Reactome | PolyUb-Misfolded ARL13B [late endosome lumen]

PolyUb-Misfolded ARL13B [late endosome lumen]

Stable Identifier

R-HSA-9659986

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

late endosome lumen

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Late endosomal microautophagy (Homo sapiens)
  - Substrate translocates into late endosomal lumen (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome lumen] (Homo sapiens)
      - HSPA8 bound autophagic substrates [late endosome lumen] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [late endosome lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [late endosome lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [late endosome lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [late endosome lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [late endosome lumen] (Homo sapiens)
        
        PolyUb-Misfolded ARL13B [late endosome lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q3SXY8 ARL13B

Gene Names

ARL13B, ARL2L1

Chain

chain:1-428

Reference Genes

BioGPS Gene:200894 ARL13B

COSMIC (genes):ARL13B ARL13B

CTD Gene:200894 ARL13B

dbSNP Gene:200894 ARL13B

ENSEMBL:ENSG00000169379 ARL13B

ENSEMBL_homo_sapiens_GENE:ENSG00000169379.17 ARL13B

HGNC:25419 ARL13B

KEGG Gene (Homo sapiens):200894 ARL13B

Monarch:200894 ARL13B

NCBI Gene:200894 ARL13B

OMIM:608922 ARL13B

UCSC:Q3SXY8 ARL13B

Reference Transcript

Other Identifiers

11727774_a_at

11745327_a_at

11748459_a_at

16942991

200894

228201_PM_at

228201_at

2632454

2632455

2632456

2632459

2632462

2632467

2632468

2632469

2632470

2632471

2632476

2632478

2632480

2632481

2632482

2632483

2632484

2632488

48263_at

79922_at

8081115

A_14_P200100

A_23_P10081

A_24_P328668

A_24_P465576

GE555014

GE88314

GO:0000166

GO:0001947

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0005930

GO:0007224

GO:0007368

GO:0009953

GO:0016020

GO:0016787

GO:0021532

GO:0021830

GO:0021943

GO:0023052

GO:0030154

GO:0031514

GO:0042995

GO:0043226

GO:0044782

GO:0048856

GO:0048870

GO:0060170

GO:0060271

GO:0070986

GO:0097500

GO:0097730

GO:1905515

HMNXSV003028902

Hs.85992.0.A1_3p_at

ILMN_2403047

PH_hs_0024119

TC03000474.hg

TC03002422.hg

Participates

as a member of

PolyUb-Misfolded cilia proteins [late endosome lumen] (Homo sapiens)

Other forms of this molecule

PolyUb-Misfolded ARL13B [lysosomal lumen]

PolyUb-Misfolded ARL13B [cytosol]

Ub-Misfolded ARL13B [cytosol]

Misfolded ARL13B [cytosol]

Misfolded ARL13B [cilium]

ARL13B [cilium]

ARL13B [plasma membrane]

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001167621.1, NP_659433.2, NP_001167622.1, NP_878899.1, XP_016861342.1

OpenTargets

ENSG00000169379

HPA

ENSG00000169379-ARL13B

GeneCards

Q3SXY8

Ensembl

ENST00000535334, ENST00000471138, ENST00000394222, ENST00000303097, ENSG00000169379, ENSP00000445145, ENSP00000377769, ENSP00000420780, ENSP00000306225

