAF1 CR2 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 S259T [cytosol] (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
RAF1 mutants [cytosol] (Homo sapiens)
p-S621 RAF1 CR2 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 S259T [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21784453
Spectrum of mutations in Noonan syndrome and their correlation with phenotypes
Lee, BH
,
Kim, JM
,
Jin, HY
,
Kim, GH
,
Choi, JH
,
Yoo, HW
J. Pediatr.
2011
External Reference Information
External Reference
UniProt:P04049 RAF1
Gene Names
RAF1, RAF
Chain
chain:1-648
Reference Genes
BioGPS Gene:5894 RAF1
COSMIC (genes):RAF1 RAF1
CTD Gene:5894 RAF1
dbSNP Gene:5894 RAF1
ENSEMBL:ENSG00000132155 RAF1
HGNC:9829 RAF1
KEGG Gene (Homo sapiens):5894 RAF1
Monarch:5894 RAF1
NCBI Gene:5894 RAF1
OMIM:164760 RAF1
UCSC:P04049 RAF1
Reference Transcript
RefSeq:NM_002880.3 RAF1
RefSeq:XM_005265355.2 RAF1
RefSeq:XM_011533974.2 RAF1
Other Identifiers
11716472_a_at
11748273_a_at
16950848
1917_at
201244_s_at
2663243
2663245
2663246
2663247
2663248
2663251
2663253
2663258
2663261
2663263
2663270
2663271
2663272
2663273
2663274
2663275
2663278
2663279
2663280
2663281
2663282
2663283
2663284
2663292
38742_s_at
38743_f_at
5894
8085374
A_23_P40952
GE59649
GO:0000165
GO:0000166
GO:0000186
GO:0001666
GO:0001678
GO:0001934
GO:0002223
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005794
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006950
GO:0007010
GO:0007165
GO:0007190
GO:0007267
GO:0007507
GO:0008150
GO:0008179
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0010856
GO:0015031
GO:0016020
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0019899
GO:0022607
GO:0030154
GO:0030168
GO:0030234
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0031434
GO:0033138
GO:0034220
GO:0034641
GO:0035019
GO:0035023
GO:0035556
GO:0035773
GO:0035994
GO:0040011
GO:0042060
GO:0042592
GO:0042802
GO:0042981
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0044877
GO:0045104
GO:0045595
GO:0045944
GO:0046872
GO:0048011
GO:0048538
GO:0048856
GO:0048870
GO:0050790
GO:0055085
GO:0060324
GO:0065003
GO:0071550
GO:0106310
GO:0106311
GO:1902042
GO:2000145
HMNXSV003010706
HMNXSV003037375
ILMN_1813489
PH_hs_0039978
TC03001174.hg
X03484_at
g4506400_3p_a_at
Participates
as a member of
p-S621 RAF1 CR2 mutants [cytosol] (Homo sapiens)
Other forms of this molecule
p-S621-RAF1 S259F [cytosol]
p-S621-RAF1 S257L [cytosol]
p-S621-RAF1 P261L [cytosol]
p-S621-RAF1 N262K [cytosol]
p-S621-RAF1 P261A [cytosol]
p-S621-RAF1 P261S [cytosol]
p-S621-RAF1 P261T [cytosol]
p-S621-RAF1 P261R [cytosol]
p-S621-RAF1 S259P [cytosol]
p-S621-RAF1 T260I [cytosol]
p-S621-RAF1 T260R [cytosol]
p-S621-RAF1 V263A [cytosol]
p-S621-RAF1 R256S [cytosol]
p-S621-RAF1 T491I [cytosol]
p-S621-RAF1 D486N [cytosol]
p-S621-RAF1 S427G [cytosol]
p-S621-RAF1 L613V [cytosol]
p-S621-RAF1 G361A [cytosol]
p-S621-RAF1 G370R [cytosol]
p-S621-RAF1 D486G [cytosol]
p-S621-RAF1 T491R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
RAF1 [cytosol]
p-S338,Y340,Y341-RAF1 [cytosol]
p-S338-RAF1 [cytosol]
p-S621-RAF1 [plasma membrane]
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
p-S259,S621-RAF1 [cytosol]
hyperphosphorylated RAF1 [plasma membrane]
p-S621-RAF1 [cytosol]
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
Modified Residues
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
L-serine 259 replaced with L-threonine
Coordinate
259
PsiMod
L-threonine residue [MOD:00026]
A protein modification that effectively converts a source amino acid residue to L-threonine.
