SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Stable Identifier
R-HSA-9661723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The solute carrier organic anion transporter family member 2B1 (SLCO2B1, aka OATPRP2, OATPB, SLC21A9), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (Kullak-Ublick et al. 2001). The predominant isoform in the liver is SLCO2B1 isoform 3 (Knauer et al. 2013).

Literature References
PubMed ID Title Journal Year
23531488 Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant

Knauer, MJ, Girdwood, AJ, Kim, RB, Tirona, RG

Mol. Pharmacol. 2013
11159893 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B

Gastroenterology 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
sodium-independent organic anion transmembrane transporter activity of SLCO2B1-3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created