PRO

Q3SXY8

Pharos - Targets

Q3SXY8

Orphanet

18076

Interactors (136)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63252 KCNJ2	1	KCNJ2 [plasma membrane] (R-HSA-975378)	0.659	4
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.556	3
UniProt:Q8WWT9 SLC13A3	1	SLC13A3 [plasma membrane] (R-HSA-433095)	0.556	3
UniProt:A5D903 A5D903			0.556	3
UniProt:Q9Y6I9 TEX264	2	TEX264 [extracellular region] (R-HSA-8863002) TEX264 [platelet alpha granule lumen] (R-HSA-8863000)	0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:Q96MV8 ZDH15			0.556	3
UniProt:Q8WVX3-2 C4ORF3			0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:A2RU14 TM218			0.556	3
UniProt:Q8N138 ORMDL3	4	ORMDL3 [specific granule membrane] (R-HSA-6799643) ORMDL3 [plasma membrane] (R-HSA-6806293) ORMDL3 [secretory granule membrane] (R-HSA-6800882) ORMDL3 [endoplasmic reticulum membrane] (R-HSA-8865589)	0.556	3
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
IntAct:EBI-23624354 CCSB ORF ID			0.556	3
UniProt:Q9H2S6-2 TNMD			0.556	3
UniProt:P29034 S10A2			0.556	3
UniProt:Q0VAQ4 SMAGP			0.556	3
UniProt:Q6UXB4 CLEC4G	1	CLEC4G [plasma membrane] (R-HSA-1472852)	0.556	3
UniProt:O95214 LERL1			0.556	3
UniProt:Q9NTN9-2 SEMA4G			0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q96MX0 CKLF3			0.556	3
UniProt:O14569 C56D2			0.556	3
UniProt:Q8IX05 CD302			0.556	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:Q9NVV5-2 AIG1			0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:Q59EV6 Q59EV6			0.556	3
UniProt:Q8IXM6 NRM			0.556	3
UniProt:Q8NHW4 CCL4L1	1	CCL4L1 [extracellular region] (R-HSA-8865389)	0.556	3
UniProt:O15400 STX7			0.556	3
UniProt:O14798 TNFRSF10C	1	TNFRSF10C [plasma membrane] (R-HSA-5628831)	0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.556	3
UniProt:P78383 S35B1			0.556	3
UniProt:P16150 SPN	1	SPN [plasma membrane] (R-HSA-204438)	0.556	3
UniProt:Q5BJF2 SGMR2			0.556	3
UniProt:P78382 SLC35A1	2	SLC35A1 [Golgi membrane] (R-HSA-727812) SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957)	0.556	3
UniProt:P09466 PAEP			0.556	3
UniProt:Q96PS8 AQP10	1	AQP10 [plasma membrane] (R-HSA-431709)	0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:Q5VZY2 PLPP4	1	PPAPDC1A [plasma membrane] (R-HSA-2029082)	0.556	3
UniProt:P02786 TFRC	5	TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:Q71RG4 TMUB2			0.556	3
UniProt:Q9BSE2 TMM79			0.556	3
UniProt:Q8NBD8 T229B			0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:Q15546 PAQRB			0.556	3
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
IntAct:EBI-22331701 CCSB ORF ID			0.556	3
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.556	3
UniProt:P23763-3 VAMP1			0.556	3
UniProt:Q9NWW5 CLN6			0.556	3
UniProt:Q6PI78 TMM65			0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3
UniProt:Q9UBY5 LPAR3	1	LPAR3 [plasma membrane] (R-HSA-419379)	0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.556	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.556	3
UniProt:Q969K7 TMM54			0.556	3
UniProt:O75355-2 ENTPD3			0.556	3
UniProt:Q5TGU0 TSPO2			0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:Q9BTD3 TM121			0.556	3
UniProt:Q8WWP7 GIMA1			0.556	3
UniProt:Q8WZ59 TM190			0.556	3
UniProt:Q9UHJ9-5 PGAP2			0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q9BXN2-6 CLEC7A			0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [Golgi membrane] (R-HSA-434346) YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199)	0.556	3
UniProt:Q6PL45-2 BRICD5			0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:Q9BTV4 TMM43			0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:O75425 MSPD3			0.556	3
UniProt:Q6UX27-3 VSTM1			0.556	3
UniProt:O14493 CLDN4	2	CLDN4 [plasma membrane] (R-HSA-419987) CLDN4 [cell junction] (R-HSA-421244)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:P56748 CLDN8	2	CLDN8 [plasma membrane] (R-HSA-419968) CLDN8 [cell junction] (R-HSA-421243)	0.556	3
