Reactome | PolyUb-Misfolded IFT88 [lysosomal lumen]

PolyUb-Misfolded IFT88 [lysosomal lumen]

Stable Identifier

R-HSA-9660026

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Chaperone Mediated Autophagy (Homo sapiens)
  - HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded IFT88 [lysosomal lumen] (Homo sapiens)
  - HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded IFT88 [lysosomal lumen] (Homo sapiens)
    - HSPA8:Substrates for CMA [lysosomal lumen] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded IFT88 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13099 IFT88

Gene Names

IFT88, TG737, TTC10

Chain

chain:1-824

Reference Genes

BioGPS Gene:8100 IFT88

COSMIC (genes):IFT88 IFT88

CTD Gene:8100 IFT88

dbSNP Gene:8100 IFT88

ENSEMBL:ENSG00000032742 IFT88

HGNC:20606 IFT88

KEGG:hsa:8100 IFT88

Monarch:8100 IFT88

NCBI Gene:8100 IFT88

OMIM:600595 IFT88

UCSC:Q13099 IFT88

Reference Transcript

Other Identifiers

11721726_a_at

11748955_a_at

11748956_x_at

16772994

204703_PM_at

204703_at

2666289

34284_at

3480415

3480416

3480417

3480419

3480421

3480422

3480423

3480424

3480426

3480427

3480428

3480429

3480430

3480431

3480432

3480433

3480434

3480435

3480454

3480456

3480457

3480458

3480459

3480460

3480461

3480462

3480463

3480464

3480465

3480466

3480467

3480468

3480469

3480471

3480477

3480478

3480479

3480480

3480486

3480498

3480501

3480502

3480503

3480504

42080_at

7967933

8100

A_14_P106901

A_14_P113568

A_14_P125798

A_23_P48339

GE58997

GO:0001822

GO:0002177

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0007018

GO:0008092

GO:0019894

GO:0030030

GO:0030992

GO:0031514

GO:0034021

GO:0035720

GO:0036064

GO:0036126

GO:0042073

GO:0043226

GO:0044782

GO:0045724

GO:0048856

GO:0060122

GO:0060271

GO:0097542

GO:0097546

GO:0097730

GO:0120212

GO:1902017

GO:1905515

GO:2000785

HMNXSV003034453

HMNXSV003037033

ILMN_1666560

ILMN_1669366

ILMN_2373755

PH_hs_0023237

TC13000025.hg

U20362_at

g5729799_3p_at

Participates

as a member of

PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

PolyUb-Misfolded IFT88 [cytosol]

Ub-Misfolded IFT88 [cytosol]

Misfolded IFT88 [cytosol]

Misfolded IFT88 [cilium]

IFT88 [cilium]

PolyUb-Misfolded IFT88 [late endosome lumen]

IFT88 [ciliary tip]

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_006522.2, XP_006719933.1, XP_016876246.1, XP_011533543.1, XP_011533544.1, XP_011533545.1, XP_016876247.1, NP_001305420.1, NP_783195.2, XP_005266610.1

OpenTargets

ENSG00000032742

ENSEMBL

ENSP00000261632, ENSP00000323580, ENST00000351808, ENST00000319980

HPA

ENSG00000032742-IFT88

PRO

Q13099

Pharos - Targets

Q13099

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.724	8
UniProt:Q9BW83 IFT27	2	IFT27 [ciliary tip] (R-HSA-5625357) IFT27 [cilium] (R-HSA-5617621)	0.724	9
UniProt:Q9H7X7 IFT22	2	RABL5 [cilium] (R-HSA-5617605) RABL5 [ciliary tip] (R-HSA-5625388)	0.724	8
UniProt:Q9NQC8 IFT46	2	IFT46 [ciliary tip] (R-HSA-5625359) IFT46 [cilium] (R-HSA-5617617)	0.724	8
UniProt:Q86WT1 IFT70A	2	TTC30A [ciliary tip] (R-HSA-5637966) TTC30A [cilium] (R-HSA-5637968)	0.724	9
UniProt:Q8N4P2 IFT70B	2	TTC30B [ciliary tip] (R-HSA-5637970) TTC30B [cilium] (R-HSA-5637971)	0.724	8
UniProt:Q9Y547 HSPB11	2	HSPB11 [ciliary tip] (R-HSA-5625342) HSPB11 [cilium] (R-HSA-5617628)	0.724	6
UniProt:Q9UG01 IFT172	2	IFT172 [ciliary tip] (R-HSA-5625353) IFT172 [cilium] (R-HSA-5610383)	0.643	9
UniProt:Q8IY31 IFT20	3	IFT20 [ciliary tip] (R-HSA-5625355) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624)	0.643	6
UniProt:Q96LB3 IFT74	2	IFT74 [ciliary tip] (R-HSA-5625364) IFT74 [cilium] (R-HSA-5617616)	0.643	7
UniProt:A0AVF1 TTC26	2	TTC26 [ciliary tip] (R-HSA-5637962) TTC26 [cilium] (R-HSA-5637963)	0.643	6
UniProt:Q9P2H3 IFT80	2	IFT80 [ciliary tip] (R-HSA-5625367) IFT80 [cilium] (R-HSA-5617613)	0.643	8
UniProt:Q8WYA0 IFT81	2	IFT81 [cilium] (R-HSA-5617769) IFT81 [ciliary tip] (R-HSA-5625369)	0.643	6
UniProt:Q9Y366 IFT52	2	IFT52 [ciliary tip] (R-HSA-5625360) IFT52 [cilium] (R-HSA-5610387)	0.643	6
UniProt:Q96AJ1 CLUAP1	2	CLUAP [ciliary tip] (R-HSA-5637957) CLUAP [cilium] (R-HSA-5637960)	0.592	4
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.592	4
UniProt:Q96G04 EEF2KMT	1	EEF2KMT [cytosol] (R-HSA-8876690)	0.556	3
UniProt:P27987 ITPKB	1	ITPKB [cytosol] (R-HSA-1604605)	0.556	3
UniProt:Q9NZV6 MSRB1	1	MSRB1 [cytosol] (R-HSA-5676936)	0.556	3
UniProt:A0A0C4DGQ7 A0A0C4DGQ7			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.556	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	3
UniProt:O60303 KATIP			0.482	2
UniProt:Q13099 IFT88	8	PolyUb-Misfolded IFT88 [lysosomal lumen] (R-HSA-9660026) PolyUb-Misfolded IFT88 [cytosol] (R-HSA-9641125) Ub-Misfolded IFT88 [cytosol] (R-HSA-9641114) Misfolded IFT88 [cytosol] (R-HSA-9640115) Misfolded IFT88 [cilium] (R-HSA-9640106) IFT88 [cilium] (R-HSA-5610385) PolyUb-Misfolded IFT88 [late endosome lumen] (R-HSA-9660031) IFT88 [ciliary tip] (R-HSA-5625371)	0.462	4