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What is Reactome ?
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FAQ
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HRAS G13D [plasma membrane]
Stable Identifier
R-HSA-9656572
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
RAS GTPase cycle mutants (Homo sapiens)
Signaling by RAS GAP mutants (Homo sapiens)
RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
RAS GAP mutants [plasma membrane] (Homo sapiens)
HRAS G13D [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01112 HRAS
Gene Names
HRAS, HRAS1
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3265 HRAS
COSMIC (genes):HRAS HRAS
CTD Gene:3265 HRAS
dbSNP Gene:3265 HRAS
ENSEMBL:ENSG00000174775 HRAS
ENSEMBL_homo_sapiens_GENE:ENSG00000174775.18 HRAS
ENSEMBL_homo_sapiens_GENE:ENSG00000276536.4 HRAS
HGNC:5173 HRAS
KEGG Gene (Homo sapiens):3265 HRAS
Monarch:3265 HRAS
NCBI Gene:3265 HRAS
OMIM:190020 HRAS
UCSC:P01112 HRAS
Reference Transcript
RefSeq:NM_001130442.2 HRAS
RefSeq:NM_176795.4 HRAS
RefSeq:NM_005343.3 HRAS
RefSeq:NM_001318054.1 HRAS
Other Identifiers
11733320_a_at
11744709_a_at
1590_s_at
16733952
212983_PM_at
212983_at
3265
3358091
3358092
3358093
3358094
3358096
3358097
3358098
3358099
3358100
3358103
35701_at
7945436
A_23_P98183
GE57461
GO:0000139
GO:0000165
GO:0000166
GO:0001934
GO:0002376
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006886
GO:0006897
GO:0006935
GO:0007010
GO:0007165
GO:0007166
GO:0007264
GO:0007265
GO:0008284
GO:0008285
GO:0008286
GO:0009887
GO:0010628
GO:0010629
GO:0010863
GO:0012501
GO:0014044
GO:0016020
GO:0016192
GO:0016787
GO:0019003
GO:0023052
GO:0030154
GO:0030335
GO:0032729
GO:0032956
GO:0034260
GO:0036211
GO:0042060
GO:0042088
GO:0042127
GO:0042552
GO:0042832
GO:0043226
GO:0043406
GO:0043410
GO:0043495
GO:0043524
GO:0043547
GO:0045944
GO:0046330
GO:0048144
GO:0048146
GO:0048169
GO:0048471
GO:0048856
GO:0048870
GO:0050679
GO:0050852
GO:0051402
GO:0051726
GO:0060090
GO:0060612
GO:0070374
GO:0071480
GO:0090303
GO:0090314
GO:0090398
GO:0090402
GO:0097193
GO:0098542
GO:0098696
GO:0098772
GO:0098978
GO:1900029
GO:1905360
GO:2000630
HMNXSV003016066
Hs.37003.0.S1_3p_at
Hs.37003.0.S1_3p_x_at
ILMN_1699798
ILMN_1773751
J00277_at
PH_hs_0031161
TC11001236.hg
V00574_s_at
Participates
as a candidate of
RAS GAP mutants [plasma membrane] (Homo sapiens)
Other forms of this molecule
HRAS Q61R [plasma membrane]
HRAS Q61L [plasma membrane]
HRAS Q61K [plasma membrane]
HRAS G13R [plasma membrane]
HRAS G12V [plasma membrane]
HRAS G12S [plasma membrane]
HRAS T58I [plasma membrane]
HRAS G13C [plasma membrane]
HRAS K117R [plasma membrane]
HRAS G13V [plasma membrane]
HRAS G13S [plasma membrane]
HRAS K117N [plasma membrane]
HRAS G12D [plasma membrane]
HRAS G12C [plasma membrane]
HRAS [plasma membrane]
S-Farn-Me HRAS [plasma membrane]
S-Farn-Me PalmS HRAS [Golgi membrane]