UniProt:Q96DR8 MUCL1	18	Core 8 (MUCL1) [Golgi lumen] (R-HSA-1462256) Core 2S (MUCL1) [Golgi lumen] (R-HSA-6786344) Core 5 (MUCL1) [Golgi lumen] (R-HSA-1462337) Core 4 (MUCL1) [Golgi lumen] (R-HSA-1462139) Core 3 (MUCL1) [Golgi lumen] (R-HSA-1462268) GalNAc-MUCL1 [plasma membrane] (R-HSA-8858459) Core 2 (MUCL1) [Golgi lumen] (R-HSA-1462316) Core 2a (MUCL1) [Golgi lumen] (R-HSA-6784294) GalNAc-MUCL1 [Golgi lumen] (R-HSA-913643) Sialyl Tn antigen (MUCL1) [Golgi lumen] (R-HSA-1463594) T-antigen (MUCL1) [Golgi lumen] (R-HSA-1462357) Sialyl-2,3 T-antigen (MUCL1) [Golgi lumen] (R-HSA-1463467) Sialyl T-antigen (MUCL1) [Golgi lumen] (R-HSA-1463524) Disialyl T-antigen (MUCL1) [Golgi lumen] (R-HSA-1463480) MUCL1 [Golgi lumen] (R-HSA-913632) Core 6 (MUCL1) [Golgi lumen] (R-HSA-1462246) extended Core 6 (MUCL1) [Golgi lumen] (R-HSA-1967042) Core 7 (MUCL1) [Golgi lumen] (R-HSA-1462181)	0.556	3
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.556	3
UniProt:P19397 CD53	3	CD53 [specific granule membrane] (R-HSA-6804793) CD53 [plasma membrane] (R-HSA-6804817) CD53 [tertiary granule membrane] (R-HSA-6804799)	0.556	3
UniProt:Q9UHE5 NAT8	1	NAT8 [endoplasmic reticulum membrane] (R-HSA-5692986)	0.556	3
UniProt:Q16617 NKG7			0.556	3
UniProt:O14523 C2C2L			0.556	3
UniProt:Q969L2 MAL2			0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q16853 AOC3	1	AOC3 [plasma membrane] (R-HSA-5696151)	0.556	3
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.556	3
UniProt:Q9P0B6 CC167			0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:P11215 ITGAM	3	ITGAM [specific granule membrane] (R-HSA-6799647) ITGAM [tertiary granule membrane] (R-HSA-6800979) ITGAM [plasma membrane] (R-HSA-202757)	0.556	3
UniProt:Q8TBM7 TM254			0.556	3
UniProt:A6NDP7 MADL2			0.556	3
UniProt:Q9BXR6 CFHR5	1	CFHR5 [extracellular region] (R-HSA-8851419)	0.556	3
UniProt:Q9BWH2 FUND2			0.556	3
UniProt:Q9UPZ6 THSD7A	3	THSD7A [endoplasmic reticulum lumen] (R-HSA-5173009) glc-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173197) O-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173184)	0.556	3
UniProt:Q12983 BNIP3			0.556	3
UniProt:O60725 ICMT	1	ICMT [endoplasmic reticulum membrane] (R-HSA-6788651)	0.556	3
UniProt:CXCL16 A0A6I8PIU0			0.556	3
UniProt:Q4VAQ0 Q4VAQ0			0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:Q96GM1 PLPPR2	1	LPPR2 [plasma membrane] (R-HSA-6797629)	0.556	3
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.556	3
UniProt:Q9C0I4 THSD7B	3	THSD7B [endoplasmic reticulum lumen] (R-HSA-5173101) glc-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5172957) O-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5173124)	0.556	3
UniProt:Q9BZW4 TM6S2			0.556	3
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:P22732 SLC2A5	2	SLC2A5 [plasma membrane] (R-HSA-189202) SLC2A5 [specific granule membrane] (R-HSA-6799571)	0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:Q14656 TM187			0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:Q14508 WFDC2	1	WFDC2 [extracellular region] (R-HSA-9830363)	0.556	3
UniProt:Q8NHY0 B4GALNT2	1	B4GALNT2 [Golgi membrane] (R-HSA-8855939)	0.556	3
UniProt:Q92685 ALG3	5	ALG3 [endoplasmic reticulum membrane] (R-HSA-449287) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:Q8WYA0 IFT81	2	IFT81 [cilium] (R-HSA-5617769) IFT81 [ciliary tip] (R-HSA-5625369)	0.527	2
UniProt:Q86WT1 IFT70A	2	TTC30A [ciliary tip] (R-HSA-5637966) TTC30A [cilium] (R-HSA-5637968)	0.527	2
UniProt:Q96LB3 IFT74	2	IFT74 [cilium] (R-HSA-5617616) IFT74 [ciliary tip] (R-HSA-5625364)	0.527	2
UniProt:Q9Y366 IFT52	2	IFT52 [ciliary tip] (R-HSA-5625360) IFT52 [cilium] (R-HSA-5610387)	0.527	2
UniProt:Q9H7X7 IFT22	2	RABL5 [cilium] (R-HSA-5617605) RABL5 [ciliary tip] (R-HSA-5625388)	0.527	2
UniProt:Q9ULJ7 ANR50			0.527	2
UniProt:O00506 STK25			0.527	2

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