Defective Base Excision Repair Associated with OGG1

Stable Identifier
R-HSA-9656249
Type
Pathway
Species
Homo sapiens
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OGG1 is the main DNA glycosylase responsible for removal of 8-oxoguanine (8oxoG), the most frequent type of oxidative DNA damage, from DNA and initiation of the base excision repair (Klungland et al. 1999, Minowa et al. 2000). A frequent OGG1 polymorphism increases the risk of breast and lung cancer in affected individuals, and inactivating mutations in OGG1 have been reported in various cancer types and in Alzheimer's disease. Ogg1 knockout mice are predisposed to cancer. For review, please refer to Boiteux et al. 2017.

Literature References
PubMed ID Title Journal Year
27903453 Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N-glycosylases

Boiteux, S, Coste, F, Castaing, B

Free Radic. Biol. Med. 2017
10725358 Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

Minowa, O, Arai, T, Hirano, M, Monden, Y, Nakai, S, Fukuda, M, Itoh, M, Takano, H, Hippou, Y, Aburatani, H, Masumura, K, Nohmi, T, Nishimura, S, Noda, T

Proc. Natl. Acad. Sci. U.S.A. 2000
10557315 Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Klungland, A, Rosewell, I, Hollenbach, S, Larsen, E, Daly, G, Epe, B, Seeberg, E, Lindahl, T, Barnes, DE

Proc. Natl. Acad. Sci. U.S.A. 1999
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease
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