S-Farn-Me HRAS [endoplasmic reticulum membrane]
S-Farn-HRAS [endoplasmic reticulum membrane]
S-Farn-proHRAS [endoplasmic reticulum membrane]
proHRAS [cytosol]
S-Farn-Me-2xPalmS HRAS [plasma membrane]
Modified Residues
Name
glycine 13 replaced with L-aspartic acid
Coordinate
13
PsiMod
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
L-aspartic acid residue [MOD:00013]
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
Disease
Name
Identifier
Synonyms
melanoma
DOID:1909
Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
head and neck squamous cell carcinoma
DOID:5520
carcinoma of the head and neck, squamous cell carcinoma of the head and neck
Cross References
RefSeq
NP_001304983.1
,
NP_001123914.1
,
NP_005334.1
,
NP_789765.1
Guide to Pharmacology - Targets
2822
OpenTargets
ENSG00000174775
ZINC - Substances
RASH_HUMAN
ZINC target
P01112
PRO
P01112
PDB
1CTQ
,
6V9N
,
8BE8
,
3RSL
,
421P
,
4DLW
,
8CNN
,
7DPJ
,
4DLT
,
621P
,
6CUP
,
1AA9
,
3LBN
,
4DLS
,
4URX
,
2QUZ
,
1XCM
,
3RS7
,
4URW
,
1PLL
,
1IAQ
,
5E95
,
4L9W
,
5B2Z
,
2EVW
,
121P
,
7VV9
,
1AGP
,
5WFO
,
2CLC
,
4DLY
,
6BVK
,
1ZVQ
,
8ELU
,
5ZC6
,
3K8Y
,
6D5L
,
6V9F
,
1PLK
,
2RGC
,
6D5M
,
2RGD
,
6DZH
,
4Q21
,
6V9L
,
1JAI
,
2UZI
,
8EM0
,
3KKN
,
4DST
,
2CL7
,
1P2V
,
3RS5
,
8ELX
,
5WFR
,
7VVG
,
8FG3
,
5VBE
,
3K9L
,
7JHP
,
7OGD
,
6MQT
,
4RSG
,
5P21
,
7OGE
,
7OGA
,
3RRY
,
8BEA
,
1CRR
,
8ELW
,
7OGF
,
4URY
,
3OIW
,
221P
,
5WPL
,
1K8R
,
6D5H
,
3RS2
,
721P
,
7TAM
,
2LCF
,
3RSO
,
4G0N
,
1PLJ
,
821P
,
7JII
,
8ELT
,
7DPH
,
3L8Z
,
6ZJ0
,
1LF5
,
4URZ
,
6BVL
,
4DLV
,
8TBG
,
6NTD
,
4NYI
,
7JIF
,
7OG9
,
3L8Y
,
1LFD
,
1QRA
,
5WFQ
,
6AMB
,
3RRZ
,
6Q21
,
3I3S
,
1RVD
,
8ELZ
,
1P2U
,
6D55
,
2CLD
,
8CNJ
,
4DLX
,
6D56
,
5WDQ
,
6NTC
,
1HE8
,
1XD2
,
7L0F
,
2RGB
,
1CLU
,
6D59
,
1CRQ
,
4US1
,
6CUO
,
6ZL3
,
7OGB
,
8ELV
,
5WDO
,
3LBI
,
4DLU
,
7JIG
,
3TGP
,
6V94
,
2RGA
,
1NVX
,
8BOS
,
7VV8
,
4DLR
,
3DDC
,
5X9S
,
6CUR
,
1JAH
,
1GNR
,
6BVJ
,
3LBH
,
8ELS
,
4URU
,
6D5J
,
4XVQ
,
2RGG
,
6V9O
,
4NYM
,
4L9S
,
2X1V
,
4G3X
,
8ELK
,
8BWG
,
4K81
,
6AXG
,
4DSU
,
2LWI
,
2CE2
,
6V9J
,
4NYJ
,
1NVW
,
3K9N
,
6D5E
,
4US0
,
6BVM
,
2CL6
,
6D5G
,
3OIV
,
3OIU
,
3RS4
,
6V9M
,
1P2T
,
4DLZ
,
3KKM
,
3RS3
,
2CL0
,
8BE7
,
521P
,
1BKD
,
2Q21
,
2RGE
,
4US2
,
1P2S
,
8FG4
,
5WDP
,
8BE9
,
1LF0
,
2N42
,
5VBZ
,
3LO5
,
2N46
,
4EFN
,
4EFM
,
6D5V
,
7L0G
,
2C5L
,
6D5W
,
1CRP
,
1XJ0
,
7OGC
,
1ZW6
,
3KUD
,
4EFL
,
1IOZ
,
1GNQ
,
6BVI
,
8ELR
,
4URV
,
7JIH
,
5B30
,
5WFP
,
3RS0
,
4XVR
,
6E6C
,
1GNP
,
1WQ1
,
6E6P
,
8ELY
,
2VH5
,
1NVU
,
8BE6
,
1NVV
,
1Q21
ZINC - Investigational
RASH_HUMAN
COSMIC
COSV54237021
IntEnz
3.6.5.2
GeneCards
P01112
HPA
ENSG00000174775-HRAS
Ensembl
ENSG00000174775
,
ENSP00000488225
,
ENST00000493230
,
ENSP00000488296
,
ENST00000311189
,
ENST00000451590
,
ENST00000417302
,
ENSP00000407586
,
ENSP00000388246
,
ENSP00000380723
,
ENST00000397596
,
ENSP00000434023
,
ENST00000615062
,
ENST00000610977
,
ENSP00000482366
,
ENSG00000276536
,
ENSP00000488757
,
