ADORA2B:Ade-Rib binds heterometric G-protein Gs

Stable Identifier
R-HSA-9660828
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ADORA2B:Ade-Rib binds heterometric G-protein Gs
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The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.
Literature References
PubMed ID Title Journal Year
12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus

Feldman, DS, Luttrell, LM, Pierce, KL, Kelly, F, Koch, WJ, Rapacciuolo, A, Miller, WE, Zamah, AM, Rockman, HA

J Biol Chem 2002
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Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-09-12)
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