Defective translocation of RB1 mutants to the nucleus

Stable Identifier
R-HSA-9661070
Type
Pathway
Species
Homo sapiens
Compartment
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This pathway describes impaired nuclear localization of RB1 mutants that lack the nuclear localization signal (NLS) (Zacksenhaus et al. 1993, Bremner et al. 1997).

Literature References
PubMed ID Title Journal Year
9326321 Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma

Bremner, R, Du, DC, Connolly-Wilson, MJ, Bridge, P, Ahmad, KF, Mostachfi, H, Rushlow, D, Dunn, JM, Gallie, BL

Am. J. Hum. Genet. 1997
8336704 A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity

Zacksenhaus, E, Bremner, R, Phillips, RA, Gallie, BL

Mol. Cell. Biol. 1993
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
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