ENSP00000480317
,
ENSP00000309845
,
ENST00000616241
,
ENSP00000480686
,
ENST00000631967
,
ENST00000631404
,
ENST00000634098
Pharos - Targets
P01112
ZINC - Predictions - Purchasable
RASH_HUMAN
Orphanet
16221
HMDB Protein
HMDBP01958
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.978
30
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.938
11
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.904
8
UniProt:Q9NZL6 RGL1
1
RGL1 [cytosol]
(R-HSA-561160)
0.744
4
UniProt:Q12967 RALGDS
1
RALGDS [cytosol]
(R-HSA-171001)
0.683
3
UniProt:Q8WUX9 CHMP7
2
CHMP7 [cytosol]
(R-HSA-917703)
CHMP7 [endosome membrane]
(R-HSA-9631168)
0.659
4
UniProt:P21359 NF1
20
NF1 R816* [cytosol]
(R-HSA-6802424)
NF1 F1464L [cytosol]
(R-HSA-6802410)
NF1 K1444E [cytosol]
(R-HSA-6802414)
NF1 L1187I [cytosol]
(R-HSA-6802417)
NF1 R1276P [cytosol]
(R-HSA-6802420)
NF1 R1412S [cytosol]
(R-HSA-6802421)
NF1 R2517* [cytosol]
(R-HSA-9647532)
NF1 Q616Gfs*4 [cytosol]
(R-HSA-9647468)
NF1 R2450* [cytosol]
(R-HSA-9647535)
NF1 R2637* [cytosol]
(R-HSA-9647529)
NF1 R2637Q [cytosol]
(R-HSA-9647525)
NF1 R304* [cytosol]
(R-HSA-9647522)
NF1 R1276* [cytosol]
(R-HSA-9647550)
NF1 C845Vfs*33 [cytosol]
(R-HSA-9647486)
NF1 E133Nfs*32 [cytosol]
(R-HSA-9647480)
NF1 R1276Q [cytosol]
(R-HSA-9647545)
NF1 R1276L [cytosol]
(R-HSA-9647547)
NF1 C324* [cytosol]
(R-HSA-9647483)
NF1 A131Vfs*19 [cytosol]
(R-HSA-9647476)
NF1 R1534* [cytosol]
(R-HSA-9647542)
0.604
3
UniProt:P42337 Pik3ca
1
Pik3ca [cytosol]
(R-MMU-9027214)
0.589
3
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.581
9
UniProt:P11233 RALA
2
RALA [cytosol]
(R-HSA-170988)
GGC-RALA [cytoplasmic vesicle membrane]
(R-HSA-1458479)
0.571
2
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.571
2
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.556
3
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.556
3
UniProt:O95674 CDS2
1
CDS2 [mitochondrial inner membrane]
(R-HSA-1498755)
0.556
3
UniProt:Q8N5V2 NGEF
2
NGEF [cytosol]
(R-HSA-3006800)
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [cytosol]
(R-HSA-3006405)
ITGB3BP [nucleoplasm]
(R-HSA-606325)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
0.556
3
UniProt:Q9EQZ6
1
RAPGEF4 [plasma membrane]
(R-MMU-3008666)
0.556
3
UniProt:A0AVK6 E2F8
1
E2F8 [nucleoplasm]
(R-HSA-8952990)
0.556
3
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.556
3
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.556
3
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.556
3
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
3
UniProt:Q7Z569 BRAP
2
ub-BRAP [cytosol]
(R-HSA-5674001)
BRAP [cytosol]
(R-HSA-5672938)
0.524
3
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.508
2
UniProt:Q16850 CYP51A1
1
CYP51A1 [endoplasmic reticulum membrane]
(R-HSA-194721)
0.483
2
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.462
2
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