L-serine removal [MOD:01646]
A protein modification that effectively removes or replaces an L-serine.
Disease
Name
Identifier
Synonyms
Noonan syndrome
DOID:3490
Turner's phenotype, karyotype normal (disorder)
Cross References
RefSeq
XP_005265412.1
,
NP_002871.1
,
XP_011532276.1
ZINC - World Drugs
RAF1_HUMAN
ClinGen
CA261617
OpenTargets
ENSG00000132155
ZINC - FDA approved
RAF1_HUMAN
ZINC - Substances
RAF1_HUMAN
ZINC - Biogenic
RAF1_HUMAN
ZINC target
P04049
PRO
P04049
PDB
6NTC
,
3KUC
,
6PTS
,
3IQU
,
4G3X
,
1FAQ
,
4IEA
,
3KUD
,
3OMV
,
3O8I
,
7JHP
,
4FJ3
,
3CU8
,
1GUA
,
3IQV
,
6PTW
,
3IQJ
,
1C1Y
,
4G0N
,
1RFA
,
4IHL
,
6NTD
,
3NKX
,
1FAR
ZINC - Investigational
RAF1_HUMAN
GeneCards
P04049
HPA
ENSG00000132155-RAF1
Ensembl
ENSP00000251849
,
ENSG00000132155
,
ENSP00000401888
,
ENST00000442415
,
ENST00000251849
Orphanet
16828
ZINC - Predictions - Purchasable
RAF1_HUMAN
HMDB Protein
HMDBP01153
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01112 HRAS
23
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
0.975
25
UniProt:P15056 BRAF
68
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
BRAF [cytosol]
(R-HSA-167224)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.959
57
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.957
18
UniProt:Q02750 MAP2K1
27
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 E44_E57del [cytosol]
(R-HSA-9652026)
MAP2K1 P124Q [cytosol]
(R-HSA-9652058)
MAP2K1 F53C [cytosol]
(R-HSA-9652028)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
MAP2K1 [cytosol]
(R-HSA-59502)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
0.955
37
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.934
20
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.864
9
UniProt:P01111 NRAS
25
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
S-Farn-Me PalmS NRAS [plasma membrane]
(R-HSA-9647910)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn NRAS [endoplasmic reticulum membrane]
(R-HSA-9647782)
S-Farn-Me NRAS [endoplasmic reticulum membrane]
(R-HSA-9647891)
S-Farn-proNRAS [endoplasmic reticulum membrane]
(R-HSA-9647928)
proNRAS [cytosol]
(R-HSA-9647758)
0.861
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.848
7
UniProt:P04049 RAF1
54
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
RAF1 [cytosol]
(R-HSA-167205)
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.811
6
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.802
6
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.773
6
UniProt:P30086 PEBP1
1
PEBP1 [cytosol]
(R-HSA-61487)
0.758
10
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.758
5
UniProt:P36507 MAP2K2
12
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
0.745
5
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.744
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.738
5
UniProt:P01116-2 KRAS
8
S-Farn-Me KRAS4B [cytosol]
(R-HSA-9654510)
pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-HSA-9653578)
pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-HSA-9653482)
pro-KRAS4B [cytosol]
(R-HSA-9649686)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649693)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649698)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649690)
S-Farn-Me KRAS4B [plasma membrane]
(R-HSA-9647815)
0.676
3
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.659
6
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
STK3(1-491) [cytosol]
(R-HSA-2028280)
0.645
6
UniProt:O43852 CALU
3
p-CALU [endoplasmic reticulum lumen]
(R-HSA-8956931)
CALU [endoplasmic reticulum lumen]
(R-HSA-350695)
CALU [extracellular region]
(R-HSA-350739)
0.643
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P01116 KRAS
49
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
KRAS G12S [plasma membrane]
(R-HSA-9649629)
KRAS Q61L [plasma membrane]
(R-HSA-9649653)
