Reactome | RAS:GTP binds RAL GDS proteins

RAS:GTP binds RAL GDS proteins

Stable Identifier

R-HSA-9660557

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RAL GDS and related family members RGL1, 2 and 3 are small GTPase proteins in the RAS family that act as effectors downstream of HRAS and other RAS proteins (reviewed in Ferro and Trabalzini, 2010; Gentry et al, 2014). RALGDS family members bind to HRAS in the GTP-bound state through the RALGDS Ras binding domains (RBDs) and acts as RAL A and RAL B-specific guanine nuclear exchange factors (GEFs) (Hofer et al, 1994; Spaargen et al, 1994; Kikuchi et al, 1994; Wolthius et al, 1996; Peterson et al, 1996; Shao et al, 2000; Ehrhardt et al, 2001; reviewed in Gentry et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
10869344	A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras Andres, DA, Shao, H	J. Biol. Chem.	2000
25219551	Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame Der, CJ, Martin, TD, Gentry, LR, Reiner, DJ	Biochim. Biophys. Acta	2014
20478380	RalGDS family members couple Ras to Ral signalling and that's not all Ferro, E, Trabalzini, L	Cell. Signal.	2010
7809086	Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap Spaargaren, M, Bischoff, JR	Proc. Natl. Acad. Sci. U.S.A.	1994
8710374	RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein Burgering, BM, Spaargaren, M, De Vries-Smits, AM, Wolthuis, RM, Bauer, B, Bos, JL, van 't Veer, LJ, Wittinghofer, A, Cool, RH	Oncogene	1996
8939933	Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1 Altschuler, DL, Martelli, P, White, GC, Lapetina, EG, Trabalzini, L, Peterson, SN, Der, CJ, Fischer, T, Brtva, TR	J. Biol. Chem.	1996
7972015	Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator Hofer, F, Schneider, C, Fields, S, Martin, GS	Proc Natl Acad Sci U S A	1994
11313946	A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth Knaus, M, Ehrhardt, GR, Wieler, JS, Schrader, JW, Korherr, C	Oncogene	2001
7935463	ralGDS family members interact with the effector loop of ras p21 Kikuchi, A, Ye, ZH, Demo, SD, Williams, LT, Chen, YW	Mol. Cell. Biol.	1994