KRAS Q61K [plasma membrane]
(R-HSA-9649648)
KRAS Q61R [plasma membrane]
(R-HSA-9649650)
KRAS F156L [plasma membrane]
(R-HSA-9651372)
KRAS G12C [plasma membrane]
(R-HSA-6802331)
KRAS L19F [plasma membrane]
(R-HSA-9653097)
KRAS G12D [plasma membrane]
(R-HSA-6802333)
KRAS Q22E [plasma membrane]
(R-HSA-9651364)
KRAS K117N [plasma membrane]
(R-HSA-9653095)
KRAS Q22R [plasma membrane]
(R-HSA-9651367)
KRAS Q61H [plasma membrane]
(R-HSA-6802434)
KRAS V14I [plasma membrane]
(R-HSA-6802480)
KRAS G12V [plasma membrane]
(R-HSA-6802354)
KRAS D153V [plasma membrane]
(R-HSA-6802292)
KRAS G13D [plasma membrane]
(R-HSA-6802359)
KRAS T58I [plasma membrane]
(R-HSA-6802472)
KRAS G60R [plasma membrane]
(R-HSA-9651359)
KRAS D33E [plasma membrane]
(R-HSA-9653083)
KRAS Q22K [plasma membrane]
(R-HSA-9653100)
KRAS G60V [plasma membrane]
(R-HSA-9653092)
KRAS G60D [plasma membrane]
(R-HSA-9653088)
KRAS E63K [plasma membrane]
(R-HSA-9653085)
KRAS A59T [plasma membrane]
(R-HSA-9653079)
proKRAS [cytosol]
(R-HSA-9647762)
S-Farn-proKRAS [endoplasmic reticulum membrane]
(R-HSA-9647925)
S-Farn-Me KRAS [endoplasmic reticulum membrane]
(R-HSA-9647801)
S-Farn-KRAS [endoplasmic reticulum membrane]
(R-HSA-9647790)
KRAS [plasma membrane]
(R-HSA-62719)
0.623
5
UniProt:P62834 RAP1A
4
RAP1A [cytosol]
(R-HSA-169884)
RAP1A [specific granule membrane]
(R-HSA-6806137)
RAP1A [endosome membrane]
(R-HSA-190053)
RAP1A [plasma membrane]
(R-HSA-354118)
0.623
2
UniProt:Q96S96 PEBP4
0.597
4
UniProt:Q6TCH7 PAQR3
1
PAQR3 [Golgi membrane]
(R-HSA-5674103)
0.576
3
UniProt:P11021 HSPA5
6
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.576
5
UniProt:P32883 Kras
14
phospho-Kras [plasma membrane]
(R-MMU-9674821)
Kras [plasma membrane]
(R-MMU-9674814)
phospho-Kras [mitochondrial outer membrane]
(R-MMU-9653578)
Kras [cytosol]
(R-MMU-9654510)
phospho-Kras [plasma membrane]
(R-MMU-9653482)
Kras [Golgi membrane]
(R-MMU-9647903)
Kras [cytosol]
(R-MMU-9647762)
Kras [cytosol]
(R-MMU-9649683)
Kras [endoplasmic reticulum membrane]
(R-MMU-9647925)
Kras [endoplasmic reticulum membrane]
(R-MMU-9647790)
Kras [endoplasmic reticulum membrane]
(R-MMU-9647801)
Kras [plasma membrane]
(R-MMU-1250483)
Kras [plasma membrane]
(R-MMU-9647915)
Kras [plasma membrane]
(R-MMU-9647815)
0.573
2
UniProt:O95816 BAG2
1
BAG2 [cytosol]
(R-HSA-5255445)
0.564
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.564
3
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.564
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
0.558
2
UniProt:Q14790 CASP8
8
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(217-374) [cytosol]
(R-HSA-75975)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O39474 O39474
0.556
4
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.547
5
UniProt:Q13362 PPP2R5C
3
p-S337-PPP2R5C [cytosol]
(R-HSA-6811447)
PPP2R5C [nucleoplasm]
(R-HSA-3008946)
PPP2R5C [cytosol]
(R-HSA-3008954)
0.544
2
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.544
2
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.536
2
UniProt:P50990 CCT8
5
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [cytosol]
(R-HSA-390449)
0.527
3
UniProt:P50402 EMD
4
EMD [cytosol]
(R-HSA-9613988)
EMD [nuclear envelope]
(R-HSA-201573)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.527
3
UniProt:P03495 NS1
0.508
2
UniProt:Q99933 BAG1
1
BAG1 [cytosol]
(R-HSA-5255443)
0.508
2
UniProt:P43246 MSH2
3
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
0.508
2
UniProt:P28301
3
Lox [extracellular region]
(R-MMU-2022071)
Lox [extracellular region]
(R-MMU-2022074)
Lox [extracellular region]
(R-MMU-2022085)
0.499
2
UniProt:Q9ESN9-2 MAPK8IP3
0.499
2
UniProt:P01120
2
RAS2 [plasma membrane]
(R-SCE-396959)
RAS2 [plasma membrane]
(R-SCE-9715189-2)
0.499
2
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.488
5
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